A-D-A Molecular Design Strategy Enabling Ultrasensitive NIR Vapor Sensing.

Thin-film fluorescent chemosensors, characterized by their tunable design, high selectivity, and exceptional sensitivity, hold significant promise for gas detection applications. However, the simultaneous realization of the 3S attributes (sensitivity, selectivity, and stability) remains a formidable challenge, particularly in the underexplored field of near-infrared (NIR) gas detection. In this work, we employ an acceptor-donor-acceptor (A-D-A) molecular design strategy to drive the development of an organic semiconductor fluorescent material with a progressive red shift in the emission wavelength.

Evaluation of low nitrogen resistance of germplasm during the seed germination period.

Nitrogen (N) plays a crucial role in forage yield. However, excessive application of N fertilizers in agricultural production not only increases the production cost but also leads to serious environmental problems. Therefore, mining low-N tolerant oat germplasm is important for the sustainable development of grass and pasture.

Thermal Modulation of Exciton Recombination for High-Temperature Ultra-Long Afterglow.

Developing smart materials with tunable high-temperature afterglow (HTA) luminescence remains a formidable challenge. This study presents a metal-free doping system using boric acid as matrix and polycyclic aromatic hydrocarbons as dopants. This composition achieves dynamically tunable afterglow combining a bright blue HTA lasting for over ten seconds even at 150°C and an ultra-long yellow room-temperature phosphorescence below 110°C.

Synthesis and Preclinical Evaluation of Dual-Specific Probe Targeting Glypican-3 and Prostate-Specific Membrane Antigen for Hepatocellular Carcinoma PET Imaging.

Positron emission tomography (PET) is a promising modality for early diagnosis, accurate detection, and staging of hepatocellular carcinoma (HCC). Hereby, a dual-specific probe targeting Glypican-3 (GPC3) and prostate-specific membrane antigen (PSMA) was evaluated for HCC PET imaging. The probe was prepared by conjugating TJ12P2, a GPC3-targeting peptide previously reported by our group, to a highly potent PSMA inhibitor via a polyethylene glycol linker and further tethered to the 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) chelator.

Fast-speed and low-power-consumption optical phased array based on lithium niobate waveguides.

Fast scanning speed and low-power consumption are becoming progressively more and more important in realizing high-performance chiplet optical phased arrays (OPAs). Here, we successfully demonstrated integrated OPAs with multiple waveguides channels based on thin-film lithium niobate-on-insulator (LNOI) platform. Specifically, two lithium niobate (LN) OPA chips have been implemented with 32 and 48 channels LN waveguides, respectively, enabled by electro-optic modulations, which showcases the low power consumption (1.

Adaptive wireless-powered network based on CNN near-field positioning by a dual-band metasurface.

With the improvement of industry, the connectivity of electronic devices gradually shift from wired to wireless. As a solution for power delivery, the non-contact power transfer holds promising ways to charge for moving terminals, enabling battery-free sensing, processing, and communication. Based on a dual-band metasurface, this study proposes an adaptive wireless-powered network (AWPN) to realize the simultaneous wireless localization and non-contact power supply.

Whole Genome Sequencing and Biocontrol Potential of ASG80 Against Diseases.

-induced crop diseases, commonly known as "plant plagues", pose a significant threat to global food security. In this study, strain ASG80 was isolated from sisal roots and demonstrated a broad-spectrum antagonistic activity against several species and fungal pathogens. Strain ASG80 was identified as via phylogenetic analysis, digital DNA-DNA hybridization (dDDH), and average nucleotide identity (ANI).

Inhibition of hepatic PCSK9 as a novel therapeutic target ameliorates metabolic steatohepatitis in mice.

Background & Aims: Metabolic steatohepatitis (MASH) is closely related to metabolic disorders, and the main characteristics of MASH are hepatocyte steatosis with hepatocyte injury and inflammation. In severe cases, MASH can develop into liver cirrhosis. At present, there is no effective treatment for MASH.

Discovery of potent hypoxia-inducible factor-1α (HIF-1α) degraders by proteolysis targeting chimera (PROTAC).

Under hypoxic conditions in tumor cells, HIF-1α is unable to bind to VHL E3 ligase due to the blocked hydroxylation reaction, resulting in impaired degradation and intracellular accumulation. Mounting evidences show a close association between HIF-1α overexpression and drug resistance, treatment failure, and increased mortality. To address HIF-1α overexpression, we innovatively introduced an E3 ligase ligand to the HIF-1α inhibitor IDF-11774 using the PROTACs strategy, aiming to reactivate the degradative pathway impeded under hypoxia, and thereby achieve the degradation of HIF-1α protein under hypoxia.

Becoming Eligible for Long-Term Care Insurance in China Brought More Ageing at Home: Evidence from a Pilot City.

Person-centered long-term care systems, integral to healthy ageing, should empower older people to achieve ageing in place. Yet evidence on the impact of the design of long-term care systems on older people's choice of places of ageing, especially that from developing countries, is limited. Taking the introduction of Long-Term Care Insurance (LTCI) in City X of China as a policy shock, we examined the impact of becoming eligible for LTCI on program beneficiaries' choice of places of ageing-institution or home-before they started to receive any actual benefit.

A d-Cd Cluster Containing Sandwich-Type Arsenotungstate Exhibiting Fluorescent Recognition of Carcinogenic Dye in Methanol.

A d-Cd cluster containing sandwich-type arsenotungstate [CHN][CdCl(B--AsWO)] was synthesized and its structure characterized through elemental analyses, X-ray powder diffraction (XRPD), IR spectroscopy, X-ray photoelectron spectroscopy (XPS), and single-crystal X-ray diffraction. The X-ray analysis revealed that the molecular unit of the compound consists of a captivating tetra-Cd-substituted sandwich-type polyoxoanion, accompanied by six elegantly protonated 1,2-diaminopropane as counter ions. The further novelty of the tetranuclear cadmium cluster lies in its occupied chlorine atom sites.

Disrupting endogenous retroelements with a reverse transcriptase inhibitor alleviates DSS-induced colitis in mice.

Endogenous retroelements play vital roles in sustaining immune homeostasis. Activation of endogenous retroelements can trigger cGAS/STING pathway and downstream pro-inflammatory cytokine production. M1 macrophages, which can be induced by pro-inflammatory cytokines, are involved in the development of colitis.

Functional investigation and two-sample Mendelian randomization study of primary biliary cholangitis hub genes.

Background: The identification of specific gene expression patterns is crucial for understanding the mechanisms underlying primary biliary cholangitis (PBC) and finding relevant biomarkers for diagnosis and therapeutic evaluation.

Aim: To determine PBC-associated hub genes and assess their clinical utility for disease prediction.

Methods: PBC expression data were obtained from the Gene Expression Omnibus database.

Near-Infrared Room-Temperature Phosphorescence from Monocyclic Luminophores.

Compact luminophores with long emission wavelengths have aroused considerable theoretical and practical interest. Organics with room-temperature phosphorescence (RTP) are also desirable for their longer lifetimes and larger Stokes shifts than fluorescence. Utilizing the low electronic transition energy intrinsic to thiocarbonyl compounds, electron-withdrawing groups were attached to the 4H-pyran-4-thione core to further lower the excited state energies.

Novel Insights Into DLAT's Role in Alzheimer's Disease-Related Copper Toxicity Through Microglial Exosome Dynamics.

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder, with recent research emphasizing the roles of microglia and their secreted extracellular vesicles in AD pathology. However, the involvement of specific molecular pathways contributing to neuronal death in the context of copper toxicity remains largely unexplored.

Objective: This study investigates the interaction between pyruvate kinase M2 (PKM2) and dihydrolipoamide S-acetyltransferase (DLAT), particularly focusing on copper-induced neuronal death in Alzheimer's disease.

A data-driven guaranteed zonotopic estimation for unknown time-varying system.

Time-varying system is a widespread class of systems in reality. Model of such system is difficult to obtain because the parameters vary with time. Hence, a data-driven state estimation for unknown discrete time-varying system is investigated with zonotopic reachability analysis.

Short-Term Prognostic Risk Factors and Nomogram Predictive Model Construction for Acute Ischaemic Stroke after Endovascular Treatment.

Objective: To investigate the factors influencing the severity of acute ischaemic stroke (AIS) and short-term prognosis after endovascular treatment.

Study Design: Observational study. Place and Duration of the Study: Department of Cerebrovascular Diseases, The First People's Hospital of Qujing City, Yunnan Province, China, from June 2020 to December 2022.

Dual-Path Large Kernel Learning and Its Applications in Single-Image Super-Resolution.

To enhance the performance of super-resolution models, neural networks frequently employ module stacking. However, this approach inevitably results in an excessive proliferation of parameter counts and information redundancy, ultimately constraining the deployment of these models on mobile devices. To surmount this limitation, this study introduces the application of Dual-path Large Kernel Learning (DLKL) to the task of image super-resolution.