Bacterial extracellular vesicles (EVs) play a pivotal role in host-microbe communication. , a symbiotic bacterium essential for intestinal health, is hypothesized to exert its effects via EVs. Here, we successfully isolated and characterized EVs derived from (Am-EVs) using ultracentrifugation.
View Article and Find Full Text PDFSchizophrenia is a complex disorder characterized by disruptions in cognition, behavior, and emotions. Extensive research has uncovered alterations in a single modality (either the brain structure or function) in schizophrenia. However, the limitation is that a single modality could not offer a synchronous result between the brain structure and function because of different samples.
View Article and Find Full Text PDFJ Bone Miner Res
February 2025
The abnormal mechanical stress has been considered as a major contributor of temporomandibular joint osteoarthritis (TMJOA), but the mechanism by which it leads to the degeneration of condylar cartilage remains elusive. The double-stranded (dsDNA)-sensing cGAS/STING pathway serves as a response mechanism in many sterile inflammatory responses. In the present study, we found that mechanical stress exerted on condyle chondrocytes induced dsDNA leakage from mitochondria to cytoplasm to activate STING.
View Article and Find Full Text PDFHemophilia poses distinct challenges to wound healing, primarily due to uncontrolled bleeding and delayed tissue repair. This study explored a novel tannic acid-thioctic acid (TATA) hydrogel, enriched with exosomes derived from bone marrow mesenchymal stem cells, as a therapeutic strategy for enhancing skin wound healing in a hemophilia model. The hydrogel exhibited robust hemostatic efficacy, potent antioxidant activity, and the capacity to modulate the inflammatory microenvironment.
View Article and Find Full Text PDFDysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD). Aberrant mitochondrial fission induced by dynamin-related protein 1 (DRP1) causes mitochondrial dysfunction in dopaminergic (DA) neurons. However, the mechanism of DRP1 activation and its role in PD progression remain unclear.
View Article and Find Full Text PDFObjectives: To determine acceptance of potential risks in orthodontic treatment and whether it could be affected by personality traits of patients.
Materials And Methods: Two hundred sixty-one adult participants consulting for orthodontic treatment were involved in this cross-sectional study. Acceptance of 18 orthodontic risks was investigated with a structured questionnaire.
Sarcopenia and physical deconditioning are common complications in patients with liver cancer, which are frequently caused by insufficient physical activity and poor nutritional status, resulting in physical frailty and a significant impact on the patient's physical fitness. Notably, sarcopenia, frailty, and poor cardiopulmonary endurance have all been linked to higher mortality rates among patients with liver cancer. Exercise intervention significantly improves various health parameters in liver cancer patients, including metabolic syndrome, muscle wasting, cardiorespiratory endurance, health-related quality of life, and reduction in hepatic venous pressure gradient.
View Article and Find Full Text PDFEpilepsy is a common neurological disorder in which abnormal brain waves propagate rapidly in the brain in the form of a graph network during seizures, and seizures are extremely sudden. So, designing accurate and reliable prediction methods can provide early warning for patients, which is crucial for improving their lives. In recent years, a large number of studies have been conducted using deep learning models on epileptic open electroencephalogram (EEG) datasets with good results, but due to individual differences there are still some subjects whose seizure features cannot be accurately captured and are more difficult to differentiate, with poor prediction results.
View Article and Find Full Text PDFBrain Imaging Behav
February 2025
Resting-state functional connectivity has become a valuable tool in studying post-stroke aphasia (PSA). However, the specific distribution of increased functional connectivity areas (IFCAs) in PSA patients after speech-language therapy (SLT) remains unclear, particularly compared with the intrinsic brain network (IBN) observed in healthy controls. This study aimed to explore the effects of SLT and spontaneous recovery on functional connectivity changes in the brain.
View Article and Find Full Text PDFPer- and polyfluoroalkyl substances (PFAS) pose potential health risks to lipid metabolism, but the effects of emerging PFAS alternatives, particularly in children, remain unclear. This cross-sectional study investigated the association between emerging PFAS exposure and lipid levels in 294 Chinese children aged 7-10 years, analyzing blood samples for 14 PFAS and lipid profiles, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB). Exposure to 6:2 Cl-PFESA, PFO4DA, and PFO5DoDA was associated with higher TC, TG, and LDL levels, with PFO4DA increasing the TC by 1.
View Article and Find Full Text PDFObjective: This cross-sectional study aimed to investigate the association between insomnia and the presence of temporomandibular disorders (TMD) and its subtypes in orthodontic patients.
Methods: A total of 648 adult orthodontic patients (158 males and 490 females, median age 26) were included and completed a questionnaire containing sociodemographic information, insomnia severity index (ISI), the five major temporomandibular disorder symptoms (5Ts) checklist, and self-reported sleep bruxism. Presence of insomnia and TMD of the included patients was determined according to the diagnostic criteria, and statistical analyses were conducted as appropriate to compare ISI-related scores between TMD and non-TMD participants.
Arsenic, a well-known environmental endocrine disruptor, exerts interference on the body's endocrine system. Our previous investigations have demonstrated that chronic exposure to sodium arsenite (NaAsO) can induce thyroid damage and dysfunction in Sprague-Dawley (SD) rats. Vitamin D (VD) is an indispensable fat-soluble vitamin that plays a crucial role in maintaining thyroid health.
View Article and Find Full Text PDFSynucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, are characterized by the aggregation of α-synuclein. Variations in brain distribution allow for differentiation among these diseases and facilitate precise clinical diagnosis. However, distinguishing between synucleinopathies and Parkinsonism with tauopathies poses a challenge, significantly impacting clinical drug development.
View Article and Find Full Text PDFBackground: There is a growing focus on researching healthcare services to identify factors associated with satisfaction in family contract services in China. However, previous satisfaction studies have mainly focused on the primary healthcare. Currently, the primary healthcare service capacity in China is relatively insufficient, necessitating the involvement of upper-level hospitals in contracted services Thus, the study significantly deepens and broadens previous research on satisfaction in family contract services of hospital.
View Article and Find Full Text PDFTransl Psychiatry
December 2024
Bipolar disorder (BD) is a neuropsychiatric disorder characterized by severe disturbance and fluctuation in mood. Dynamic functional connectivity (dFC) has the potential to more accurately capture the evolving processes of emotion and cognition in BD. Nevertheless, prior investigations of dFC typically centered on larger time scales, limiting the sensitivity to transient changes.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
December 2024
Background: Breastfeeding is the optimal source of nutrition for infants and young children, essential for their healthy growth and development. However, a gap in cohort studies tracking breastfeeding up to six months postpartum may lead caregivers to miss critical intervention opportunities.
Methods: This study conducted a three-wave prospective cohort analysis to examine maternal breastfeeding trajectories within the first six months postpartum and to develop risk prediction models for each period using advanced machine learning algorithms.
Objective: To evaluate the impact of cardiac arrest time (CAT) in brain-dead donors on graft and recipient outcomes following liver transplantation.
Background: The outcome of livers from brain-dead donors with a history of cardiac arrest (CA) remains controversial, and the duration of the CAT has never been evaluated.
Methods: A retrospective review of data from the Scientific Registry of Transplant Recipients between 2003 and 2022 was conducted.
Background: As a typical medicinal food homology species, Chinese herbal medicine Astragali radix (AR) has been widely used to regulate the human immune system worldwide. However, the human immunomodulation of AR and its corresponding mechanisms remain unclear.
Methods: First, following a fortnight successive AR administration, the changes in immune cytokines and immune cells from 20 healthy human subjects were used as immune indicators to characterize the immunomodulatory effects of AR.
Background: ICU-acquired weakness (ICU-AW) is a common complication among ICU patients. We used machine learning techniques to construct an ICU-AW inflammatory factor prediction model to predict the risk of disease development and reduce the incidence of ICU-AW.
Methods: The least absolute shrinkage and selection operator (LASSO) technique was used to screen key variables related to ICU-AW.
Am J Physiol Endocrinol Metab
February 2025
Diabetic kidney disease (DKD) is a severe diabetic microvascular complication featured by chronic low-grade inflammation. Roux-en-Y gastric bypass (RYGB) surgery has gained importance as a safe and effective surgery to treat DKD. Bile acids significantly change after RYGB, which brings a series of metabolic benefits, but the relationship with the improvement of DKD is unclear.
View Article and Find Full Text PDFThis retrospective study aimed to comprehensively investigate the impact of non-surgical treatments on condylar osseous changes in adult patients with degenerative joint disease (DJD). Radiographic and clinical data were collected for analysis. Cone-beam computed tomography (CBCT) was used to diagnose DJD, including flattening, erosion, osteophytes, sclerosis and cysts.
View Article and Find Full Text PDFArsenic is a ubiquitous hazardous metalloid that poses a significant threat to human health. Although researchers have investigated the detrimental effects of arsenic on the thyroid, a comprehensive exploration of its toxicological impact and underlying molecular mechanisms remains to be conducted. Both this study and our previous reports demonstrated that chronic exposure to sodium arsenite (NaAsO) results in histological impairment and dysfunction of the thyroid glands in Sprague-Dawley (SD) rats.
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