Vasculature Characterization of a Multiterritory Perforator Flap: An Experimental Study.

 Tip necrosis in the perforator flap is a significant problem in clinical practice. This study aimed to characterize the vasculature of a multiterritory perforator flap using a rat model and to investigate the impact of the vasculature on flap survival.  In total, 105 Sprague Dawley rats were divided into seven groups, including the control, 3 hours postoperative (PO), 12 hours PO, 1 day PO, 3 days PO, 5 days PO, and 7 days PO.

The Effect of Inducible Nitric Oxide Synthase on Multiterritory Perforator Flap Survival in Rats.

 Inducible nitric oxide synthase (iNOS) plays an important role in vasodilation, angiogenesis, and ischemia-reperfusion injury. We investigated the effects of iNOS on the survival and choke vessels of multiterritory perforator flaps in rats.  In this study, 84 rats were divided into two groups of 42 rats each and subjected to multiterritory perforator flap operations.

Effects of calcitriol on random skin flap survival in rats.

Calcitriol, a metabolite of vitamin D, is often used in osteoporosis clinics. However, the material has other bioactivities; for example, it accelerates angiogenesis, has anti-inflammatory properties, and inhibits oxidative stress. We investigated the effects of calcitriol in a random skin flap rat model.