The Use of Gut Organoids: To Study the Physiology and Disease of the Gut Microbiota.

The intestinal flora has attracted much attention in recent years. An imbalance in the intestinal flora can cause not only intestinal diseases but also cause a variety of parenteral diseases, such as endocrine diseases, nervous system diseases and cardiovascular diseases. Research on the mechanism of disease is likely to be hampered by sample accessibility, ethical issues, and differences between cellular animal and physiological studies.

Mast cells: key players in digestive system tumors and their interactions with immune cells.

Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health and in the pathophysiology of various illnesses, including allergies, cardiovascular diseases and autoimmune diseases. Recent studies in tumor-related research have demonstrated that mast cells exert a substantial influence on tumor cell behavior and the tumor microenvironment, exhibiting both pro- and anti-tumor effects.

Ion channels and transporters regulate nutrient absorption in health and disease.

Ion channels and transporters are ubiquitously expressed on cell membrane, which involve in a plethora of physiological process such as contraction, neurotransmission, secretion and so on. Ion channels and transporters is of great importance to maintaining membrane potential homeostasis, which is essential to absorption of nutrients in gastrointestinal tract. Most of nutrients are electrogenic and require ion channels and transporters to absorb.

Function of TRP channels in monocytes/macrophages.

The transient receptor potential channel (TRP channel) family is a kind of non- specific cation channel widely distributed in various tissues and organs of the human body, including the respiratory system, cardiovascular system, immune system, etc. It has been reported that various TRP channels are expressed in mammalian macrophages. TRP channels may be involved in various signaling pathways in the development of various systemic diseases through changes in intracellular concentrations of cations such as calcium and magnesium.

Growing in Adversity: A Narrative Study of Resilience Generation in Chinese Families of Children with ASD.

Referring to Walsh's theoretical framework of family resilience while taking into account China's own cultural and institutional context, this study discussed the process of resilience generation in Chinese families of children with ASD. A qualitative approach was taken, using narrative research on 10 Chinese families of children with ASD. Category-content analysis of the data suggests that the generation of resilience in Chinese families of children with ASD is influenced by four factors: (A) cultivating positive family beliefs; (B) adjustment of the family's organizational pattern; (C) extending external resources positively; and (D) optimizing family communication.

Interleukin-4 signalling pathway underlies the anxiolytic effect induced by 3-deoxyadenosine.

Rationale: Converging evidence suggests that neuroimmunity plays an important role in the pathophysiology of anxiety. Interleukin (IL)-4 is a key cytokine regulating neuroimmune functions in the central nervous system. More efficient anxiolytics with neuro-immune mechanisms are urgently needed.

Exome sequencing reveals CCDC111 mutation associated with high myopia.

Myopia is a refractive error of the eye that is prevalent worldwide. The most extreme form, high myopia, is usually associated with other ocular disorders such as retinal detachment, macular degeneration, cataract, and glaucoma, and is one of leading causes of blindness. The etiology is complex and has not been fully elucidated.