Efficacy and safety of tirofiban in acute ischemic stroke patients with ideal reperfusion: A cohort study of LAA and CE subgroups.

Background And Objectives: Despite achieving ideal reperfusion (eTICI = 3) through endovascular treatment (EVT), some acute ischemic stroke (AIS) patients still experience poor outcomes. This study aims to evaluate the efficacy and safety of tirofiban in AIS patients with ideal reperfusion, focusing on its effects in large artery atherosclerosis (LAA) and cardioembolic (CE) stroke.

Methods: A total of 474 AIS patients from the RESCUE-BT database were included.

Genome-Wide Structural Variation Analysis and Breed Comparison of Local Domestic Ducks in Shandong Province, China.

Structural variations in the duck genome significantly impact the environmental adaptability and phenotypic diversity of duck populations. Characterizing these SVs in local domestic duck breeds from Shandong province offers valuable insights for breed selection and the development of new breeds. This study aimed to profile the genomic SVs in three local duck breeds (Matahu duck, Weishan partridge duck, and Wendeng black duck) and explore their differential distributions.

Association between weight-adjusted-waist index and serum anti-aging protein α-Klotho in U.S. adults: Evidence from NHANES 2007-2016.

Background: As unhealthy diets have proliferated, there has been an increasing trend in the prevalence of obesity along with socioeconomic progress. WWI, mainly representing weight-independent central obesity, is a more accurate indicator of obesity than BMI and WC. Klotho is known to be one of the root causes of several age-related illnesses.

Sarcopenia as a Prognostic Factor and Multimodal Interventions in Breast Cancer.

Objective: This study aims to demonstrate the impact of sarcopenia on the prognosis of early breast cancer and its role in early multimodal intervention.

Methods: The clinical data of patients (n=285) subjected to chemotherapy for early-stage breast cancer diagnosed pathologically between January 1, 2016, and December 31, 2020, in our hospital were retrospectively analyzed. Accordingly, the recruited subjects were divided into sarcopenia (n=85) and non-sarcopenia (n=200) groups according to CT diagnosis correlating with single-factor and multifactorial logistic regression analyses.

Identification of genetic loci and candidate genes regulating photosynthesis and leaf morphology through genome-wide association study in L.

Rapeseed ( L.) is a major agricultural crop with diverse applications, particularly in the production of seed oil for both culinary use and biodiesel. However, its photosynthetic efficiency, a pivotal determinant of yield, remains relatively low compared with other C plants such as rice and soybean, highlighting the necessity of identifying the genetic loci and genes regulating photosynthesis in rapeseed.

Artificial intelligence in precision medicine for lung cancer: A bibliometric analysis.

Background: The increasing body of evidence has been stimulating the application of artificial intelligence (AI) in precision medicine research for lung cancer. This trend necessitates a comprehensive overview of the growing number of publications to facilitate researchers' understanding of this field.

Method: The bibliometric data for the current analysis was extracted from the Web of Science Core Collection database, CiteSpace, VOSviewer ,and an online website were applied to the analysis.

Sang-Bai-Pi extract and its constituent regiafuran C ameliorate renal fibrosis through TGF-β/Smad and Wnt/β-catenin signaling pathways.

Background: Renal fibrosis is a major pathological feature of many chronic kidney diseases, and traditional Chinese medicines (TCM) have shown promising therapeutic potential for treating renal fibrosis. Although the extracts or fractions of Morus alba leaves and twigs have been reported to ameliorate renal fibrosis, the beneficial effects of M. alba root bark (commonly known as Sang-Bai-Pi), a well-known TCM, on this disorder have not been investigated.

Fluorescent "on-off-on" sensor based on N, P co-doped carbon nanoparticles for specific detection of Fe and ascorbic acid.

Ascorbic acid (AA) is used as a food additive for its antibacterial and antioxidant properties. However, excessive intake of AA is harmful to humans. Therefore, the detection of Fe and AA is generally recognized to be meaningful.

Viral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization.

The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNALP) is essential for the immortalization of naive B lymphocytes (NBLs). However, the mechanisms remain elusive. To understand EBNALP's role in B-cell transformation, we compare NBLs infected with wild-type EBV and an EBNALP-null mutant EBV using multi-omics techniques.

Amino-functionalized HPU-23@Ru@Tb as light-driven oxidase-like nanozyme for colorimetric recognition of Hg and ratiometric fluorescence sensing of ClO and PO.

A HPU-23@Ru@Tb-NH sensor array with light-driven oxidase-mimicking activity and triple-emission fluorescence was developed. It was composed of a Tb-functionalized metal organic framework and Ru(bpy) and applied to the simultaneous detection of Hg, ClO, and PO via differently responsive channels. HPU-23@Ru@Tb-NH had a photoresponsive colorimetric response toward Hg with a LOD as low as 4.

Determining the effective dose of esketamine combined with propofol for painless hysteroscopy: a prospective dose-finding study.

Background: The combination of esketamine and propofol has become a common choice for total intravenous anesthesia in hysteroscopic procedures. However, the optimal effective dose has not yet been determined. The aim of this study was to determine the median effective dose (ED) and 95% effective dose (ED) of esketamine compounded with propofol for painless hysteroscopy.

Exploring the molecular mechanisms of comorbidity of myocardial infarction and anxiety disorders by combining multiple data sets with in vivo experimental validation.

Background: The incidence of comorbidity between myocardial infarction (MI) and anxiety disorders is increasing. However, the biological association between them has not been fully understood.

Objective: This study aims to investigate the molecular mechanisms of comorbidity between MI and anxiety disorders and to predict their key genes and potential therapeutic drugs.

The total withanolides from the leaves of Datura stramonium L. Improves Alzheimer's disease pathology by restraining neuroinflammation through NLRP3/IL-1β/IL1R1/TOM 1 pathway.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of beta-amyloid (Aβ) peptides. Microglia-mediated neuroinflammation is one of the primary contributors to the pathogenesis of AD. Withanolides, the main constituents in the leaves of Datura stramonium L.

[Study on drug resistance and molecular typing of food-borne Staphylococcus aureus in Ningxia, 2011-2022].

Objective: To investigate the molecular typing characteristics, drug resistance status and drug resistance gene carrying of food-borne Staphylococcus aureus in Ningxia.

Methods: Staphylococcus aureus isolated from food safety risk monitoring project in Ningxia in the past ten years were collected, drug resistance was detected using microbroth dilution method, enterotoxins were detected by real-time PCR. The strains were genotyped by pulsed field gel electrophoresis(PFGE) using SmaI endonuclease.

Suspended sediment (SPS) triggers nitrogen retention by altering microbial network stability and electron transport behavior during the aerobic-anoxic transition.

NO-N transformation, the vital biological process, determines nitrogen removal and retention in aquatic environment. Suspended sediment (SPS) ubiquitous in freshwater ecosystems can accelerate the transitions from aerobic to anoxic states, inevitably impacting NO-N transformation. To elaborate on the microbial mechanism by which SPS content affected NO-N transformation, we explored nitrogen removal and retention, microbial communities, co-occurrence networks, and electron transfer behavior under different SPS content during the aerobic-anoxic transition.

The structural and functional analysis of mycobacteria cysteine desulfurase-loaded encapsulin.

Encapsulin nanocompartments loaded with dedicated cargo proteins via unique targeting peptides, play a key role in stress resistance, iron storage and natural product biosynthesis. Mmp1 and cysteine desulfurase (Enc-CD) have been identified as the most abundant representatives of family 2 encapsulin systems. However, the molecular assembly, catalytic mechanism, and physiological functions of the Mmp1 encapsulin system have not been studied in detail.

A method for dynamically adjusting the difficulty of rehabilitation training tasks driven by attention level.

Enhancements in the rehabilitation of motor and cognitive functions are significantly attainable through proactive patient engagement. The difficulty of rehabilitation tasks and the environment in which they are conducted directly impact patient motivation. Consequently, this study introduces a dynamic difficulty adjustment method for rehabilitation training tasks based on attention levels, designed to adjust task difficulty in real-time and augment the focus of participants on their training tasks.

Independent and differential effects of arbuscular mycorrhizal fungal composition and plant pathogens on plant traits and nitrogen uptake.

Arbuscular mycorrhizal fungi (AMF), as microbial mutualists, interact with various microbial taxa, including pathogens, and significantly shape the ecology and evolution of their host species. However, how AMF and pathogens jointly or independently affect plant traits and nitrogen uptake remains unclear. Here, we conducted a factorial experiment with three AMF treatments (AMF-free-control, , and a mixture of AMF species of and ), four plant-pathogen pairs, each under two pathogen treatments (one pathogen and a pathogen-free control).

MR perfusion characteristics of pseudoprogression in brain tumors treated with immunotherapy - a comparative study with chemo-radiation induced pseudoprogression and radiation necrosis.

Purpose: Pseudoprogression is an atypical imaging pattern of response to immunotherapy in patients with brain tumors. MR perfusion studies in this field are limited. The purpose of our study is to compare the perfusion features between pseudoprogression lesions in malignant gliomas and brain metastases treated with immunotherapy (iPsP) and the pseudoprogression after chemo-radiation therapy and radiation necrosis after radiation treatment (ChR-PsP & RN).

Literature review of the clinical features of sulfasalazine-induced drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome (DRESS/DIHS).

Background: Sulfasalazine (SSZ) is commonly prescribed for the treatment of ulcerative colitis, rheumatoid arthritis, and ankylosing spondylitis. However, it can also trigger a severe drug reaction known as Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) or Drug-Induced Hypersensitivity Syndrome (DIHS). This article aims to analyze the clinical characteristics of DRESS/DIHS induced by SSZ and provide evidence for clinical diagnosis, treatment, and prevention.

Recent Progress and Challenges of Li-Rich Mn-Based Cathode Materials for Solid-State Lithium-Ion Batteries.

Li-rich Mn-based (LRM) cathode materials, characterized by their high specific capacity (>250 mAh g¹) and cost-effectiveness, represent promising candidates for next-generation lithium-ion batteries. However, their commercial application is hindered by rapid capacity degradation and voltage fading, which can be attributed to transition metal migration, lattice oxygen release, and the toxicity of Mn ions to the anode solid electrolyte interphase (SEI). Recently, the application of LRM cathode in all-solid-state batteries (ASSBs) has garnered significant interest, as this approach eliminates the liquid electrolyte, thereby suppressing transition metal crosstalk and solid-liquid interfacial side reactions.

A Comprehensive Review on Iron-Based Sulfate Cathodes for Sodium-Ion Batteries.

Sodium-ion batteries (SIBs) are advantageous for large-scale energy storage due to the plentiful and ubiquitous nature of sodium resources, coupled with their lower cost relative to alternative technologies. To expedite the market adoption of SIBs, enhancing the energy density of SIBs is essential. Raising the operational voltage of the SIBs cathode is regarded as an effective strategy for achieving this goal, but it requires stable high-voltage cathode materials.

New Insight into the Related Candidate Genes and Molecular Regulatory Mechanisms of Waterlogging Tolerance in Tree Peony .

Research on the waterlogging tolerance mechanisms of helps us to further understand these mechanisms in the root system and enhance its root bark and oil yields in southern China. In this study, root morphological identification, the statistics of nine physiological and biochemical indicators, and a comparative transcriptome analysis were used to investigate the waterlogging tolerance mechanism in this plant. As flooding continued, the roots' vigor dramatically declined from 6 to 168 h of waterlogging, the root number was extremely reduced by up to 95%, and the number of roots was not restored after 96 h of recovery.