Intrinsic Temperature Dependence of Raman-Active Modes in Individual Isolated Single- and Double-Walled Carbon Nanotubes.

The intrinsic temperature dependence of Raman-active modes in carbon nanotubes (CNTs), particularly the radial breathing mode (RBM), has been a topic of a long-standing controversy. In this study, we prepared suspended individual CNTs to investigate how their Raman spectra depend on temperature and to understand the effects of environmental conditions on this dependency. We analyzed the intrinsic temperature dependence of the main Raman-active modes, including the RBM, the moiré-activated R feature, and the G-band in double-walled carbon nanotubes (DWCNT) and single-walled carbon nanotubes (SWCNTs) after complete desorption of air.

An HRP-integrated CRISPR/Cas12a biosensor towards chair-side diagnosis for Porphyromonas gingivalis.

Rapid diagnostic tools for Porphyromonas gingivalis (Pg), the primary microorganism responsible for the development of periodontitis, particularly those designed for chair-side applications, could provide substantial health benefits to patients. To address this issue, we developed a CRISPR/Cas12a-based rapid Pg detection method. Dual-gRNA and hairpin reporter strategies were employed to enhance CRISPR/Cas12a reaction efficiency.

CircRNA-mediated heterogeneous ceRNA regulation mechanism in periodontitis and peri-implantitis.

Background: Performing a comprehensive study on the differential expression of mRNAs, miRNAs, and circRNAs in the context of peri-implantitis and periodontitis has beneficial advantages to identify unique molecular signatures and pathways that may contribute to our understanding of these conditions.

Methods: Gingival tissues from healthy individuals and peri-implantitis and periodontitis patients were obtained to identify differential expression genes (DEG) by Illumina HiSeq 2500 instrument. Differential expression analysis was conducted using R statistical software, with significance set at P < 0.

Lighting quality evaluation on growth performance and feather pecking behavior of broilers.

Light is an important factor affecting the feather pecking behavior in poultry. To evaluate the quality of lighting in production of a local broiler breed, this study was designed to investigate the effects of light color on the growth performance (body weight, feed conversion ratio and upper beak length), welfare parameters (walking step, plumage damage and hormone level) relating to feather pecking and their correlations. One hundred and twenty 49-day-old Youhuang broilers were randomly distributed into 3 lighting treatment groups (warm white, cold white and red) and reared for 4 weeks.

Physical activity and risk of depression in adolescents: A systematic review and meta-analysis of prospective observational studies.

Background: While the benefits of physical activity (PA) on depression in adults have been well-established, its impact on depression in adolescents remains understudied. This study aimed to examine the relationship between PA and depression in adolescents, aggregating published prospective observational studies.

Methods: We searched MEDLINE, Embase, Cochrane, and PsycINFO, for prospective observational studies that examined the relationship between PA and depression in adolescents from the inception of these databases to November 17, 2022, without any language restrictions.

Development and validation of a nomogram for predicting early acute hydrocephalus after spontaneous intracerebral hemorrhage: a single-center retrospective study.

Acute hydrocephalus is a severe complication that may occur early after an intracerebral hemorrhage (ICH). However, clinical factors predicting the occurrence of acute hydrocephalus have rarely been studied. This study aimed to establish a nomogram model to predict early acute hydrocephalus after ICH.

Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression.

It has been established that N-acetyltransferase (murine NAT1 (mNAT1) and human NAT2 (hNAT2)) mediates insulin sensitivity in type 2 diabetes. Here we show that mNAT1 deficiency leads to a decrease in cellular spermidine-a natural polyamine exhibiting health-protective and anti-ageing effects-but understanding of its mechanism is limited. We identify that mNAT1 and hNAT2 modulate a type of post-translational modification involving acetylated spermidine, which we name acetylhypusination, on receptor-interacting serine/threonine-protein kinase 1 (RIPK1)-a key regulator of inflammation and cell death.

Glycerol-derived reuterin regulates human intestinal microbiota and metabolites.

Reuterin, a mixture of different forms of 3-hydroxypropanal (3-HPA), including HPA hydrate and HPA dimer, is an antimicrobial compound converted from glycerol by . Although its antimicrobial function may be related to its interaction with thiol groups, its temperature stability and effect on the gut environment remain unclear. The present study evaluated the antimicrobial effects and activity of reuterin against and .

Molecular Dynamics of Catalyst-Free Edge Elongation of Boron Nitride Nanotubes Coaxially Grown on Single-Walled Carbon Nanotubes.

Recent advances in low-dimensional materials have enabled the synthesis of single-walled carbon nanotubes encapsulated in hexagonal boron nitride (BN) nanotubes (SWCNT@BNNT), creating one-dimensional van der Waals (vdW) heterostructures. However, controlling the quality and crystallinity of BNNT on the surface of SWCNTs using chemical vapor deposition (CVD) remains a challenge. To better understand the growth mechanism of the BNNT in SWCNT@BNNT, we conducted molecular dynamics (MD) simulations using empirical potentials.

Efficient Growth of 1D Van der Waals Heterostructures on Zeolite-Supported SWCNTs.

The controlled synthesis of 1D van der Waals (1D vdW) heterostructures, specifically single-walled carbon nanotubes encapsulated within boron nitride nanotubes (SWCNT@BNNT), presents a challenge due to an incomplete understanding of the factors influencing BNNT growth. This study investigates the growth yield of SWCNT@BNNT heterostructures produced using zeolite-supported SWCNT templates on SiO-coated Transmission Electron Microscopy (TEM) grids, which enable in situ synthesis and thorough evaluation of each step without compromising the nanotube structure. The high-resolution TEM analysis reveals a significant improvement in BNNT coverage on individual nanotubes, increasing from 9% to 42%, through optimization of the ammonia borane precursor amount.

Shared Genetic Architecture and Causal Relationship between Serum 25-Hydroxyvitamin D and Bone Mineral Density.

Background: Despite the well-established regulatory role of vitamin D in maintaining bone health, little is known about the shared genetics and causality of the association between serum 25-hydroxyvitamin D (25OHD) and bone mineral density (BMD).

Methods: Leveraging individual-level data from the UK Biobank (UKB) cohort and summary-level data from the genome-wide association studies (GWASs) conducted on European individuals for serum 25OHD (N = 417,580) and estimated heel BMD (eBMD, N = 426,824), we systematically elucidated the shared genetic architecture underlying serum 25OHD and eBMD through a comprehensive genome-wide cross-trait design.

Results: Despite a lack of global genetic correlation (rg = -0.

Single-cell atlas profiling revealed cellular characteristics and dynamic changes after PD-1 blockade therapy of brain metastases from laryngeal squamous cell carcinoma.

Brain metastasis (BM) in laryngeal squamous cell carcinoma (LSCC) is uncommon but prognosis is poor. Anti-PD-1 immunotherapy benefits some advanced LSCC cases, yet its efficiency is limited by tumor complexity. We analyzed paired metastatic tumor samples from before and after immunotherapy using single-cell RNA sequencing (scRNA-seq), along with a primary LSCC dataset and bulk RNA sequencing.

Identification of truncated variants in GLI family zinc finger 3 (GLI3) associated with polydactyly.

Background: Polydactyly is a prevalent congenital anomaly with an incidence of 2.14 per 1000 live births in China. GLI family zinc finger 3 (GLI3) is a classical causative gene of polydactyly, and serves as a pivotal transcription factor in the hedgehog signaling pathway, regulating the development of the anterior-posterior axis in limbs.

Single-cell transcriptomic profiling reveals decreased ER protein Reticulon3 drives the progression of renal fibrosis.

Chronic kidney disease (CKD) poses a significant global health dilemma, emerging from complex causes. Although our prior research has indicated that a deficiency in Reticulon-3 (RTN3) accelerates renal disease progression, a thorough examination of RTN3 on kidney function and pathology remains underexplored. To address this critical need, we generated Rtn3-null mice to study the consequences of RTN3 protein deficiency on CKD.

Double domain fusion improves the reverse transcriptase activity and inhibitor tolerance of Bst DNA polymerase.

To enhance the DNA/RNA amplification efficiency and inhibitor tolerance of Bst DNA polymerase, four chimeric Bst DNA polymerase by fusing with a DNA-binding protein Sto7d and/or a highly hydrophobic protein Hp47 to Bst DNA polymerase large fragment. One of chimeric protein HpStBL exhibited highest inhibitor tolerance, which retained high active under 0.1 U/μL sodium heparin, 0.

Superoxide is an Intrinsic Signaling Molecule Triggering Muscle Hypertrophy.

Redox signaling plays a key role in skeletal muscle remodeling induced by exercise and prolonged inactivity, but it is unclear which oxidant triggers myofiber hypertrophy due to the lack of strategies to precisely regulate individual oxidants . In this study, we used tetrathiomolybdate (TM) to dissociate the link between superoxide (O) and hydrogen peroxide and thereby to specifically explore the role of O in muscle hypertrophy in C2C12 cells and mice. TM can linearly regulate intracellular O levels by inhibition of superoxide dismutase 1 (SOD1).

[Research progress of genetic research on Char syndrome].

Char syndrome is a rare autosomal dominant genetic disorder characterized by patent ductus arteriosus, facial dysmorphism, and dysplasia of fingers/toes. It may also be associated with multiple papillae, dental dysplasia, and sleep disorders. TFAP2B has proven to be a pathogenic gene for neural crest derivation and development, and several variants of this gene have been identified.

Targeting tumor cell-to-macrophage communication by blocking Vtn-C1qbp interaction inhibits tumor progression via enhancing macrophage phagocytosis.

Cancer cells are capable of evading clearance by macrophages through overexpression of anti-phagocytic surface proteins known as "don't eat me" signals. Monoclonal antibodies that antagonize the "don't-eat-me" signaling in macrophages and tumor cells by targeting phagocytic checkpoints have shown therapeutic promises in several cancer types. However, studies on the responses to these drugs have revealed the existence of other unknown "don't eat me" signals.

Multifactor and multidimensional data quality analysis of judge scoring in diving competition.

Introduction: In sports competitions, judge scoring data serve as an objective measure of an athlete's performance level. However, research has indicated the unreliability of objective measurements. Controversy often arises regarding the quality of judge scoring data, undermining fairness and justice in sports competitions.