Sex-dimorphic tumor growth is regulated by tumor microenvironmental and systemic signals.

Tumor growth and progression involve coordinated regulation by internal, microenvironmental, and systemic signals and often display conspicuous sexual dimorphism. The mechanisms governing the integration and coordination of these signals, along with their sex-based differences, remain largely unknown. Using a tumor model originating from nonreproductive tissue, we show that female-biased tumor growth involves multifaceted communications among tumor cells, hemocytes, and neuroendocrine insulin-producing cells (IPCs).

Spatiotemporal dynamics and tidal transport of microplastics in the tropical waters of the Gulf of Thailand.

Microplastics (MPs) contamination was investigated along a freshwater-seawater continuum from Chumphon River to the Gulf of Thailand. The vertical distribution in the water column and contamination in green mussels were also studied. MPs were detected in all water samples and sediment samples.

Aptamer sgc8-Modified PAMAM Nanoparticles for Targeted siRNA Delivery to Inhibit BCL11B in T-Cell Acute Lymphoblastic Leukemia.

Introduction: T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematological disease with limited targeted therapy options. Overexpression of B-cell lymphoma/leukemia 11B is frequently observed in T-ALL and contributes to leukemogenesis. Knockdown of BCL11B inhibits T-ALL cell proliferation and induces apoptosis, making it a potential therapeutic target.

Involvement of UDP-glycosyltransferase of Kalanchoe pinnata (Lam.) Pers in quercitrin biosynthesis and consequent antioxidant defense.

Plants in the Crassulaceae family are rich in flavonoids, which may contribute to their high antioxidant activity and strong tolerance to abiotic stresses. Kalanchoe spp. are known to have high antioxidant activity, but the main components responsible for this activity and the mechanisms that control antioxidant accumulation in these plants are unknown.

Modeling of Static Stress Identification Using Electromechanical Impedance of Embedded Piezoelectric Plate.

Working stress is an important indicator reflecting the health status of structures. Passive-monitoring technology using the piezoelectric effect can effectively monitor the dynamic stress of structures. However, under static loads, the charge generated by the piezoelectric devices can only be preserved when the external circuit impedance is infinitely large, which means passive-monitoring techniques are unable to monitor static and quasi-static stress caused by slow-changing actions.

Source apportionment and emission projections of heavy metals from traffic sources in India: Insights from elemental and Pb isotopic compositions.

The study investigates the sources of metals in urban road dusts using elemental concentration and Pb isotopic ratios. The elemental concentrations are also utilized to determine the present heavy metal emissions as well as projected emissions till 2045. Bayesian mixing model for source apportionment highlights the significant contributions of both exhaust and non-exhaust sources to the metal-enriched urban road dusts, with each contributing approximately 40 %.

Impact of the novel chlorinated polyfluorinated ether sulfonate, F-53B, on gill structure and reproductive toxicity in zebrafish.

6:2 Chlorinated polyfluorinated ether sulfonate, commonly known as F-53B, is widely used as a mist suppressant in various industries and is frequently detected in the environment. Despite its prevalent presence, the adverse effects of F-53B are not well understood and require future investigation. This study utilized zebrafish embryos and adults to examine the toxic effects of F-53B.

Performance Correction and Parameters Identification Considering Non-Uniform Electric Field in Cantilevered Piezoelectric Energy Harvesters.

In the current electromechanical model of cantilevered piezoelectric energy harvesters, the assumption of uniform electric field strength within the piezoelectric layer is commonly made. This uniform electric field assumption seems reasonable since the piezoelectric layer looks like a parallel-plate capacitor. However, for a piezoelectric bender, the strain distribution along the thickness direction is not uniform, which means the internal electric field generated by the spontaneous polarization cannot be uniform.

Ultrathin aerogel-structured micro/nanofiber metafabric via dual air-gelation synthesis for self-sustainable heating.

Incorporating passive heating structures into personal thermal management technologies could effectively mitigate the escalating energy crisis. However, current passive heating materials struggle to balance thickness and insulating capability, resulting in compromised comfort, space efficiency, and limited thermoregulatory performance. Here, a dual air-gelation strategy, is developed to directly synthesize ultrathin and self-sustainable heating metafabric with 3D dual-network structure during electrospinning.

Biodegradable Polyurethane Derived from Hydroxylated Polylactide with Superior Mechanical Properties.

Developing biodegradable polyurethane (PU) materials as an alternative to non-degradable petroleum-based PU is a crucial and challenging task. This study utilized lactide as the starting material to synthesize polylactide polyols (PLA-OH). PLA-based polyurethanes (PLA-PUs) were successfully synthesized by introducing PLA-OH into the PU molecular chain.

MiR-214_L-1R+4 regulate gossypol-induced immune response through MyD88-dependent signaling pathway in Cyprinus carpio.

MicroRNAs (miRNAs) have been demonstrated to act as crucial modulators with considerable impacts on the immune system. Cottonseed meal is often used as a protein source in aqua feed, cottonseed meal contains gossypol, which is harmful to animals. However, there is a lack of research on the role of miRNAs in fish exposed to gossypol stress.

Breathable Dual-Mode Leather-Like Nanotextile for Efficient Daytime Radiative Cooling and Heating.

Incorporating passive radiative cooling and heating into personal thermal management has attracted tremendous attention. However, most current thermal management materials are usually monofunctional with a narrow temperature regulation range, and lack breathability, softness, and stretchability, resulting in a poor wearer experience and limited application scenarios. Herein, a breathable dual-mode leather-like nanotextile (LNT) with asymmetrical wrinkle photonic microstructures and Janus wettability for highly efficient personal thermal management is developed via a one-step electrospinning technique.

Topoisomerase I is an evolutionarily conserved key regulator for satellite DNA transcription.

RNA Polymerase (RNAP) II transcription on non-coding repetitive satellite DNAs plays an important role in chromosome segregation, but a little is known about the regulation of satellite transcription. We here show that Topoisomerase I (TopI), not TopII, promotes the transcription of α-satellite DNAs, the main type of satellite DNAs on human centromeres. Mechanistically, TopI localizes to centromeres, binds RNAP II and facilitates RNAP II elongation.

First record of plastiglomerates, pyroplastics and plasticrusts along the beaches of Tamilnadu, Southeast coast of India.

Plastic litter affects coastal and marine ecosystems globally. This study represents the first record of pyroplastics and plasticrust in the beaches of Tamil Nadu, India. All samples were FTIR spectroscopically examined to confirm the polymer composition of the suspected plastics.

Late Holocene relative sea-level records from coral microatolls in Singapore.

Late Holocene relative sea-level (RSL) data are important to understand the drivers of RSL change, but there is a lack of precise RSL records from the Sunda Shelf. Here, we produced a Late Holocene RSL reconstruction from coral microatolls in Singapore, demonstrating for the first time the utility of Diploastrea heliopora microatolls as sea-level indicators. We produced 12 sea-level index points and three marine limiting data with a precision of < ± 0.

BET Inhibitor JQ1 Selectively Reduce Tregs by Upregulating STAT3 and Suppressing PD-1 Expression in Patients with Multiple Myeloma.

Multiple myeloma (MM) stands as a prevalent hematological malignancy, primarily incurable, originating from plasma cell clones. MM's progression encompasses genetic abnormalities and disruptions in the bone marrow microenvironment, leading to tumor proliferation, immune dysfunction, and compromised treatment outcomes. Emerging evidence highlights the critical role of regulatory T cells (Tregs) in MM progression, suggesting that targeting Tregs could enhance immune functionality and treatment efficacy.

Integrin subunit alpha 5 maintains mitochondrial function in ox-LDL-induced cardiac microvascular endothelial cells via activating the PI3K/AKT signaling pathway.

Cardiac microvascular endothelial cells (CMECs) assume a pivotal role in the regulation of blood flow, and their impairment precipitates a spectrum of pathological transformations. Our previous study unveiled a notable mitigation of CMECs dysfunction through the intervention of integrin subunit alpha 5 (ITGA5), a member of the integrin protein family. This study delves into the effect of ITGA5 on the mitochondrial function in CMECs and reveals the regulation pathway.

Superhydrophobic, Highly Conductive, and Trilayered Fabric with Connected Carbon Nanotubes for Energy-Efficient Electrical Heating.

Current electrically heated fabrics provide heat in cold climates, suffer from abundant wasted radiant heat energy to the external environment, and are prone to damage by water. Thus, constructing energy-efficient and superhydrophobic conductive fabrics is in high demand. Therefore, we propose an effective and facile methodology to prepare a superhydrophobic, highly conductive, and trilayered fabric with a connected carbon nanotube (CNT) layer and a titanium dioxide (TiO) nanoparticle heat-reflecting layer.

Entrapment of atmospheric particle bound heavy metals by ferns as evidenced by lead (Pb) isotope and MixSIAR: Implications for improving air quality.

Plant metal uptake can occur through both soil-root and atmospheric transfer from leaves. The latter holds potential implications for development of biofiltration systems. To explore this potential, it is crucial to understand entrapment capacity and metal sources within plants.