Tetrabromobisphenol-A/S and their derivatives in surface particulates from workshop floors of three representative e-waste recycling sites in China.

Surface particulates collected from the workshop floors of three major e-waste recycling sites (Taizhou, Qingyuan, and Guiyu) in China were analyzed for tetrabromobisphenol A/S (TBBPA/S) and their derivatives to investigate the environmental pollution caused by e-waste recycling activities. Mean concentrations of total TBBPA/S analogs in surface particulates were 31,471-116,059 ng/g dry weight (dw). TBBPA, TBBPA-BGE, and TBBPA-BDBPE were the most frequently detected in particulates with average concentration ranges of 17,929-78,406, 5601-15,842, and 5929-21,383 ng/g dw, respectively.

A deep-learning-based genomic status estimating framework for homologous recombination deficiency detection from low-pass whole genome sequencing.

Genome-wide sequencing allows for prediction of clinical treatment responses and outcomes by estimating genomic status. Here, we developed Genomic Status scan (GSscan), a long short-term memory (LSTM)-based deep-learning framework, which utilizes low-pass whole genome sequencing (WGS) data to capture genomic instability-related features. In this study, GSscan directly surveys homologous recombination deficiency (HRD) status independent of other existing biomarkers.

Clinical efficacy and biomarker analysis of neoadjuvant camrelizumab plus chemotherapy for early-stage triple-negative breast cancer: a experimental single-arm phase II clinical trial pilot study.

Background: Triple-negative breast cancer (TNBC) is associated with a dismal prognosis. Immune checkpoint inhibitors have shown promising antitumor activity in neoadjuvant settings. This single-arm, phase II trial aimed to evaluate the efficacy and safety of camrelizumab plus chemotherapy as the neoadjuvant therapy (NAT) in early TNBC.

Integrating policy to achieve a harmonized sustainability model: A multidisciplinary synthesis and conceptual framework.

While the concept of environmental sustainability has steadily grown over the past thirty years, little progress has been made in unifying the efforts of the entities most involved: society, the environment, the economy, and governmental policy. This synthesis integrates across disciplines to outline the need for a harmonized sustainability model to align disparate environmental objectives. Specifically, this study highlights the disconnect between policy and capitalistic economies regarding environmental sustainability.

Constructing anatase TiO/Amorphous NbO heterostructures to enhance photocatalytic degradation of acetaminophen and nitrogen oxide.

TiO nanostructures have been one of the most explored metal oxides photocatalysts to apply for environmental remediation. However, its wide band gap results in the underutilization of sunlight for degradation of pollutants. In order to overcome this handicap, the synthesis of TiO-based composite has brought extraordinary materials.

MIR31HG regulates the proliferation, migration and invasion of breast cancer by regulating the expression of POLDIP2.

Purpose: This study aimed to explore the role of MIR31HG and its molecular mechanism in breast cancer (BC).

Methods: The levels of MIR31HG in BC tissues and cell lines were detected. The correlations of MIR31HG expression level with clinical characteristics and prognosis of patients were analyzed.

Depolarization Characteristics of Different Reflective Interfaces Indicated by Indices of Polarimetric Purity (IPPs).

Compared with the standard depolarization index, indices of polarimetric purity (IPPs) have better performances to describe depolarization characteristics of targets with different roughnesses of interfaces under different incident angles, which allow us a further analysis of the depolarizing properties of samples. Here, we use IPPs obtained from different reflective interfaces as a criterion of depolarization property to characterize and classify targets covered by organic paint layers with different roughness. We select point-light source as radiation source with wavelength as 632.

An Adaptive Multi-Channel Cooperative Data Transmission Scheduling in VANETs.

The Internet of Vehicle (IoV) technology is one of the most important technologies of modern intelligent transportation. The data transmission scheduling method is a research hotspot in the technology of IoV. It is a challenge to ensure the stability of data transmission due to fast network topology changes, high data transmission delays, and some other reasons.

Can adoption of pollution prevention techniques reduce pollution substitution?

Pollution prevention (P2) has become an integral part of the U.S. environmental policy that emphasizes the benefits of preventing pollution generation at the source over treatment or recycling after the generation of wastes.

Full-Duplex Multi-Hop Wireless Networks Optimization with Successive Interference Cancellation.

In wireless network communication, in-band full-duplex technique is a useful and important technique that can enlarge the whole throughput of the wireless networks. However, its use needs harsh environment. The successive interference cancellation can make several transmitters' data be received simultaneously by the receiver, and can make the in-band full-duplex technique be used easily in reality.

Quantification of DNA by a Thermal-Durable Biosensor Modified with Conductive Poly(3,4-ethylenedioxythiophene).

The general clinical procedure for viral DNA detection or gene mutation diagnosis following polymerase chain reaction (PCR) often involves gel electrophoresis and DNA sequencing, which is usually time-consuming. In this study, we have proposed a facile strategy to construct a DNA biosensor, in which the platinum electrode was modified with a dual-film of electrochemically synthesized poly(3,4-ethylenedioxythiophene) (PEDOT) resulting in immobilized gold nanoparticles, with the gold nanoparticles easily immobilized in a uniform distribution. The DNA probe labeled with a SH group was then assembled to the fabricated electrode and employed to capture the target DNA based on the complementary sequence.

Molecular Assembly of a Durable HRP-AuNPs/PEDOT:BSA/Pt Biosensor with Detailed Characterizations.

In this study, we provided the detailed characterizations of our recent HRP-AuNPs/PEDOT:BSA/Pt biosensor, constructed through a simple fabrication procedure with improved stability and good sensitivity. Raman and Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy not only confirmed the synthesis of conductive PEDOT where BSA was the template for the polymerization, but also provided further insights into the stable immobilization of AuNP on the PEDOT:BSA film. Scanning electron microscopy revealed that the attachment of AuNPs were stable under a high salt environment.

Polycyclic aromatic hydrocarbons in soils from the Central-Himalaya region: Distribution, sources, and risks to humans and wildlife.

The Central Himalayas are not only a natural boundary between China and Nepal but also a natural barrier for transport of air masses from South Asia. In this study, 99 samples of surface soil were collected from five regions of Nepal on the southern side of the Central Himalayas, and 65 samples of surface soil were obtained from the northern side on the edge of the Tibetan Plateau, China (TPC). Concentrations of polycyclic aromatic hydrocarbons (PAHs) in soils were measured to determine their distribution, potential for accumulation, and sources, as well as risks to humans and the environment.

Identification of sources of polycyclic aromatic hydrocarbons based on concentrations in soils from two sides of the Himalayas between China and Nepal.

To understand distribution and sources of polycyclic aromatic hydrocarbons (PAHs) in the Himalayas, 77 soil samples were collected from the northern side of the Himalayas, China (NSHC), and the southern side of the Himalayas, Nepal (SSHN), based on altitude, land use and possible trans-boundary transport of PAHs driven by wind from Nepal to the Tibetan Plateau, China. Soils from the SSHN had mean PAH concentration greater than those from the NSHC. Greater concentrations of PAHs in soils were mainly distributed near main roads and agricultural and urban areas.

Comparison of single-agent chemotherapy and targeted therapy to first-line treatment in patients aged 80 years and older with advanced non-small-cell lung cancer.

Purpose: The aim of this study was to compare single-agent chemotherapy with targeted therapy in initial treatment and to explore a better choice of treatment for patients aged 80 years and older with advanced non-small-cell lung cancer (NSCLC).

Patients And Methods: A retrospective chart review was conducted for 136 patients aged 80 years and older who were cytopathologically diagnosed and staged as advanced (stage IIIB or IV) NSCLC. The patient population was divided into two treatment groups: 78 patients were allocated to the chemotherapy group (group A, pemetrexed or gemcitabine or docetaxel as a single agent), and 60 patients were allocated to another group and received epidermal growth factor-receptor tyrosine-kinase inhibitors (group B, erlotinib or gefitinib as a single agent).

[Spatial distribution of Se in soils from different land use types and its influencing factors within the Yanghe Watershed, China].

Based on different land use types, altitudes, soil and vegetation types etc, 171 representative topsoils (0-10 cm) were collected within the Yanghe watershed, China for determining the total concentrations, spatial distribution and influencing factors of selenium (Se). The results showed that the total selenium concentrations in soils within the watershed ranged from 0.02 to 3.

Validation of the Memorial Sloan Kettering Cancer Center nomogram for predicting non-sentinel lymph node metastasis in sentinel lymph node-positive breast-cancer patients.

Background: The main purpose of the study reported here was to validate the clinical value of the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram that predicts non-sentinel lymph node (SLN) metastasis in SLN-positive patients with breast cancer.

Methods: Data on 1,576 patients who received sentinel lymph node biopsy (SLNB) at the Shandong Cancer Hospital from December 2001 to March 2014 were collected in this study, and data on 509 patients with positive SLN were analyzed to evaluate the risk factors for non-SLN metastasis. The MSKCC nomogram was used to estimate the probability of non-SLN metastasis and was compared with actual probability after grouping into deciles.

Clinical significance of UGT1A1 gene polymorphisms on irinotecan-based regimens as the treatment in metastatic colorectal cancer.

Purpose: The primary aim of this research was to investigate the association between uridine diphosphate glucuronosyltransferase (UGT)1A1 gene polymorphisms and the toxicities of irinotecan-based regimens in Chinese patients with metastatic colorectal cancer.

Methods: The study analyzed the distribution of UGT1A1*28/*6 gene polymorphisms by polymerase chain reaction amplification and pyrosequencing. The adverse reactions and tumor response were evaluated according to National Cancer Institute Common Toxicity Criteria for Adverse Events, Version 3.