Synthesis and Biological Evaluation of Novel Piperidine-3-Carboxamide Derivatives as Anti-Osteoporosis Agents Targeting Cathepsin K.

A series of novel piperidamide-3-carboxamide derivatives were synthesized and evaluated for their inhibitory activities against cathepsin K. Among these derivatives, compound exhibited the most potent inhibition, with an IC value of 0.08 µM.

Quantitatively modeling of tetracycline photodegradation in low molecular weight organic acids under simulated sunlight irradiation.

As the ubiquitous active components in aquatic environments, low molecular weight organic acids (LMWOAs) have a large influence on the environmental behaviors of contaminants. This research was focused on the effect of different LMWOAs including 11 aliphatic acids and 7 aromatic acids on the photodegradation kinetics of tetracycline (TC), and the development of quantitative structure-activity relationship (QSAR) model. Results showed that TC photodegradation in the presence of LMWOAs fitted pseudo-first-order photolysis kinetics, and the observed photolysis rate constant (k) varied from 0.

One-step preparation of well-dispersed spindle-like FeO nanoparticles on g-CN as highly efficient photocatalysts.

Photocatalysis has attracted wide attention due to its outstanding advantages in dealing with sewage. And compounds of metal oxides and g-CN that possess Z-type heterojunctions have become the star photocatalysts in degrading pollutants. In this paper, a novel one-step method for the preparation of highly efficient photocatalyst of FeO/g-CN, using Fe (NO) and urea as raw materials, is described.