Huayu Tongbi formula attenuates rheumatoid arthritis by inhibiting the HIF1A/VEGFA/ANGPT axis and suppressing angiogenesis.

Background: Angiogenesis, integral to the pathogenesis of rheumatoid arthritis (RA), contributes to the advancement of synovial hyperplasia, pannus formation, and bone destruction. The precise effect of the Huayu Tongbi formula (HT), a proven traditional Chinese medicine for RA treatment, on angiogenesis remains uncertain.

Purpose: To investigate the effects of HT on RA angiogenesis and the potential underlying molecular mechanisms.

Nasolacrimal Metastasis from Parotid Ductal Carcinoma Detected by F-FDG PET/CT.

A 39-year-old woman presented with left neck masses for 4 months and epiphora of the left eye for 3 weeks. Ultrasonography revealed a mass in the left parotid gland and multiple cervical lymph nodes. Biopsy of the mass in the left parotid gland revealed infiltrating ductal carcinoma.

Ten proposed measures to improve vaccination: Health care providers' perspectives on promoting the vaccination intake of children with special healthcare needs in China.

Introduction: Children with special healthcare needs (CSHCN) often experience vaccination delays or missed vaccines in China. The coverage rate of the age-appropriate National Immunisation Programme vaccine was suboptimal. This study aimed to explore attitudes, behaviours, and suggestions regarding the improvement of routine vaccination services for CSHCN among healthcare providers.

First-principles study of the effect of Bi content on the photocatalytic performance of bismuth bromide oxide-based catalysts.

A comprehensive analysis of BiOBr has been carried out using first-principles density-functional theory (DFT) to explore the electronic structure, energy band structure, and essential properties related to its photocatalytic performance. DFT calculations reveal that BiOBr, BiOBr, BiOBr, BiOBr, BiOBr, and BiOBr have different indirect bandgap values of 2.46 eV, 2.

Melatonin Promotes Yield Increase in Wheat by Regulating Its Antioxidant System and Growth Under Drought Stress.

Drought stress constitutes a major challenge to wheat production. Melatonin plays a vital role in plants' resistance to drought stress. Nevertheless, the influence of melatonin seed coating on the drought resistance ability of wheat remains unclear.

Effects of MIR-451 on LKB1-AMPK Signal Pathway and Oxidative Stress Index in Lung Cancer.

Objective: To understand the influence of MIR-451 on LKB1-AMPK signal pathway and oxidative stress index in lung cancer mice.

Methods: 40 rats were divided into four groups: ZC group (no lung cancer model), model group (lung cancer model), intervention group (rats with MiR-451 agomir injected), and NC group (rats with MiR-451 agomir control injected), 10 mice/group. The levels of MDA (malondialdehyde) and SOD (superoxide dismutase) in the four groups were detected, as well as the overall weights of the lungs and spleens.

Unloading damage evolution and rockburst risk assessment of Xuefengshan No.1 tunnel by combining multiple approaches.

Large-scale rock burst disasters often occur in high-stress and deep-buried tunnels, due to challenges in accurate forecasting and the lack of clarity regarding the underlying mechanisms largely. This study combined on-site stress drilling tests, coupled finite and discrete element simulations, and theoretical calculations to examine unloading damage, rockburst evolution, and deformation failure of the high-stress and deep-buried Xuefengshan No.1 tunnel.

Cardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis.

Objective: Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate (S1P) receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). S1P receptor expression on cardiac cells is involved in cardiac conduction. We report cardiovascular treatment-emergent adverse events (TEAEs) associated with S1P receptor modulators and other cardiovascular events in the etrasimod UC clinical programme.

MYB represses ζ-globin expression through upregulating ETO2.

Reactivating the embryonic ζ-globin gene represents a potential therapeutic approach to ameliorate the severe clinical phenotype of α-thalassemia and sickle cell disease. The transcription factor MYB has been extensively proven to be a master regulator of the γ-globin gene, but its role in the regulation of ζ-globin remains incompletely understood. Here, we report a mechanistic study on the derepression of ζ-globin both and .

The effect of glass container surface silanol density on monoclonal antibody formulation stability after application of mechanical shock.

This study investigates the effect of silanol density on the surface of glass containers on the stability of monoclonal antibody (mAb) formulations subjected to mechanical stress. By calcining Type I glass containers at different temperatures, we altered the concentration of silanols on the glass surface and examined its impact on the stability of protein formulations under mechanical stress. Contact angle measurements and Fourier Transform Infrared (FTIR) spectroscopy indicated that silanol formation influences the hydrophilicity of the surface.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Data-Driven Machine Learning Strategy for Designing Metal-Ion-Doped γ-BiMoO Photocatalysts to Enhance Degradation Performance.

Doped semiconductors are often used to improve photocatalytic efficiency and address the challenges of easy recombination of electron-hole pairs and poor photoluminescence. However, the reproducibility and complexity of experimental studies result in time-consuming and less cost-effective studies, and it is difficult to gain insights into the intrinsic properties of doped photocatalysts to control their performance. Introducing a machine learning approach, we constructed a photocatalytic model of transition-metal- and rare earth metal-ion-doped γ-BiMoO.

Graphene Quantum Dot Sensitized Heterojunctions Induce Tumor-Specific Cuproptosis to Boost Sonodynamic and Chemodynamic Enhanced Cancer Immunotherapy.

Cuproptosis that utilizes copper ionophore to induce programmed cell death holds promise for enhancing the effectiveness of conventional anticancer therapies and triggering efficient adaptive immune responses. However, the non-tumor-specific release of Cu ions can induce cuproptosis and cause irreversible damage to normal tissues. To maximize the therapeutic effects of tumor-specific cuproptosis, this work reports for the first time the regulation of degradation behaviors of Cu-based nanomaterials using graphene quantum dots (GQDs) as a protection layer.

Single-cell atlas comparison across vertebrates reveals auditory cell evolution and mechanisms for hair cell regeneration.

Mammals suffer permanent hearing impairment from the loss of auditory hair cells due to their inability to regenerate. In contrast, lower vertebrates exhibit extraordinary capacity for hair cell regeneration and hearing restoration, but the mechanisms remain unclear. Here we characterize the single-cell atlas of Xenopus laevis inner ear and perform a comprehensive comparison with mouse model.

A prospective, multi-center post-marketing surveillance cohort study to monitor the safety of the recombinant zoster vaccine in Chinese adults ≥50 years of age.

This post-marketing surveillance study evaluated the safety of the adjuvanted recombinant zoster vaccine (RZV) in Chinese adults, given the limited country-specific safety data accumulated since the 2019 licensure of RZV in China for adults ≥ 50 years of age (YOA). This descriptive, prospective cohort study enrolled adults ≥ 50 YOA who voluntarily received RZV per routine clinical practice in six centers in China. The primary outcomes were occurrence, intensity, and causal relationship to vaccination of medically attended adverse events (MAEs) within 30 days post-any dose.

Allelic variation in the promoter of WRKY22 enhances humid adaptation of Arabidopsis thaliana.

Submergence stress tolerance is a complex trait governed by multiple loci. Because of its wide distribution across arid and humid regions, Arabidopsis thaliana offers an opportunity to explore the genetic components and their action mechanisms underlying plant adaptation to submergence stress. In this study, using map-based cloning we identified WRKY22 that activates RAP2.

Acceptance of human papillomavirus vaccine among boys in Asia: A narrative review.

Human papillomavirus (HPV) is a prevalent sexually transmitted infection globally, linked to genital warts and various cancers. The burden of HPV-related diseases in males is rising significantly. We reviewed studies published until September 2024 from databases like PubMed, Embase®, and Web of Science, summarizing HPV vaccination acceptance among boys and parents in Asia and exploring influencing factors.

Effects of tannin-tolerant lactic acid bacteria in combination with tannic acid on the fermentation quality, protease activity and bacterial community of stylo silage.

Background: Proteolysis during ensiling primarily occurs due to undesirable microbial and plant protease activities, which reduce the protein supply to ruminant livestock and cause a series of environmental problems. The objective of this study was to investigate the effects of the tannin-tolerant lactic acid bacterium strain Lactiplantibacillus plantarum 4 (LABLP4) in combination with tannic acid (TA) on protein preservation in stylo (Stylosanthes guianensis) silage. The stylos were either ensiled without additives (control) or treated with LABLP4 (10 colony-forming units per gram of fresh matter), 1% (fresh matter basis) TA, 2% TA, LABLP4 + 1% TA and LABLP4 + 2% TA.

Melamine-Derived Mesoporous Carbon for Efficient and Selective Removal of Trace Hg(II) from Honeysuckle Decoction.

Melamine-derived mesoporous carbon, which was obtained from pyrolysis of modified melamine, was employed for the purpose of eliminating trace amounts of Hg(II) from honeysuckle decoction. The specific surface area of the mesoporous carbons with N-functional (MCN) was 648.372 m·g.

Electrically tunable graded photonic crystal lens based on graphene plasmons.

Controlling the nonlinear relationship between surface plasmon polariton (SPP) mode index and chemical potential of graphene can be used in the field of active transformation optics. Here, we propose an electrically tunable 2D Graded Photonic Crystal (GPC) lens based on graphene SPP platform. Our platform comprises a graphene monolayer integrated into a back-gated structure with nano-patterned gate insulators.

Androgen Receptor Mediates Dopamine Agonist Resistance by Regulating Intracellular Reactive Oxygen Species in Prolactin-Secreting Pituitary Adenoma.

Dopamine agonists (DAs) are the first-line treatment for patients with prolactin-secreting pituitary adenoma (PRL adenoma). However, a subset of individuals exhibits poor responses, known as DA resistance. Previous studies have reported that DA resistance is more prevalent in male patients.