Biomed Phys Eng Express
December 2024
In this paper, we propose the design of extending collimators aimed at reducing the radiation dose received by patients with normal tissues and protecting organs at risk in Boron Neutron Capture Therapy (BNCT). Three types of extended collimators are studied: Type 1, which is a traditional design; Type 2, which is built upon Type 1 by incorporating additional polyethylene material containing lithium fluoride (PE(LiF)); Type 3, which adds lead (Pb) to Type 1. We evaluated the dose distribution characteristics of the above-extended collimators using Monte Carlo methods simulations under different configurations: in air, in a homogeneous phantom, and a humanoid phantom model.
View Article and Find Full Text PDFRodents represent the most abundant order of mammals, exhibiting remarkable diversity in morphology, habitats, behaviors, and hosted pathogens. Significant attention is currently focused on rodents as experimental animals for biomedical research. However, numerous aspects of rodents remain unexplored, such as their potential in unconventional biomedical models, molecular underpinnings of intriguing complex phenotypes, adaptations to environment or climate change, and host-pathogen interactions and arms race evolution.
View Article and Find Full Text PDFAims: Noninvasive myocardial work offers a promising echocardiographic method to evaluate left ventricular (LV) function as it integrates myocardial deformation and afterload. The study sought to investigate the association of myocardial work indices with post-operative LV dysfunction in patients with chronic severe aortic regurgitation (AR).
Methods And Results: Pre-operative LV ejection fraction (LVEF), LV global work index (LV GWI), LV global constructive work (LV GCW), LV global wasted work (LV GWW), and LV global work efficiency (LV GWE) were measured.
A physical map of Aegilops geniculata chromosome 7M was constructed, and a novel purple coleoptile gene was localized at 7MS bin FL 0.60-0.65 by development of wheat-Ae.
View Article and Find Full Text PDFInvestigating how multiple invasive fish species with similar ecological traits respond to different environmental conditions is crucial to understanding their successful invasion and coexistence. Here, we used stomach content analysis and stable isotope analysis to analyse the effects of water level fluctuation on the trophic niche plasticity of three dominant co-occurring invasive tilapia species (Coptodon zillii, Sarotherodon galilaeus, and Oreochromis niloticus) in the Shanmei Reservoir, southern China. We found that the tilapia species exhibited an iliophagous habit with dietary variations between the high-water (HW) and low-water (LW) level periods.
View Article and Find Full Text PDFPerovskite heterojunctions combine the advantages of two different components but suffer difficulties in the tightness of interconnection and limitation of material selection. Here we report an electric field-driven ion deposition (EFID) strategy that controllably deposits perovskite ions on heterogeneous single crystals to form a gradient heterojunction with tight integration. The interconnection force of the gradient heterojunction by the EFID method is much better than that of the solution-grown heterojunction, which is easily decomposed.
View Article and Find Full Text PDFRationale: Multiple primary cancer is common in clinical practice, but its diagnosis process is complicated, and relevant genetic testing is required to assist in diagnosis when necessary. The formulation of treatment strategies for multiple primary cancer is a highly personalized process. In this article, we introduce a case of a patient with rectal cancer and gastric cancer who was diagnosed with multiple primary cancers, to investigate and explore the clinical application value of next-generation sequencing (NGS) testing in patients with multiple primary gastric and colorectal cancers.
View Article and Find Full Text PDFObjective: We aimed to explore the predictive significance of the nutritional indexes in the occurrence of postoperative leakage after gastrectomy, aiming to develop and validate a predictive nomogram for assessing the risk of these complications.
Methods: Patients undergoing radical gastrectomy for gastric cancer were studied, using data from The Sixth Affiliated Hospital of Sun Yat-sen University (2019-2022, n = 1075) for nomogram development and an external cohort from Sun Yat-sen University Cancer Center (2022, n = 286) for validation. The model, focusing on postoperative leakage, was constructed through univariate and backward stepwise regression.
Background: It is unknown whether acral melanomas (AMs) associated with pre-existing nevi have similar risk to other AMs.
Objective: To compare risk of recurrence and death between AMs associated with pre-existing nevi and de novo AMs.
Methods: We conducted a multicenter retrospective cohort study involving patients diagnosed with AMs between February 2011 and November 2022.
Electrostatic catalysis uses an external electric field (EEF) to rearrange the charge distribution to boost reaction rates and selectively produce certain reaction products in small-molecule reactions (e.g., Diels-Alder addition), requiring a 10 MV/cm field aligned with the reaction axis.
View Article and Find Full Text PDFBackground: Precisely localizing the seizure onset zone (SOZ) is critical for focal epilepsy surgery. Existing methods mainly focus on high-frequency activities in stereo-electroencephalography, but often fail when seizures are not driven by high-frequency activities. Recognized as biomarkers of epileptic seizures, ictal spikes in SOZ induce epileptiform discharges in other brain regions.
View Article and Find Full Text PDFObjective: LncRNA plays a significant role in regulating feed efficiency. This study aims to explore the key long non-coding RNAs, associated genes, and pathways in pigs with extreme feed efficiencies.
Methods: We screened pigs with extremely high and low RFI through a 12-week animal growth trial and then conducted transcriptome analysis on their liver and ileum tissues.
Background: Inflammation is an important driver of hypertension with numerous components, and there is a paucity of research on the specific inflammatory factors that induce hypertension; therefore, we wanted to investigate the relationship between specific inflammatory factors and hypertension.
Purpose: A two-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between systemic inflammatory regulators and hypertension (primary or secondary types).
Method: a large-scale, published genome-wide association study (GWAS) meta-analysis encompassing 41 cytokines (involved 8,293 Finnish participants from three independent population cohorts: the Cardiovascular Risk in Young Finns Study (YFS), FINRISK1997, and FINRISK2002.
ACS Appl Mater Interfaces
October 2024
Purpose: The objective of this retrospective cohort study was to investigate the predictive value of stress-induced hyperglycemia parameters for delayed healing after tibial fracture post-surgery.
Methods: A cohort of 108 participants who underwent surgical intervention for tibial fractures caused by trauma was included in this retrospective study. Data collected from electronic medical records encompassed demographic characteristics, bone healing assessments, stress-induced hyperglycemia parameters, inflammatory markers, and stress-related hormones.
Sorting recyclable trash is critical to reducing energy consumption and mitigating environmental pollution. Currently, trash sorting heavily relies on manpower. Computer vision technology enables automated trash sorting.
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