The role of Hrd1 in ultraviolet (UV) radiation induced photoaging.

The purpose of the present study was to evaluate the role of Hrd1 in the ultraviolet (UV) radiation induced photoaging and explore its potential mechanism. The nude mice were exposed to the UVA/UVB irradiation for 10 weeks. The animals were subcutaneously injected with AAV5-NC, Hrd1-shRNA-AAV5, or Hrd1-overexpression-AAV5.

ATRA protects skin fibroblasts against UV‑induced oxidative damage through inhibition of E3 ligase Hrd1.

All‑trans retinoic acid (ATRA) can protect fibroblasts against ultraviolet (UV)‑induced oxidative damage, however, its underlying molecular mechanism is still unclear. The present study aimed to investigate the role of 3‑hydroxy‑3‑methylglutaryl reductase degradation (Hrd1) in the protective effect of ATRA on human skin fibroblasts exposed to UV. The expression of Hrd1 in human or mice skin was assessed by immunohistochemistry (IHC) staining and western blot analysis.

A case report of toxic epidermal necrolysis associated with AZD-9291.

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are a strain of small molecule inhibitors mainly used to treat the metastatic non-small cell lung cancer. Their predominant adverse effect is skin toxicity, usually manifested as acneiform rash, skin fissure, xerosis, and paronychia. Severe epidermal necrosis and exfoliation rarely occur.