Study on the efficient electrocatalytic depolymerization of α-O-4 bond in lignin assisted by simple electrolyte.

Lignin is anticipated to serve as a replacement for dwindling fossil fuel resources owing to its abundant sources and renewable nature. The electrochemical oxidation technique for depolymerizing lignin has garnered significant interest for its environmentally friendly and mild operating conditions. Nevertheless, the current utilization of auxiliary electrolytes, predominantly organic bases, ionic liquids, and other specialized substances, poses a constraint on the widespread adoption of this approach.

High-performance electrochemical sensing platform based on sodium alginate-derived 3D hierarchically porous carbon for simultaneous determination of dihydroxybenzene isomers.

Three-dimensional hierarchically porous carbon (denoted as SA-900) with a microporous, mesoporous and macroporous structure was facilely fabricated via direct carbonization of sodium alginate. SA-900 was fully characterized by N adsorption-desorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction and Raman spectroscopy to confirm its structure. SA-900 was coated onto a glassy carbon electrode surface to construct an ultrasensitive electrochemical sensing platform (SA-900/GCE).

Synthesis, growth mechanism and photocatalytic H evolution of CdS/CuS composite hydrothermal method.

In recent years, visible light-driven photocatalysts used for confronting energy shortages and environmental pollution have drawn much attention. CdS is regarded as an excellent photoelectric semiconductor for photocatalysis, but photocorrosion and low photocatalytic activity limit its practical application. In order to improve the photocatalytic performance of CdS, we synthesized a II-type CdS/CuS composite a hydrothermal method in one step.

Glucose-conjugated platinum(IV) complexes as tumor-targeting agents: design, synthesis and biological evaluation.

A new series of glucose-conjugated Pt(IV) complexes that target tumor-specific glucose transporters (GLUTs) was designed, synthesized, and evaluated for their anticancer activities. All six compounds, namely, A1-A6, exhibited increased cytotoxicity that were almost six fold higher than that of oxaliplatin to MCF-7 cells. These Pt(IV) complexes can be reduced to release Pt(II) complexes and cause the death of tumor cells.

Glycosylated Platinum(IV) Complexes as Substrates for Glucose Transporters (GLUTs) and Organic Cation Transporters (OCTs) Exhibited Cancer Targeting and Human Serum Albumin Binding Properties for Drug Delivery.

Glycosylated platinum(IV) complexes were synthesized as substrates for GLUTs and OCTs for the first time, and the cytotoxicity and detailed mechanism were determined in vitro and in vivo. Galactoside Pt(IV), glucoside Pt(IV), and mannoside Pt(IV) were highly cytotoxic and showed specific cancer-targeting properties in vitro and in vivo. Glycosylated platinum(IV) complexes 5, 6, 7, and 8 (IC 0.

Mono-functionalized glycosylated platinum(IV) complexes possessed both pH and redox dual-responsive properties: Exhibited enhanced safety and preferentially accumulated in cancer cells in vitro and in vivo.

A serious of carbohydrate-conjugated platinum(IV) complexes in the form Pt(L2)(A2)(OH)R based on the clinical drug cisplatin and oxaliplatin were designed, synthesized and evaluated as antitumor agents in vitro and in vivo. The conjugates possessing both pH and redox dual-responsive properties exhibited more potent cytotoxicity in seven different human cancer cell lines and lower toxicity to the normal 3T3 cells than cisplatin, oxaliplatin and even the reported bis-functionalized glycosylated platinum(IV) complexes indicating the enhanced safety of the sugar conjugates. Cellular drug uptake and DNA platination were also superior to cisplatin, oxaliplatin and the reported bis-functionalized ones.

Glycosylated platinum(iv) prodrugs demonstrated significant therapeutic efficacy in cancer cells and minimized side-effects.

Conjugates (A1-A5) of the Pt(iv) derivative (A6) with amino groups from peracetyl glucose, rhamnose and mannose with a propyl amino or ethyl amino linker at the reducing end were synthesized and exhibited significant therapeutic efficacy in tumour cells, especially for prostate cancer (PCa). The antitumor activities are greatly affected by glycosyl groups. Cytotoxic experiments in vitro indicated that the antitumor activities were increased by 5-fold when its Pt(iv) derivative was conjugated to S18 (IC50 = 4.

Synthesis and biological evaluations of a series of thaxtomin analogues.

Thaxtomins are a unique family of phytotoxins with unique 4-nitroindole and diketopiperazine fragments possessing potential herbicidal activities. This work presents the total synthesis of natural product thaxtomin C and its analogues. The extensive structure-activity relationship study screens four effective compounds, including thaxtomin A and thaxtomin C.