Efficacy and safety of formula in the treatment of coronary microvascular disease: A randomized, double-blind, placebo-controlled clinical trial study.

Objective: The objective of this study was to evaluate the efficacy and safety of Formula in the treatment of coronary microvascular disease.

Methods: We conducted a randomized, double-blind, placebo-controlled study simultaneously in two hospitals, consisting of 80 participants. Using a random number table, we assigned patients to the treatment and control groups.

Efficacy and safety of Tongxin formula after stent implantation for acute coronary syndrome: A multicenter, double-blind, placebo-controlled randomized trial.

Objective: The aim of this study is to comprehensively evaluate both the efficacy and safety profile of integrating the Tongxin formula with optimal medical therapy (OMT) for patients experiencing acute coronary syndromes subsequent to coronary stenting, over the course of one year.

Methods: We enrolled 150 patients diagnosed with acute coronary syndromes who had received stent placement within one month and exhibited a TCM syndrome characterized by Qi deficiency and blood stasis. This group comprised patients with unstable angina, non-ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction.

Core-shell heterostructured Ni(OH)@activation Zn-Co-Ni layered double hydroxides electrode for flexible all-solid-state coaxial fiber-shaped asymmetric supercapacitors.

The increasing requirements for wearable and portable electronics are driving the interests of high performance fiber supercapacitor. Layered double hydroxide (LDH) is broadly used in electrode materials, owing to the adjustability of components and the unique lamellar structure. However, limited active sites and poor electrical conductivity hinder its applications.

Lightweight, flame retardant Janus carboxymethyl cellulose aerogel with fire-warning properties for smart sensor.

Lightweight, flame retardant biomass aerogels combining with multi-functionalities are promising for thermal insulation, noise absorption and smart sensors. However, high flammability hinders the application of these aerogels in extreme condition. Herein, lightweight, flame retardant aerogel with fire-warning properties fabricated from resource-abundant graphite and green carboxymethyl cellulose (CMC) is reported.

Versatile Liquid Metal/Alginate Composite Fibers with Enhanced Flame Retardancy and Triboelectric Performance for Smart Wearable Textiles.

Liquid metal (LM) shows the superiority in smart wearable devices due to its biocompatibility and electromagnetic interference (EMI) shielding. However, LM based fibers that can achieve multifunctional integrated applications with biodegradability remain a daunting challenge. Herein, versatile LM based fibers are fabricated first by sonication in alginate solution to obtain LM micro/nano droplets and then wet-spinning into LM/alginate composite fibers.

Measurement of the [Formula: see text]Ta([Formula: see text]) cross sections up to stellar s-process temperatures at the CSNS Back-n.

The neutron capture cross section of [Formula: see text]Ta is relevant to s-process of nuclear astrophysics, extraterrestrial samples analysis in planetary geology and new generation nuclear energy system design. The [Formula: see text]Ta([Formula: see text]) cross section had been measured between 1 eV and 800 keV at the back-streaming white neutron facility (Back-n) of China spallation neutron source(CSNS) using the time-of-flight (TOF) technique and [Formula: see text] liquid scintillator detectors. The experimental results are compared with the data of several evaluated libraries and previous experiments in the resolved and unresolved resonance region.

Ruthenium-catalysed decarboxylative unsymmetric dual -/-C-H bond functionalization of arenecarboxylic acids.

Here, we describe a ruthenium-catalysed decarboxylative unsymmetric -C-H azaarylation/-C-H alkylation a traceless directing group relay strategy. The installation of a 2-pyridyl functionality carboxyl directed -C-H activation is critical to promote decarboxylation and enable -C-H bond alkylation to streamline the synthesis of 4-azaaryl-benzo-fused five-membered heterocycles. This protocol is characterized by high regio- and chemoselectivity, broad substrate scopes, and good functional group tolerance under redox-neutral conditions.

Endothelial PHACTR1 Promotes Endothelial Activation and Atherosclerosis by Repressing PPARγ Activity Under Disturbed Flow in Mice.

Background: Numerous genome-wide association studies revealed that SNPs (single nucleotide polymorphisms) at the (phosphatase and actin regulator 1) locus strongly correlate with coronary artery disease. However, the biological function of PHACTR1 remains poorly understood. Here, we identified the proatherosclerotic effect of endothelial PHACTR1, contrary to macrophage PHACTR1.

Copper-Coordinated Cellulose Fibers for Electric Devices with Motion Sensitivity and Flame Retardance.

Nanocomposite conductive fibers are of great significance in applications of wearable devices, smart textiles, and flexible electronics. Integration of conductive nanomaterials into flexible bio-based fibers with multifunctionality remains challenging due to interface failure, poor flexibility, and inflammability. Although having broader applications in textiles, regenerated cellulose fibers (RCFs) cannot meet the requirements of wearable electronics owing to their intrinsic insulation.

Immature neutrophil is associated with coronary plaque vulnerability based on optical coherence tomography analysis.

Introduction: High neutrophil to lymphocyte ratio is considered to predict poor prognosis of acute coronary syndrome (ACS). However, the association of neutrophil subpopulation with plaque vulnerability and the incidence of ACS remains unknown.

Methods And Results: Blood samples from 48 patients with unstable angina (UA), 31 with ST-segment elevation myocardial infarction (STEMI) and 33 healthy controls were collected at admission.

Transportable, Endurable, and Recoverable Liquid Metal Powders with Mechanical Sintering Conductivity for Flexible Electronics and Electromagnetic Interference Shielding.

Liquid metals (LMs, e.g., EGaIn) promise a vast potential in accelerating the development of flexible electronics, smart robots, and wearable and biomedical devices.

Direct Synthesis of Adipic Esters and Adiponitrile via Photoassisted Cobalt-Catalyzed Alkene Hydrodimerization.

The direct hydrodimerization of acrylates and acrylonitrile offers a general streamlined access to industrially important intermediates to nylon 6,6. However, a practical catalytic method for this process has thus far underdeveloped owing to the challenges in regioselectivity and environmental compatibility of applied reagents. Here, we report a cobalt-catalyzed tail-to-tail hydrodimerization of activated alkenes driven by a visible-light photoredox catalysis at ambient temperature, which is applicable to both adipates and adiponitrile synthesis from potentially renewable feedstocks.

Flow and Heat Transfer Performances of Liquid Metal Based Microchannel Heat Sinks under High Temperature Conditions.

Developments in applications such as rocket nozzles, miniature nuclear reactors and solar thermal generation pose high-density heat dissipation challenges. In these applications, a large amount heat must be removed in a limited space under high temperature. In order to handle this kind of cooling problem, this paper proposes liquid metal-based microchannel heat sinks.

Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension.

Clinical trials of Dll4 (Delta-like 4) neutralizing antibodies (Dll4nAbs) in cancer patients are ongoing. Surprisingly, pulmonary hypertension (PH) occurs in 14% to 18% of patients treated with Dll4nAbs, but the mechanisms have not been studied. Here, PH progression was measured in mice treated with Dll4nAbs.

Liquid Metal Initiator of Ring-Opening Polymerization: Self-Capsulation into Thermal/Photomoldable Powder for Multifunctional Composites.

Liquid metal nanodroplets not only share similar metallic properties and nanoscale effect with solid metal nanoparticles, but also possess the additional uniqueness in nonvolatile fluidity and ambient sintering ability into continuous conductors. In most cases, liquid metal nanodroplets are encapsulated into ultrathin and fragile shells of oxides and amphiphile monolayers, and may be hindered from incorporating homogeneously into various composites through conventional processing methods. In this study, ring-opening polymerization is found to be initiated by sonicating the liquid metal EGaIn in fluidic lactones.

Quaternized Silk Nanofibrils for Electricity Generation from Moisture and Ion Rectification.

Protein nanostructures in living organisms have attracted intense interests in biology and material science owing to their intriguing abilities to harness ion transportation for matter/signal transduction and bioelectricity generation. Silk nanofibrils, serving as the fundamental building blocks for silk, not only have the advantages of natural abundance, low cost, biocompatibility, sustainability, and degradability but also play a key role in mechanical toughness and biological functions of silk fibers. Herein, cationic silk nanofibrils (SilkNFs), with an ultrathin thickness of ∼4 nm and a high aspect ratio up to 500, were successfully exfoliated from natural cocoon fibers quaternization followed by mechanical homogenization.

Pyrazole-Isoindoline-1,3-dione Hybrid: A Promising Scaffold for 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

The discovery of 4-hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.

Evaporation-induced sintering of liquid metal droplets with biological nanofibrils for flexible conductivity and responsive actuation.

Liquid metal (LM) droplets show the superiority in coalescing into integral liquid conductors applicable in flexible and deformable electronics. However, the large surface tension, oxide shells and poor compatibility with most other materials may prevent spontaneous coalescence of LM droplets and/or hybridisation into composites, unless external interventions (e.g.

Activation of Actuating Hydrogels with WS Nanosheets for Biomimetic Cellular Structures and Steerable Prompt Deformation.

Macroscopic soft actuation is intrinsic to living organisms in nature, including slow deformation (e.g., contraction, bending, twisting, and curling) of plants motivated by microscopic swelling and shrinking of cells, and rapid motion of animals (e.

Phospholipase Cγ1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.

Background: Vascular smooth muscle cell proliferation, migration, and dedifferentiation are critical for vascular diseases. Recently, it was demonstrated that Notch receptors have opposing effects on intima formation after vessel injury. Therefore, it is important to investigate the specific regulatory pathways that activate the different Notch receptors.