Publications by authors named "Xiang Gao"

Lipid metabolism disorder is a critical feature of Crohn's disease (CD). Phosphatidylinositol (PI) and its derivative, phosphatidylinositol bisphosphate (PIP2), are associated with CD. The mechanisms underlying such association remain unknown.

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Importance: It remains unclear how socioeconomic status (SES) is related to the association between diet and health, as well as the role of behavioral factors, in explaining socioeconomic disparities in health outcomes.

Objective: To investigate the associations of neighborhood and individual SES factors, as well as behavioral factors, particularly dietary pattern, with health outcomes.

Design, Setting, And Participants: This prospective cohort study included US health professionals without chronic diseases at baseline who were enrolled in the Health Professionals Follow-Up Study (calendar years 1988-2018), the Nurses' Health Study (calendar years 1992-2018), and the Nurses' Health Study II (calendar years 2001-2019).

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Background: Evidence on the potential effects of midday napping on risk of stroke in Chinese populations remains limited.

Objectives: We aimed to prospectively investigate the association between midday napping and risk of subsequent stroke and stroke subtypes in the Kailuan study.

Methods: Midday napping duration was obtained from a self-reported questionnaire.

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For single-molecule studies requiring surface anchoring of biomolecules, poorly passivated surfaces can result in alterations of biomolecule structure and function that lead to artifacts. Here, we present a surface passivation assay for single-molecule studies of chromatin and topoisomerase II. We detail steps for preparing a nucleosome array and hydrophobic nitrocellulose-coated flow cell.

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Background: To date, the effect of tau phosphorylation at different amino acid sites on the conformation and function of tau is still unclear in Alzheimer's disease (AD). Protein fingerprinting, also known as the protein folding shape code (PFSC) method, is a protein structure prediction technique based on protein sequence, which can reveal proteins' most likely spatial conformation.

Objective: To investigate the effect of phosphorylation on tau protein conformation using PFSC technology and further analyze the differences in the effect of phosphorylation on tau aggregation at specific sites.

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Objective: This study aimed to investigate the association of whole body/regional fat mass (FM) with cardiometabolic disease (CMD) trajectory.

Methods: We conducted a prospective analysis using the UK Biobank. The FM index (FMI), a surrogate for whole body FM, and regional FM (i.

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Background: Progress in immunotherapy for pancreatic ductal adenocarcinoma (PDAC) has been slow, yet the relationship between microorganisms and metabolites is crucial to PDAC development. This study compares the biliary microbiota and metabolomic profiles of PDAC patients with those of benign pancreatic disease patients to investigate PDAC pathogenesis and its relationship with immunotherapy.

Methods: A total of 27 patients were recruited, including 15 diagnosed with PDAC and 12 with benign pancreaticobiliary conditions, all of whom underwent surgical treatment.

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In this report, we disclose the design and synthesis of a series of 2-trifluoromethyl-2H- chromene ethers as novel COX-2 inhibitors with low ulcerogenicity. Among them, 6-fluoro-3-(4-methoxyphenyl)-2-(2-(thiophen-3-yl)ethoxy)-2-(trifluoromethyl)-2H-chromene (E25) significantly suppressed LPS-induced release of NO and PGE, expression of COX-2 and iNOS, and activation of NF-κB pathway. The inhibitory effect of E25 on human recombinant COX-2 (IC = 70.

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Drought-induced changes in lakes and wetlands, crucial habitats for migratory waterbirds, can greatly affect their foraging and habitat utilization. These changes lead to a decline in waterbird species richness and may cause shifts in community assembly from phylogenetic and functional trait perspectives. However, a gap remains between ecological mechanistic research about these changes and conservation applications.

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The angular optical trap (AOT) is a powerful technique for measuring the DNA topology and rotational mechanics of fundamental biological processes. Realizing the full potential of the AOT requires rapid torsional control of these processes. However, existing AOT quartz cylinders are limited in their ability to meet the high rotation rate requirement while minimizing laser-induced photodamage.

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Background: At present, there is no effective drug to remove residual stones. Total flavonoids of desmodium styracifolium (TFDS) is an innovative traditional Chinese medicine listed in 2022, which can be used to treat ureteral calculi. This study was to explore the effectiveness and economic value of TFDS in the treatment of residual stones after flexible ureteroscopic lithotripsy (FURL).

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Background: O-GlcNAc transferase (OGT) is responsible for attaching O-linked N-acetylglucosamine (O-GlcNAc) to proteins, regulating diverse cellular processes ranging from transcription and translation to signaling and metabolism. This study focuses on the role and mechanisms of OGT in osteogenesis.

Materials And Methods: We found that OGT is downregulated in osteoporosis by bioinformatics analysis, determined its role in osteogenic differentiation by using OGT inhibitors (or OGA inhibitors) as well as conditional knockout OGT mice in and in , and explored and specific mechanisms by quantitative proteomic analysis and RNA-seq, qRT-PCR, western blotting, immunofluorescence, H&E, ALP, ARS, Masson staining, IHC, micro CT, etc.

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Flower color change, a common phenomenon that is important in pollination ecology, has intrigued scientists for decades. While previous flower color studies have mainly focused on color diversity among different plant species, our focus is on unraveling the mechanism of post-anthesis color change (PACC) and the molecular basis for its presence and absence, respectively, in two closely related species of Lotus, Lotus filicaulis and Lotus japonicus MG20. Metabolomic analysis reveals anthocyanins as the key metabolites responsible for the observed PACC.

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Circular RNAs have been implicated as critical regulators in the initiation and progression of colorectal cancer (CRC). This study was intended to elucidate the functional significance of the circ_0089761/miR-27b-3p/programmed cell death ligand 1 (PD-L1) axis in CRC. Our findings indicated that circ_0089761 expression was significantly elevated in CRC tissues and cell lines.

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Article Synopsis
  • Mammary duct fistula is an abnormal connection between a breast duct and nearby tissue, generally caused by duct wall rupture, leading to inflammation and possible infections.
  • A case involving a patient from Dongzhimen Hospital shows that a modified surgical procedure effectively corrected nipple inversion and eliminated recurrence of the condition.
  • The novel surgical approach has proven effective in preventing future issues, reducing recovery time, and addressing complications, suggesting it may be a viable treatment option for similar cases.
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  • This study investigated the role of GTSE1 in lung adenocarcinoma (LUAD), focusing on its diagnostic and therapeutic potential, as well as its effects on immune response and treatment efficacy.* -
  • Researchers analyzed data from multiple databases and clinical samples, finding that higher GTSE1 levels in LUAD tissues correlated with better diagnostic accuracy and served as a significant prognostic indicator, making it an independent predictor of patient outcomes.* -
  • The findings highlighted that increased GTSE1 expression is linked to immune cell infiltration and sensitivity to certain chemotherapy and targeted treatments, along with its potential involvement in key cellular processes like the cell cycle and protein degradation pathways.*
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  • This study examines how misalignment of circadian rhythms and sleep patterns relates to cardiometabolic diseases (CMDs) like type 2 diabetes, coronary heart disease, and stroke.
  • The research analyzed data from nearly 61,000 participants over about 8 years, finding that both early and late circadian misalignment were linked to higher risks of developing CMDs.
  • The findings suggest that aligning sleep-wake cycles with personal circadian preferences could improve health outcomes, particularly highlighting greater risks in women and younger individuals.
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Polymers with microstructure patterns are crucial to many applications, such as separation, optics, electronics, metamaterials, etc. However, introducing microstructure patterns with diverse morphologies and feature sizes ranging from nanometers to micrometers into large-area polymers remains a significant challenge. Here, we design a material system that enables digital programming microphase separation in a polymer network to generate microstructure patterns.

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  • Ferroptosis plays a significant role in spinal cord injury (SCI), and its suppression is linked to proteins like Ferroptosis suppressor protein 1 (FSP1) and Glutathione peroxidase 4 (GPX4).
  • FSP1 levels decrease during the acute and subacute phases of SCI, impacting both ferroptosis regulation and cellular homeostasis.
  • Idebenone (IDE) is identified as a potent ferroptosis inhibitor, protecting oligodendrocytes and neurons and aiding in myelination and recovery of injured spinal cord tissue, highlighting potential new therapeutic approaches for SCI.
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Alloy-type materials are desirable for high-energy sodium-ion batteries. Different from nanoengineering with pre-reserving void space and confined carbon coatings, microsized particles promise high specific/volumetric capacities, easy manufacturing, and low cost but are prone to rapid capacity loss. Herein, inspired by the process of "root growth in soil", microsized Bi particles (µm-Bi, as "seeds") surrounded by microsized hard carbon particles (µm-HC, as "soil") are ingeniously dispersed through a simple mixing approach.

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Background: The indicators of abdominal obesity have shown to be associated with a high risk of cardiovascular diseases (CVDs), even adjusted for body mass index (BMI). We aimed to investigate the association between neck circumference, waist-to-height ratio (WHtR), Chinese visceral adiposity index (CVAI) and incident heart failure (HF) in Chinese adults.

Methods: The current study included 86,546 participants from two independent cohorts: the Kailuan I study established in 2006 and the Kailuan study II established in 2008.

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In recent years, research on active polysaccharides has progressed significantly, particularly regarding their anticancer and immunomodulatory properties. Among these, clam polysaccharides, a type of marine-derived polysaccharide, exhibit notable biological activities, including both anticancer effects and immune modulation. The aims of this study are to investigate the anticancer and immunomodulatory effects of microwave-extracted clam polysaccharide (MCP) in vitro.

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