Publications by authors named "Xianan Mo"

Article Synopsis
  • - Rotator cuff tendinopathy is a widespread and costly musculoskeletal disorder, with stem cell therapy showing promise for healing in advanced cases, although it's not yet widely approved for use.
  • - Clinical trials suggest stem cell therapy could be effective for treating this condition, but significant challenges remain, including determining the best stem cell sources and dosages.
  • - The article discusses strategies for standardizing stem cell populations and selecting appropriate patients, aiming to enhance the clinical application of this innovative treatment.
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Background: Tendinopathy is a common motor system disease that leads to pain and reduced function. Despite its prevalence, our mechanistic understanding is incomplete, leading to limited efficacy of treatment options. Animal models contribute significantly to our understanding of tendinopathy and some therapeutic options.

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Engineering approaches for growth factor delivery have been considerably advanced for tissue regeneration, yet most of them fail to provide a complex combination of signals emulating a natural healing cascade, which substantially limits their clinical successes. Herein, we aimed to emulate the natural bone healing cascades by coupling the processes of angiogenesis and osteogenesis with a hybrid dual growth factor delivery system to achieve vascularized bone formation. Basic fibroblast growth factor (bFGF) was loaded into methacrylate gelatin (GelMA) to mimic angiogenic signalling during the inflammation and soft callus phases of the bone healing process, while bone morphogenetic protein-2 (BMP-2) was bound onto mineral coated microparticles (MCM) to mimics osteogenic signalling in the hard callus and bone remodelling phases.

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