Multi-omics profiling reveals elevated CO-enhanced tolerance of Trifolium repens L. to lead stress through environment-plant-microbiome interactions.

The increasing atmospheric CO resulting from human activities over the past two centuries, which is projected to persist, has significant implications for plant physiology. However, our predictive understanding of how elevated CO (eCO) modifies plant tolerance to metal stress remains limited. In this study, we collected roots and rhizosphere soils from Trifolium repens L.

Cabozantinib-encapsulated and maytansine-conjugated high-density lipoprotein for immunotherapy in colorectal cancer.

Advanced colorectal cancer (CRC) responds poorly to current adjuvant therapies, partially due to its immunosuppressive intestinal microenvironment. We found that myeloid-derived suppressor cells (MDSCs) were enriched in orthotopic tumors due to treatment-induced succinate release, which activated tuft cells and upregulated interleukin 25 (IL-25) and interleukin 13 (IL-13). We engineered a cabozantinib (Cabo)-encapsulated and maytansine (DM1)-conjugated synthetic high-density lipoprotein (CD-sHDL) to modulate the tumor microenvironment.

A decade of insight: bibliometric analysis of gut microbiota's role in osteoporosis (2014-2024).

Purpose: Osteoporosis represents a profound challenge to public health, underscoring the critical need to dissect its complex etiology and identify viable targets for intervention. Within this context, the gut microbiota has emerged as a focal point of research due to its profound influence on bone metabolism. Despite this growing interest, the literature has yet to see a bibliometric study addressing the gut microbiota's contribution to both the development and management of osteoporosis.

Pullulan-Based Spray-Dried Mucoadhesive Microparticles for Sustained Oromucosal Drug Delivery.

Mucoadhesive microparticles for oromucosal drug delivery offer several advantages, including intimate contact with the mucosa, delivery to less accessible regions, extended residence time, sustained drug release, reduced irritation, and improved patient compliance. In this study, pullulan was used to prepare mucoadhesive spray-dried microparticles for delivering benzydamine hydrochloride (BZH) to oral mucosa. The BZH-pullulan spray-dried microparticles had a mean size of <25 μm with an angle of repose values between 25.

Adenosine-modulating synthetic high-density lipoprotein for chemoimmunotherapy of triple-negative breast cancer.

Adenosine (ADO) is a common chemotherapy-associated immune checkpoint that hinders anti-tumor immunity-mediated efficacy of chemotherapy. Herein, we created a synthetic high-density lipoprotein (sHDL) by co-assembly of a doxorubicin (DOX)-apolipoprotein A1 mimetic peptide conjugate, PSB-603 (an A2BR inhibitor), phospholipid, and cholesterol oleate with a microfluidic-based method. The obtained DP-sHDL showed a self-promoted drug delivery to cancer cells via remodeling tumor microenvironment.

Hounsfield units on abdominal computed tomography: a new tool for predicting osteoporosis.

Background: Osteoporosis can cause bone fractures and disability, but early diagnosis faces challenges. Our proposed diagnostic indicators offer a new approach for early detection, which benefits early identification.

Purpose: To determine the most appropriate threshold for predicting osteoporosis in patients with each section of vertebral body.

Tunable non-volatile memories based on 2D InSe/-BN/GaSe heterostructures towards potential multifunctionality.

Floating-gate memories based on two-dimensional van der Waal (2D vdW) heterostructures play an important role in the development of next-generation information technology. The diversity of 2D vdW materials and their heterostructures provides flexibility in the design of novel storage architectures. However, 2D InSe/-BN/GaSe heterostructures are rarely reported in the field of tunable non-volatile memories, probably due to the quality limitation of materials and complex interfaces from stackings.

Application of visual communication in digital animation advertising design using convolutional neural networks and big data.

In the age of big data, visual communication has emerged as a critical means of engaging with customers. Among multiple modes of visual communication, digital animation advertising is an exceptionally potent tool. Advertisers can create lively and compelling ads by harnessing the power of digital animation technology.

Design of public cultural sign based on Faster-R-CNN and its application in urban visual communication.

People are increasingly enthusiastic about pursuing spiritual life as economic and social development continues. Consequently, public cultural content has emerged as a pivotal instrument for promoting international soft power across diverse nations and regions. In today's era of advanced artificial intelligence, cultural sign design optimization has become achievable through its deployment.

Efficient Strategy for U(VI) Photoreduction: Simultaneous Construction of U(VI) Confinement Sites and Water Oxidation Sites.

Reduction of hexavalent uranium [U(VI)] by the photocatalytic method opens up a novel way to promote the selectivity, kinetics, and capacity during uranium removal, where organic molecules act as the sacrificial agents. However, the addition of sacrificial agents can cause a secondary environmental pollution and increase the cost. Here, a UiO-66-based photocatalyst (denoted as MnO/NH-UiO-66) simultaneously with efficient U(VI) confinement sites and water oxidation sites was successfully developed, achieving excellent U(VI) removal without sacrificial agents.

DeepLPI: a novel deep learning-based model for protein-ligand interaction prediction for drug repurposing.

The substantial cost of new drug research and development has consistently posed a huge burden for both pharmaceutical companies and patients. In order to lower the expenditure and development failure rate, repurposing existing and approved drugs by identifying interactions between drug molecules and target proteins based on computational methods have gained growing attention. Here, we propose the DeepLPI, a novel deep learning-based model that mainly consists of ResNet-based 1-dimensional convolutional neural network (1D CNN) and bi-directional long short term memory network (biLSTM), to establish an end-to-end framework for protein-ligand interaction prediction.

Material removal and surface damage in high-speed grinding of enamel.

Although high-speed grinding of the enamel surface is often required in restorative dentistry, the knowledge of grinding mechanics, material removal, and fracture damage mechanism related to this process is still relatively limited; therefore, it is important to perform relevant scientific and theoretical research. As per the occlusal surface and the buccal/lingual surface of the teeth, the experimental scheme of high-speed grinding of the enamel surface using a diamond grinding bur was designed, and the grinding force, force ratio, grinding temperature, chips, surface morphology, surface damage, and other important characteristics were tested and analyzed. Furthermore, the grinding geometry model, grinding mechanics, material fracture, and removal mechanism associated with the high-speed grinding of an enamel surface were considered.

Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity.

The efficacy of radiotherapy is greatly challenged by intense hypoxia, intricate stroma and suppressive immune microenvironments in tumors. Herein, we rationally designed a microvesicle-inspired oxygen-delivering polyfluorocarbon nanosystem loading DiIC18(5) and halofuginone (M-FDH) with prominent capacity of improving tumor oxygenation and intratumor distribution, synergizing radiation to disrupt tumor stroma and boost antitumor immunity for combinational cancer therapy. M-FDH produced a 10.

Lightweight Anonymous Authentication and Key Agreement Protocol Based on CoAP of Internet of Things.

To solve the problem regarding the lack of a lightweight and secure authentication and key agreement protocol in the Constrained Application Protocol of the Internet of Things environment, we explore the security flaws and applicability problems in the current related research. Then, we propose a new lightweight authentication and key agreement protocol based on the CoAP framework. The scheme adopts shared secret and elliptic curve public key technology, which ensures the anonymity of the communicators and provides strong security and anti-attack capacity.

Niche and range dynamics of Tasmanian blue gum ( Labill.), a globally cultivated invasive tree.

The ecological niche concept has provided insights into various areas in ecology and biogeography. Although there remains much controversy regarding whether species niches are conserved across space and time, many recent studies have suggested that invasive species conserve their climatic niche between native and introduced ranges; however, whether the climatic niche of cultivated invasive species, whose niches are strongly affected by human activities, are conserved between native and introduced ranges remains unclear. Additionally, the range dynamics of invasive species in their native and introduced regions have not been extensively studied.

Lenvatinib- and vadimezan-loaded synthetic high-density lipoprotein for combinational immunochemotherapy of metastatic triple-negative breast cancer.

Metastatic triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer. Combination of systemic chemotherapy and immune checkpoint blockade is effective but of limited benefit due to insufficient intratumoral infiltration of cytotoxic T lymphocytes (CTLs) and the accumulation of immunosuppressive cells. Herein, we designed a lenvatinib- and vadimezan-loaded synthetic high-density lipoprotein (LV-sHDL) for combinational immunochemotherapy of metastatic TNBC.

Cultivation has selected for a wider niche and large range shifts in maize.

Background: Maize ( L.) is a staple crop cultivated on a global scale. However, its ability to feed the rapidly growing human population may be impaired by climate change, especially if it has low climatic niche and range lability.

Gut Microbiome Differences in Rescued Common Kestrels () Before and After Captivity.

Gut microbes significantly impact animal health, yet research on the gut microbiota of most birds, especially raptors, is lacking. This study investigated the effects of dietary and environmental changes on the composition and abundance of gut microbiota in 17 rescued common kestrels () through 16S rRNA gene high-throughput sequencing of microorganisms in the feces of the birds. Firmicutes (relative abundance, 43.

Clinical Study on the Use of Acupuncture for the Treatment of Female Sexual Dysfunction: A Pilot Study.

Introduction: Female sexual dysfunction (FSD) seriously affects the quality of life of women. However, most women do not have access to effective treatment.

Aim: This study aimed to determine the feasibility and effectiveness of the use of acupuncture in FSD treatment based on existing clear acupuncture protocol and experience-supported face-to-face therapy.

Clinical Characteristics and Risk Factors for Pulmonary Infection in Emergency ICU Patients.

Background: Pulmonary infection in the emergency ICUs increases patient morbidity, hospital stay, treatment costs, and the risk of related adverse events.

Methods: This study included 695 patients admitted to our emergency ICU between December 2019 and March 2021. Medical records of emergency ICU patients were reviewed to collect their clinical data, including antibiotic use, history of tracheostomy, history of mechanical ventilation, presence or absence of underlying disease, history of smoking, alcohol consumption, age, gender, and history of shock.

M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors.

Cancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell-cell communication in tumors, we herein designed M2 macrophage microvesicle-inspired nanovehicle of cabazitaxel (M-CFN) to promote accessibility to cancer cells and CSCs in tumors. In the 4T1 tumor model, M-CFN flexibly permeated the tumor mass, accessed cancer cells and CD90-positive cells, and significantly promoted their entry into CSC fractions in tumors.