EGCG inhibits the oxidative damage induced by TiO2-NPs in human colon cell lines.

To assess the protective effects of (-)-Epigallocatechin-3-gallate (EGCG), a natural antioxidant, against cellular oxidative damage induced by titanium dioxide nanoparticles (TiO2-NPs), Human Colon cells NCM460 and Colon Cancer cells SW620 were selected for this study. The cells were divided into three groups: control group, TiO2-NPs (80 μg/mL) exposure group, and EGCG (20 μmol/L)+TiO2-NPs (80 μg/mL) co-exposure group. The study evaluated the precipitation rate of TiO2-NPs influenced by EGCG in a cell-free system.

Regulation of multilayer long crystalline MoS by NiO-modified AlO for improved hydrodesulfurization of COS.

Activated alumina-based composite oxide support is a commonly used support in hydrodesulfurization (HDS) catalysts, which not only retains the performance advantages of each component in the composite oxide support, but also significantly improves the defects of a single activated alumina support, such as the strong metal-support force of interaction. In this study, NiO-AlO composite support was prepared by introducing NiO-modified AlO, and MoS/NiO-AlO catalysts were prepared for the hydrodesulfurization of COS by liquid phase reduction method. In the COS hydrogenation reaction, the MoS/NiO-AlO catalyst achieved complete conversion of COS at 220 °C and showed more than 99.

Effect of electroacupuncture on metabolic alterations in the hippocampus and dorsal raphe nucleus of Wistar Kyoto rats.

Depression is underpinned by a complex pathogenesis that involves the hippocampus and dorsal raphe nucleus (DRN) of the central nervous system. Although electroacupuncture (EA) is proven to be safe and effective for alleviating depression symptoms and causes minimal side effects its underlying therapeutic mechanism remains unclear. In this study, we performed targeted metabolomics to identify metabolite alterations in the hippocampus and DRN of Wistar Kyoto (WKY) rats and elucidate the role and potential mechanism of action of EA.

Downregulation of cardiac inflammation via the CaMKII δ/NF-κB pathway in heart failure by Lonicerae Japonicae Flos and Angelicae Sinensis Radix.

Background: Inflammation serves an essential function in the occurrence and progression of heart failure (HF), especially in the early stage. Lonicerae japonicae Flos (LJF), Angelicae sinensis Radix (ASR), and their compatibility (LJF+ASR) can inhibit excessive inflammation and have significant cardioprotective effects. However, the primary active ingredients and mechanism of LJF and ASR in anti-inflammatory and anti-HF effect remain to be elucidated.

How to develop nature-based solutions for revegetation on abandoned farmland in the Loess Plateau of China?

Adequate revegetation of abandoned farmland acts as a defence against desertification and soil loss, and can help remove carbon dioxide in the atmosphere, thereby playing an important role in regulating regional climate change. Legume, a nitrogen-fixation species, which could effectively improve vegetation coverage to control soil erosion, was widely used for revegetation. However, the dynamics of soil and plant development after legume introduction on abandoned farmland remain unclear.

Design and performance of a magnetic bottle electron spectrometer for high-energy photoelectron spectroscopy.

We describe the design and performance of a magnetic bottle electron spectrometer (MBES) for high-energy electron spectroscopy. Our design features a 2 m long electron drift tube and electrostatic retardation lens, achieving sub-electronvolt (eV) electron kinetic energy resolution for high energy (several hundred eV) electrons with a close to 4π collection solid angle. A segmented anode electron detector enables the simultaneous collection of photoelectron spectra in high resolution and high collection efficiency modes.

BIRC5 as a prognostic and diagnostic biomarker in pan-cancer: an integrated analysis of expression, immune subtypes, and functional networks.

Introduction: BIRC5 (Survivin) is a crucial anti-apoptotic protein overexpressed in various cancers, promoting tumor growth and treatment resistance. This study investigates its expression across 33 cancer types and explores its diagnostic, prognostic, and immune-related significance.

Methods: We analyzed RNA-seq data from TCGA and protein expression data from the Human Protein Atlas.

Molecular and Cellular Mechanisms of Photoperiod and Thermo-sensitive Genic Male Sterility in Plants.

Photo-thermosensitive genic male sterile (P/TGMS) lines display male sterility under high temperature/long-day light conditions, and male fertility under low temperature/short-day light conditions. P/TGMS lines are the fundamental basis for the two-line hybrid breeding, which has notably increased the yield potential and grain quality of rice cultivars. In this review, we focus on the research progress on photoperiod and thermosensitive genic male sterility in plants.

The association between dietary diversity and patterns in Chinese university students with abnormal uterine bleeding: a cross-sectional study.

Background: Abnormal uterine bleeding (AUB) is a common gynecological issue during reproductive years. Researches on how dietary diversity and patterns influence AUB in Chinese university students are limited, with some studies not clearly defining irregular menstruation. This research investigated the incidence of AUB according to the International Federation of Gynecology and Obstetrics criteria and sought to identify preventative factors via online questionnaires.

An ultrasound image segmentation method for thyroid nodules based on dual-path attention mechanism-enhanced UNet+.

Purpose: This study aims to design an auxiliary segmentation model for thyroid nodules to increase diagnostic accuracy and efficiency, thereby reducing the workload of medical personnel.

Methods: This study proposes a Dual-Path Attention Mechanism (DPAM)-UNet++ model, which can automatically segment thyroid nodules in ultrasound images. Specifically, the model incorporates dual-path attention modules into the skip connections of the UNet++ network to capture global contextual information in feature maps.

Comprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer.

Caveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. Cavin family proteins are indispensable for caveolar formation and function. An increasing number of studies have found that cavins are involved in tumor growth, invasion, metastasis, and angiogenesis and may have dual roles in the regulation of cancer.

Long non-coding RNA OIP5-AS1 protects neurons from ischemia-reperfusion injury and inhibits neuronal apoptosis through TAB-2.

Ischemic stroke represents a highly perilous cerebrovascular disorder, involving a variety of complex pathophysiological mechanisms. OIP5 antisense RNA 1 (OIP5-AS1) is a long non-coding RNA (LncRNA) that has been shown to play a pivotal role in a variety of disease systems. However, there are relatively few studies on ischemic stroke.

Sorption of tetracycline antibiotics by microplastics, associated mechanisms, and risk assessments.

In this study, we selected polyvinyl chloride (PVC), polyethylene (PE), and polystyrene (PS) as representative microplastics (MPs) to systematically investigate the sorption behavior of tetracycline (TC) antibiotics by MPs. Scanning electron microscopy, X-ray diffraction, Fourier transform-infrared spectroscopy, and adsorption experiments were applied to assess the sorption behavior of MPs. The results demonstrated that the sorption of TC by MPs was most favorable under neutral conditions, where a modest increase in the salt ion concentration enhanced the adsorption of TC by MPs.

Exploring Shared Targets in Cancer Immunotherapy and Cancer-Induced Bone Pain: Insights from Preclinical Studies.

Cancer casts a profound shadow on global health, with pain emerging as one of the dominant and severe complications, particularly in advanced stages. The effective management of cancer-induced pain remains an unmet need. Emerging preclinical evidence suggests that targets related to tumor immunotherapy may also modulate cancer-related pain pathways, thus offering a promising therapeutic direction.

The Association of Fructose Metabolism With Anesthesia/Surgery-Induced Lactate Production.

Background: In elderly individuals, excessive lactate levels in the brain may be associated with the development of cognitive impairment after surgery, including delayed neurocognitive recovery (dNCR). Since the origin of this increased lactate is unknown, here we assessed associations between metabolic pathways and postoperative dNCR.

Methods: This study included 43 patients (≥60 years old) who had surgery under general anesthesia.

Quantum Otto Heat Engine Using Polar Molecules in Pendular States.

Quantum heat engines (QHEs) are established by applying the principles of quantum thermodynamics to small-scale systems, which leverage quantum effects to gain certain advantages. In this study, we investigate the quantum Otto cycle by employing the dipole-dipole coupled polar molecules as the working substance of QHE. Here, the molecules are considered to be trapped within an optical lattice and located in an external electric field.

Enzyme Engineering: Performance Optimization, Novel Sources, and Applications in the Food Industry.

This review summarizes the latest progress in enzyme preparation, including enzyme design and modification technology, exploration of new enzyme sources, and application of enzyme preparation in food processing, detection, and preservation. The directed evolution technology improved the stability and catalytic efficiency of enzymes, while enzyme immobilization technology enhanced reusability and industrial applicability. Extremozymes and biomimetic enzymes exhibit excellent performance under harsh conditions.

Ultrasound-Activated Precise Sono-Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis.

Immune checkpoint inhibitors have demonstrated remarkable efficacy across various cancer types. However, immune-related adverse events (irAEs) pose a significant challenge in immunotherapy, particularly the associated pneumonia as the primary adverse reaction, which can lead to irreversible pulmonary fibrosis. Additionally, monotherapy with programmed death ligand (PD-L1) inhibitors has shown limited effectiveness.

Decellularized adipose matrix hydrogel-based in situ delivery of antagomiR-150-5p for rat abdominal aortic aneurysm therapy.

Abdominal aortic aneurysm (AAA) is a progressive aortic disease featured by inflammation, vascular smooth muscle cells (VSMCs) depletion, and elastin degradation. MicroRNAs were related to AAA formation, which bring the approach for precise and targeted drug therapy for AAA. We developed a new strategy based on decellularized adipose matrix (DAM) hydrogel immobilized on the adventitia to release antagomiR-150-5p for preventing the AAA development.

Comparison of Synapse 3D system (Version 4.4) and DirectPath system (Version 2.0) in virtual bronchoscopic navigation application for peripheral pulmonary nodules.

Background: Differences between virtual bronchoscopic navigation (VBN) systems and their impacts on the diagnostic yield of transbronchial biopsy (TBB) of peripheral pulmonary nodules (PPNs) remain unclear.

Objectives: To compare the Synapse 3D system (Version 4.4, Fujifilm, Japan) and DirectPath system (Version 2.

CircSATB2 modulates fear extinction memory via Robo3-driven synaptic plasticity.

Circular RNAs (circRNAs) are novel class of stable regulatory RNAs abundantly expressed in the brain. However, their role in fear extinction (EXT) memory remains largely unexplored. To investigate the mechanisms of Circular Special AT-rich Sequence Binding Protein 2 (circSatb2) in EXT memory, we constructed a lentivirus overexpressing circSatb2 and injected it into the infralimbic prefrontal cortex (ILPFC) of the mouse brain.

Learning Curve of Uniportal Compared With Biportal Endoscopic Techniques for the Treatment of Lumbar Disc Herniation.

Objectives: Currently, unilateral biportal endoscopic (UBE) and uniportal full-endoscopic (UFE) techniques for the treatment of lumbar disc herniation (LDH) are gaining popularity. However, studies investigating the number of surgeries needed for surgeons to achieve proficiency in these procedures are lacking. This study aims to compare the early learning curve for UBE and UFE when treating LDH.