Publications by authors named "Xian-zhong Zhang"

Article Synopsis
  • Aging and obesity significantly impact public health by contributing to muscle atrophy and influencing muscle fiber types.
  • Research reveals that oxidative muscle fibers remain stable in proportion during aging and obesity, while glycolytic muscle fibers show a notable decrease in oxidative fiber proportion.
  • The study also highlights distinct genetic responses between the two fiber types, with glycolytic fibers upregulating atrophy and inflammation-related genes, and oxidative fibers demonstrating increased antioxidant expression, suggesting potential therapeutic targets for muscle-related diseases.
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Highly efficient sulfate reduction coupled to autotrophic denitrification plus nitrification is demonstrated by integrating an anaerobic membrane bioreactor (AnMBR) with a membrane aerated biofilm reactor (MABR). Concurrent chemical oxygen demand (COD) removal and sulfate reduction were accomplished in the AnMBR, while simultaneous nitrification and autotrophic denitrification were carried out in the MABR. Separate operation of the MABR achieved >90% total nitrogen (TN) removal when the N/S ratio was controlled at 0.

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Article Synopsis
  • * Results indicate that patients who underwent laparoscopic surgery experienced fewer complications, shorter hospital stays, and improved overall and disease-free survival rates.
  • * Key risk factors for complications and survival include hypoalbuminemia, older age, and TNM stage, with laparoscopic surgery being a significant protective factor against adverse outcomes.
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Background: Malnutrition and sarcopenia are common in elderly gastric cancer patients, which are also interrelated and affect each other. We aimed to determine the characteristics of coexistence of malnutrition and sarcopenia in the elderly gastric cancer patients and investigate the predictive roles of malnutrition and sarcopenia on clinical outcomes.

Methods: Between 2014 and 2019, a total of 742 elderly gastric cancer patients were enrolled.

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Background: Myosteatosis and sarcopenia are forms of muscle depletion that impair the normal physiological function of elderly patients, resulting in a worse prognosis. This study aimed to evaluate the prognostic value of sarcopenia and myosteatosis on postoperative outcomes in elderly patients with colorectal cancer.

Methods: From February 2015 to March 2021, a total of 921 elderly patients who underwent curative surgeries for colorectal cancer at 2 centers were enrolled and grouped by the presence of either myosteatosis or sarcopenia.

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Sarcopenia is negatively associated with clinical outcomes. However, the definitions of sarcopenia are inconsistent across international consensuses. Thus, the purpose of this study is to compare the impact of the basic definition components of sarcopenia and their combinations in post-operative complications and overall survival, aiming to find the best sarcopenia definition to stratify the prognosis in an Asian population.

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Background: The relationships between sarcopenia and postoperative outcomes in patients with early-stage gastric cancer who undergo radical gastrectomy is unclear. We aimed to investigate the predictive value of sarcopenia on adverse outcomes for stage I gastric cancer.

Methods: The clinical data of patients who underwent radical gastrectomy for stage I gastric cancer between July 2013 and May 2019 were prospectively collected.

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Objectives: The aim of this study was to determine the feasibility of substituting handgrip strength (HGS) for muscle mass as a constituent in the Global Leadership Initiative on Malnutrition (GLIM) to diagnose malnourished patients with gastrointestinal (GI) cancer.

Methods: The study included 2209 patients diagnosed with GI cancer from two centers. All patients were evaluated for nutritional risk using Nutritional Risk Screening 2002 within 24 h of admission.

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Objective: Although there is international consensus regarding the importance of cachexia, no tools exist, to our knowledge, for cachexia screening among patients with cancer. The aim of this study was to evaluate whether patients with cancer and cachexia could be identified using the four most commonly used nutritional screening tools: the Malnutrition Universal Screening Tool (MUST), the Nutritional Risk Screening (NRS)-2002, the Malnutrition Screening Tool (MST), and the Short Nutritional Assessment Questionnaire (SNAQ).

Methods: Clinical data were prospectively collected for patients who underwent elective radical gastrectomy for gastric cancer in two large centers between August 2014 and February 2018.

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Background: The association between sarcopenia and postoperative outcomes in patients who undergo laparoscopic-assisted gastrectomy is unclear. We aimed to determine the predictive value of sarcopenia for adverse postoperative outcomes after laparoscopic-assisted gastrectomy for gastric cancer.

Materials And Methods: We prospectively collected the clinical data of patients who underwent elective radical laparoscopic-assisted gastrectomy for gastric cancer in two large centers from August 2014 to October 2017.

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Aim: Mitochondrial dysfunction during aging is a key factor that contributes to sarcopenia. Nuclear factor erythroid 2-related factor 2 (Nrf2) has been increasingly recognized to regulate mitochondrial function. The present study aimed to investigate the role of Nrf2 in the development of frailty and sarcopenia during aging, and to demonstrate whether Nrf2 contributes to the maintenance of muscle mass and function by regulation of mitochondrial biogenesis and dynamics during the aging process.

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Objective: From gene lever identified the asexual stage of Taishan cordyceps.

Methods: Using rDNA ITS regions as molecular targets, PCR amplification, sequencing, and comparing with the other ITS region sequences of known.

Results: Through the Blast search of GenBank, the ITS sequence is same as the sequence of Paecilomyces tenuipes (100% ).

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Seasonal variations of self-purification ability for small natural shallow lakes in South Lake Taihu were investigated. The results showed that seasonal difference of self-purification of permanganate index, total nitrogen (TN), ammonium (NH4(+)-N), nitrate (NO3(-)-N), total phosphorus (TP), chlorophyll (Chl-a) in small shallow lakes were remarkable. Effects of self-purification were better in spring and winter, and were worse in summer by NH4(+)-N and NO3(-)-N and in autumn by TP and Chl-a.

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Two hundred and forty five human blood (whole blood) samples from Chinese donors aged from 0 to 90 yrs were analyzed for 10 perfluorinated compounds (PFCs). Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were the most abundant PFCs found in blood. The median concentration of PFOS was lower in nonadults (i.

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In this study, 10 perfluorochemicals (PFCs) were measured in meat, meat products, and eggs, and in indoor dust, collected in China. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) were the most frequently detected PFCs in these samples. Mean concentrations of PFOS and PFOA in foodstuffs were in the range of 0.

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Article Synopsis
  • The study aimed to assess how technetium galactosyl human serum albumin (99mTc-GSA) is taken up and distributed in mouse models with varying levels of liver damage.
  • Three mouse models were created to represent different liver conditions: hepatic fibrosis, hepatic cholestasis, and liver cancer, using specific methods for each model.
  • Results showed that while 99mTc-GSA concentrated in the liver of all models, the amount was significantly lower in those with liver injuries compared to healthy controls, indicating its potential use as a clinical marker for assessing liver health.
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Objective: To evaluate the relationship between atherosclerotic brain infarction (ABI) and human leukocyte antigen DR (HLA-DR) gene at molecular level.

Methods: By using polymerase chain reaction sequence specific probe (PCR-SSP), gene special position of the HLA-II DR alleles were determined in 31 patients and 30 healthy individuals as controls, all of them were inhabitants of Northeastern China.

Results: The HLA-DR B1*0301 gene frequency in the group of ABI was obviously higher than that of control group (RR=5.

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