The study aimed to investigate the expression of SOCS-1/3 proteins and mRNA in PBMCs of patients with multiple organ dysfunction syndrome (MODS) and its relation to patient outcomes.
Researchers collected blood samples from 32 MODS patients and 24 healthy controls, using specific techniques to isolate and analyze SOCS expression.
Results indicated that while SOCS-1 mRNA was similar between groups, SOCS-1 protein levels were higher in MODS patients, and lower levels of SOCS-1 and higher levels of SOCS-3 were linked to worse prognosis in MODS patients.