Publications by authors named "Xianfei Qin"
Objective: To study the predictive value of systemic immune index (SII) and systemic inflammatory response index (SIRI) in the prognosis of patients with nasopharyngeal carcinoma.
Methods: Two researchers independently searched PubMed, Cochrane, Embase, and Web of Science databases (until March 18, 2022) for all studies on SII, SIRI, and prognosis in patients with nasopharyngeal carcinoma. Quality assessment of included studies was assessed using the Newcastle-Ottawa Scale (NOS).
Article Synopsis
- Imiquimod (Imiq) enhances contact hypersensitivity (CHS) in mice by activating immune responses, particularly through stimulating dendritic cells and influencing mast cell behavior.
- The application of Imiq led to increased inflammation and a higher proliferation of immune cells in response to a specific allergen, suggesting a stronger immune reaction.
- While Imiq alone did not cause mast cell degranulation, when combined with the allergen, it significantly did so, and targeting histamine release may help reduce allergic reactions.
Imiquimod enhances the potency of an exogenous BM-DC based vaccine against mouse melanoma.
Int Immunopharmacol
November 2018
Dendritic cell (DC) vaccine is a potent immunotherapeutic approach for cancer treatment, but the clinical efficacy needs to be improved. In this study, we evaluated the combinational effect of Toll-like receptor 7 (TLR7) agonist Imiquimod and BM-DC vaccine against mouse melanoma and explored the potential mechanisms. We found that topical application of Imiquimod cream caused skin inflammation and enhanced exogenous BM-DC homing to draining lymph nodes.
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