Targeting WDR5/ATAD2 signaling by the CK2/Ikaros axis demonstrates therapeutic efficacy in T-ALL.

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a poor prognosis and limited options for targeted therapies. Identifying new molecular targets to develop novel therapeutic strategies is the pressing immediate issue in T-ALL. Here, we observed high expression of WD Repeat-Containing Protein 5 (WDR5) in T-ALL; with in vitro and in vivo models we demonstrated the oncogenic role of WDR5 in T-ALL by activating cell cycle signaling through its new downstream effector, ATPase family AAA domain-containing 2 (ATAD2).

A Bibliometric Analysis on Research Progress of Earthworms in Soil Ecosystems.

The earthworm, as a soil engineer, plays highly important roles in the soil ecosystem for shaping soil structure, promoting soil fertility, regulating microbial community composition and activities and decomposing soil pollutants. However, the research progresses on this important soil fauna have rarely been reviewed so far. Therefore, we conducted a bibliometric analysis of the literature published during 1900-2022, which was collected from the Web of Science Core Collection (WoS).

Tackling Energy Loss in Organic Solar Cells via Volatile Solid Additive Strategy.

The energy loss induced open-circuit voltage (V) deficit hampers the rapid development of state-of-the-art organic solar cells (OSCs), therefore, it is extremely urgent to explore effective strategies to address this issue. Herein, a new volatile solid additive 1,4-bis(iodomethyl)cyclohexane (DIMCH) featured with concentrated electrostatic potential distribution is utilized to act as a morphology-directing guest to reduce energy loss in multiple state-of-art blend system, leading to one of highest efficiency (18.8%) at the forefront of reported binary OSCs.

Achieving single-cell-resolution lineage tracing in zebrafish by continuous barcoding mutations during embryogenesis.

Unraveling the lineage relationships of all descendants from a zygote is fundamental to advancing our understanding of developmental and stem cell biology. However, existing cell barcoding technologies in zebrafish lack the resolution to capture the majority of cell divisions during embryogenesis. A recently developed method, a substitution mutation-aided lineage-tracing system (SMALT), successfully reconstructed high-resolution cell phylogenetic trees for Drosophila melanogaster.

Iodide/triiodide redox shuttle-based additives for high-performance perovskite solar cells by simultaneously passivating the cation and anion defects.

Halide perovskite solar cells (PSCs) have received remarkably increasing interests due to their facile fabrication procedures, use of cost-effective raw materials, and high power conversion efficiencies (PCEs) during the past 10 years. Nevertheless, the state-of-the-art organic-inorganic PSCs suffer from high defect concentration and inferior humid/thermal stability, significantly restricting the widespread applications of PSCs. More specifically, point defects including metallic lead (Pb) and halide iodine (I) are easily generated in Pb/I-based PSCs during fabrication processes and operational conditions due to the inferior interaction between the anions and cations in halide perovskites and promote detrimental carrier recombination and ion migration, leading to inferior PCEs and durability of the PSCs.

Pancancer analysis of SKA1 mutation and its association with the diagnosis and prognosis of human cancers.

This study aims to explore the role of SKA1 in cancer diagnosis and prognosis and to investigate the mechanism by which SKA1 affects the malignant behaviors of ovarian cancer. Herein, we analyzed the oncogenic role of SKA1 at pan-cancer level by multiple informatics databases and verified the analysis by in vitro experiments. As a result, SKA1 was upregulated across cancers and was related to poor clinical outcome and immune infiltration.

Monovalent Copper Cation Doping Enables High-Performance CsPbIBr-Based All-Inorganic Perovskite Solar Cells.

Organic-inorganic perovskite solar cells (PSCs) have delivered the highest power conversion efficiency (PCE) of 25.7% currently, but they are unfortunately limited by several key issues, such as inferior humid and thermal stability, significantly retarding their widespread application. To tackle the instability issue, all-inorganic PSCs have attracted increasing interest due to superior structural, humid and high-temperature stability to their organic-inorganic counterparts.

Recent Advances in Nanostructured Inorganic Hole-Transporting Materials for Perovskite Solar Cells.

Organic-inorganic halide perovskite solar cells (PSCs) have received particular attention in the last decade because of the high-power conversion efficiencies (PCEs), facile fabrication route and low cost. However, one of the most crucial obstacles to hindering the commercialization of PSCs is the instability issue, which is mainly caused by the inferior quality of the perovskite films and the poor tolerance of organic hole-transporting layer (HTL) against heat and moisture. Inorganic HTL materials are regarded as promising alternatives to replace organic counterparts for stable PSCs due to the high chemical stability, wide band gap, high light transmittance and low cost.

Thiourea with sulfur-donor as an effective additive for enhanced performance of lead-free double perovskite photovoltaic cells.

Lead-free inorganic CsAgBiBr double perovskites have emerged as promising materials in perovskite solar cells (PSCs) to tackle the inferior stability and toxicity issues of organic-inorganic hybrid PSCs. However, the power conversion efficiencies (PCEs) of CsAgBiBr solar cells are remarkably restricted by the intrinsic and extrinsic defects of CsAgBiBr films. More specifically, the fast crystallization process in the formation of CsAgBiBr films strongly prevents the homogeneous growth of perovskite crystals, leading to inferior CsAgBiBr film quality.

Mix-cropping of rice and water mimosa (Neptunia oleracea Lour.) increases rice photosynthetic efficiency, yield, grain quality and soil available nutrients.

Background: Cereal cultivation with legumes plays an important role in improving biodiversity and productivity. However, there are limited references concerning rice/legume mix-cropping in paddy fields. An aquatic leguminous plant, water mimosa (Neptunia oleracea Lour.

Water mimosa (Neptunia oleracea Lour.) can fix and transfer nitrogen to rice in their intercropping system.

Background: Cereal-legume intercropping systems are an environmentally friendly practice in sustainable agriculture. However, research on the interspecific interaction of nitrogen (N) between rice and aquatic legumes has rarely been undertaken. To address this issue, a pot experiment was conducted to investigate N utilization and the N interaction between rice and water mimosa (Neptunia oleracea Lour.

Reduced pests, improved grain quality and greater total income: benefits of intercropping rice with Pontederia cordata.

Background: Intercropping, which is growing two or more different crops in the same field simultaneously, is an effective traditional agricultural practice for productivity, resource utilization, and pest control. However, study on intercropping in paddy fields is limited. So in this study, field experiments of 2 years/four seasons (early and late seasons in 2016 and 2017) were conducted to examine the effects of rice-Pontederia cordata intercropping on rice plant growth, pest control, yield, income, and grain quality.

Acid Rain Increases Impact of Rice Blast on Crop Health via Inhibition of Resistance Enzymes.

Worldwide, rice blast () causes more rice crop loss than other diseases. Acid rain has reduced crop yields globally for nearly a century. However, the effects of acid rain on rice- systems are still far from fully understood.

Promoting the Efficiency and Stability of CsPbIBr-Based All-Inorganic Perovskite Solar Cells through a Functional Cu Doping Strategy.

Although organic-inorganic halide perovskite solar cells (PSCs) have shown dramatically enhanced power conversion efficiencies (PCEs) in the last decade, their long-term stability is still a critical challenge for commercialization. To address this issue, tremendous research efforts have been devoted to exploring all-inorganic PSCs because of their intrinsically high structural stability. Among them, CsPbIBr-based all-inorganic PSCs have drawn increasing attention owing to their suitable band gap and favorable stability.

Quality dependence of litter decomposition and its carbon, nitrogen and phosphorus release under simulated acid rain treatments.

Litter decomposition is of utmost importance to elemental cycling in terrestrial ecosystems, with litter quality being frequently considered to predominantly control litter decomposition. However, how acid rain (AR) would affect litter decomposition and its elements release remains inconclusive, although AR has widely occurred in Europe, North America, and East Asia. This study was conducted to observe leaf litter decomposition and release of carbon (C), nitrogen (N), and phosphorus (P) of three crops (maize, rice, and soybean) under simulated AR treatments.

Invasive Chromolaena odorata species specifically affects growth of its co-occurring weeds.

Plant-plant interaction is essential to weed invasion success and is related to impacts on the environment. To understand interactions of the well-known invasive plant siamweed (Chromolaena odorata) and its neighbors (exotic Praxelis clematidea and native cadillo) in South China, and their competitive mechanisms above- and belowground, a multicultivation experiment was conducted. Competitive indices, plant morphological traits, soil nutrient contents, enzyme activities, and microbial biomass were measured.

Crop-litter type determines the structure and function of litter-decomposing microbial communities under acid rain conditions.

Acid rain has been one of the major environmental problems in industrial countries. While it may affect the litter decomposition, a highly important microbial-driven biogeochemical process, knowledge about the impact of acid rain on litter-decomposing microbial communities and their functions remains unclear. Therefore, this experiment was conducted to investigate how acid rain treatments would alter microbial communities and their functions during litter decomposition of three major commodity crops (maize, rice, and soybean) for six months from June to December 2018.

Chain structure and immunomodulatory activity of a fructosylated chondroitin from an engineered Escherichia coli K4.

Polysaccharide K4 expressed from E. coli K4 has a similar structure with chondroitin, which can be used as a precursor to produce chondroitin sulfates. Here, we investigated the structure, conformation and biological activity of K4 from an engineered strain with high productivity.

Theoretical predicted high-thermal-conductivity cubic SiN and GeN: promising substrate materials for high-power electronic devices.

Ceramic substrates play key roles in power electronic device technology through dissipating heat, wherein both high thermal conductivity and mechanical strength are required. The increased power of new devices has led to the replacement of AlO by high thermal conducting AlN and further β-SiN based substrates. However, the low mechanical strength and/or anisotropic mechanical/thermal properties are still the bottlenecks for the practical applications of these materials in high power electronic devices.

Soil properties and carbon and nitrogen pools in a young hillside longan orchard after the introduction of leguminous plants and residues.

The intensification of young hillside orchard cultivation has led to increase soil erosion and decrease soil fertility in South China. Leguminous crops are often used for improving soil properties. An approximately 2-year-long field experiment in lateritic soil in South China was conducted to evaluate the effects of legume introductions on soil properties and carbon (C) and nitrogen (N) pools.

earthworm breeding in orchards significantly improves the growth, quality and yield of papaya ( L.).

The aim of this study was to compare the effects of four fertilizer applications-control (C), chemical fertilizer (F), compost (O), and in situ earthworm breeding (E)-on the growth, quality and yield of papaya (). In this study, 5 g plant urea (CHNO, % = 46.3%) and 100 g plant microelement fertilizer was applied to each treatment.