Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances.

As the leading malignancy among women, breast cancer is a serious threat to the life and health of women. In this context, it is of particular importance that a proper therapeutic target be identified for breast cancer treatment. We collected the pathological tissues of 80 patients, with the view to discovering appropriate molecular targets for the treatment of breast cancer, this paper analyzes the expressions of ZNF436, β-catenin, EGFR and CMTM5 in breast cancer tissues, as well as their correlations with breast cancer in combination with the clinicopathologic characteristics of studied patients.

Surgical treatment of sacral fractures following lumbosacral arthrodesis: Case report and literature review.

Sacral fractures following posterior lumbosacral fusion are an uncommon complication. Only a few case series and case reports have been published so far. This article presents a case of totally displaced sacral fracture following posterior L4-S1 fusion in a 65-year-old patient with a 15-year history of corticosteroid use who underwent open reduction and internal fixation using iliac screws.

[Analysis of sagittal parameters about senior thoracolumbar proximal junctional kyphosis after lumbar long segment fusion].

Objective: To explore the radiographic risk factors of senior thoracolumbar proximal junctional kyphosis (PJK) after lumbar long segment fusion.

Methods: From January 2009 to December 2011, the PJK group enrolled 9 patients who satisfied the following criteria: being older than 60 years, having lumbar fusion operation no less than 4 levels, upper instrumented vertebrae being L1 or L2, emerging PJK in 2-year follow-up, and the control group enrolled 10 matched patients without PJK. Their sagittal parameters including sagittal vertical axis, thoracic kyphosis, lumbar lordosis, upper instrumented vertebral angle, pelvic incidence, sacral slope, pelvic tilt, lumbo-pelvic lordosis on full length spine lateral film were measured, the oswestry disability index (ODI ) scores of the two groups in the last follow up recorded, and the parameters and ODI scores of two groups compared.

[Retrospective study of complication of interspinous implants for degenerative lumbar disease].

Objective: To summarize and analyze the complications of interspinous implants for degenerative lumbar disease.

Methods: From September 2007 to September 2011, 177 cases with degenerative lumbar diseases were treated with interspinous implants. There were 99 male patients and 78 female patients, the average age was 44.

[Clinical characteristics and reoperation of symptomatic adjacent segment degeneration postoperation of lumbar fusion].

Objective: To evaluate the clinical characteristics and reoperation of symptomatic adjacent segment degeneration postoperation of lumbar fusion.

Methods: In the study, 28 cases of symptomatic adjacent segment degeneration postoperation of lumbar fusion from May 2007 to April 2012 were retrospectively reviewed,with an average age of (64.3±8.

[Analysis of risk factors for delirium in the elderly patients after spinal operation].

Objective: To explore the causes of high risk for the delirium of the elderly after spinal operation.

Methods: In the study, 116 cases of delirium were retrospectively analyzed from 1 216 patients aged more than 70 years who underwent spinal operation in general anesthesia from April 2007 to April 2011. Of the 116 patients, 62 were male and 54 female, with an average age of 75.

[Mid-term follow-up and analysis of the failure cases of interspinous implants for degenerative lumbar diseases].

Objective: To assess the indications,efficacy and safety of application of interspinous implants for degenerative lumbar diseases by mid-term follow-up and analysis of the failure cases.

Methods: In our study, 52 cases of degenerative lumbar diseases treated with interspinous implants From September 2007 to September 2008 were divided into Wallis group (25 cases) and Coflex group (27 cases). The clinical results were assessed by lumbar pain visual analog score (VAS) and lower limber pain VAS, lumbar Japanese Orthopedic Association (JOA) score and Prolo functional score; the radiological results including implant positon, segmental lodosis and segment movement degree were assessed by lumbar X ray post-operation compared with pre-operation.

[Prevention for venous thromboembolism prophylaxis after spinal surgery].

Objective: To investigate the efficacy and safety of venous thrombus embolism (VTE) prophylaxis according to risk stratifications after spinal surgery.

Methods: From June 2008 to June 2009, we separated 298 spinal patients who had different VTE risk factors into low-, medium- and high-risk groups for 22 cases, 48 cases and 228 cases respectively. Physical prevention measures such as thigh-length thromboembolic deterrent stockings (TEDS) and pneumatic sequential compression device (PSCD) were used in low- and medium-risk groups.

[Retrospective study of combined application of interspinous process fixation system and rigid fixation system for degenerative lumbar diseases].

Objective: To assess the efficacy and safety of combined application of interspinous process fixation system and rigid fixation system for degenerative lumbar diseases.

Methods: From September 2007 to September 2008, 16 cases with degenerative lumbar diseases were treated with combined application of interspinous process fixation system and rigid fixation system. The clinical results were assessed by VAS of pain of lumbar and lower limbs, lumbar JOA score and Prolo functional score.

[Distant pain after thoracolumbar compressive fracture].

Objective: To retrospectively analyze the causes and treatment of distant pain after thoracolumbar compressive fracture.

Methods: The investigators retrospectively analyzed 14 cases of thoracolumbar compressive fracture with distant pain, observed the pain region and its relationship with thoracolumbar compressive fracture and administered the treatment of pain.

Results: There were 14 cases of thoracolumbar compressive fracture with lumbar sacral pain whose painful region were located in paravertebral muscles (n = 6), near iliac crest (n = 5) and in hypochondrium (n = 3).

[Retrospective study of application of interspinous implants for degenerative lumbar diseases].

Objective: To assess the indications, efficacy and safety of applying interspinous implants for degenerative lumbar diseases.

Methods: From September 2007 to September 2008, 68 cases with degenerative lumbar diseases were treated with interspinous implants. The clinical outcome was assessed by VAS of pain in back and lower extremities, lumbar JOA score and Prolo functional score; the radiological results including implant position, segmental lodosis and segment movement degree were assessed by lumbar X ray including dynamic post-operative versus pre-operative X ray.

[Surgical treatment of cervical spondylotic amyotrophy].

Objective: To investigate the clinical characteristics and treatment of cervical spondylotic amyotrophy.

Methods: 9 cervical spondylotic amyotrophy patients and 15 cervical radiculopathy, myelopathy spondylosis patients were included in this study. Their clinical manifestation, MRI image results and treatment were analysis.

Systemic ischemic preconditioning plus hemodilution enhanced early functional recovery of reperfused heart in the rabbits.

We investigated whether transient systemic ischemia can precondition the heart against the ensuing ischemic insult. Rabbits were randomly divided into systemic ischemic preconditioning (SIP), hemodilution (HD) and control (C) groups. SIP was induced by rapidly withdrawing blood from femoral artery and maintaining the mean artery pressure at 50 mmHg for 10 min.

[Severe rigid kyphotic scoliosis treated with posterior spinal osteotomy].

Objective: To evaluate the effect of severe rigid kyphotic scoliosis treated with posterior spinal osteotomy

Methods: A total of 11 cases(average 11.2 years) of severe rigid kyphotic scoliosis treated with posterior spinal osteotomy from Mar. 2005 to Sept.

[Clinical character and treatment of coexistence of cervical spine disease and lumbar spine degenerative disease].

Objective: To investigate the clinical character and surgical management in coexistence of cervical and lumbar spine disease.

Methods: 53 cases with coexistence of cervical and lumbar spine disease were analyzed for clinical character and follow-up outcomes. 19 single cervical operation cases, 16 single lumbar operation cases and 7 combined cervical lumbar operation cases, all patients were recorded with JOA score.

Ginsenosides compound (shen-fu) attenuates gastrointestinal injury and inhibits inflammatory response after cardiopulmonary bypass in patients with congenital heart disease.

Objective: This study was undertaken to demonstrate that gastrointestinal mucosal injury occurs during cardiopulmonary bypass in children, increasing systemic inflammatory responses, and to determine whether shen-fu injection (the major components of which are ginsenosides compound, extract of Panax ginseng shown to have antioxidant properties) could attenuate gastrointestinal mucosal injury and subsequent inflammatory responses.

Methods: Twenty-four children undergoing heart surgery for congenital heart defects were randomly assigned to groups C (placebo control, n = 12) and G (1.35 mg/kg ginsenosides compound intravenously before and throughout the course of cardiopulmonary bypass, n = 12).

Propofol dose-dependently reduces tumor necrosis factor-alpha-Induced human umbilical vein endothelial cell apoptosis: effects on Bcl-2 and Bax expression and nitric oxide generation.

We investigated whether propofol can inhibit tumor necrosis factor (TNF)-alpha-induced apoptosis in cultured human umbilical vein endothelial cells (HUVECs). Isolated HUVECs were cultured in Dulbecco's modified Eagle medium supplemented with 20% bovine calf serum. HUVECs in untreated and propofol control groups were cultured at 37 degrees C for 24.

The effect of Shen-Fu on gastrointestinal tract injury and its potential mechanism during cardio-pulmonary bypass in patients undergoing cardiac surgery.

Objective: To investigate the effect of Shen-Fu (SF) injection on gastrointestinal tract injury and its potential mechanism.

Methods: Thirty-eight patients undergoing elective open heart surgery were assigned to Group C (control group, n=18) and Group SF (n=20) randomly. In Group SF, the patients received intravenous injection of SF (0.