Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates against Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

The COVID-19 pandemic has stimulated collaborative drug discovery efforts in academia and the industry with the aim of developing therapies and vaccines that target SARS-CoV-2. Several novel therapies have been approved and deployed in the last three years. However, their clinical application has revealed limitations due to the rapid emergence of viral variants.

Prediction of prognosis of patients with hepatocellular carcinoma based on immune-related score.

Background: Immune-related scores are currently used for prognostic evaluation and as an immunotherapy reference in various cancers. However, the relationship between immune-related score and hepatocellular carcinoma (HCC) prognosis has not yet been investigated. This study aimed to explore the clinical application value of immune-related score for predicting HCC prognosis-related indicators including disease-free survival (DFS) and overall survival (OS), and to construct a clinical nomogram prediction model related to verification.

Oral GS-441524 derivatives: Next-generation inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase.

GS-441524, an RNA-dependent RNA polymerase (RdRp) inhibitor, is a 1'-CN-substituted adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral bioavailability of GS-441524 poses a challenge to its anti-SARS-CoV-2 efficacy. Remdesivir, the intravenously administered version (version 1.

Nomogram for prediction of peritoneal metastasis risk in colorectal cancer.

Objective: Peritoneal metastasis is difficult to diagnose using traditional imaging techniques. The main aim of the current study was to develop and validate a nomogram for effectively predicting the risk of peritoneal metastasis in colorectal cancer (PMCC).

Methods: A retrospective case-control study was conducted using clinical data from 1284 patients with colorectal cancer who underwent surgery at the First Affiliated Hospital of Guangxi Medical University from January 2010 to December 2015.

Bioactive natural products in COVID-19 therapy.

The devastating COVID-19 pandemic has caused more than six million deaths worldwide during the last 2 years. Effective therapeutic agents are greatly needed, yet promising magic bullets still do not exist. Numerous natural products (cordycepin, gallinamide A, plitidepsin, telocinobufagin, and tylophorine) have been widely studied and play a potential function in treating COVID-19.

Dynamics and sources of colloids in shallow groundwater in lowland wells and fracture flow in sloping farmland.

Field-scale studies of natural colloid mobilization and transport in finely fractured aquifer as well as the source identification of groundwater colloids are of great importance to the safety of shallow groundwater. In this study, the daily monitoring of fracture flow from a sloping farmland plot and the biweekly monitoring of three lowland shallow wells within the same catchment were carried out simultaneously in 2013. The effects of physicochemical perturbations on groundwater colloid dynamics were explored in detail using partial redundancy analysis, structural equation modeling, Pearson correlation and multi-linear regression analyses.

[Transport of Nitrogen and Phosphorus from Sloping Farmland with Thin Purple Soil Overlying Rocks].

In a sloping farmland plot(1500 m) of purple soil with underlying fractured mudrock in Southwest China, field monitoring and sampling campaigns were undertaken to explore the mechanisms of surface and subsurface transport of nitrogen and phosphorus upon two representative rain events in the summer of 2015. The results indicated that:1depths of surface runoff and subsurface fracture flow as well as average colloid export flux were dependent on antecedent soil wetness and rainfall amount, while discharge dynamics and colloid peak concentration were determined by rainfall intensity; 2nitrogen export was mainly in dissolved forms through subsurface fracture flow, however, phosphorus was mainly transported in particle-associated forms through surface runoff; 3the transport of nitrogen and phosphorus was strongly influenced by hydrological processes, with nitrogen and phosphorus transport being controlled by fracture flow and surface runoff, respectively. Our findings contribute significantly to the knowledge of nitrogen and phosphorus export from sloping farmland with thin soil underlain by fractured rock upon rainfall, and on the other hand this study provides reliable field data in support of developing effective approaches for controlling agricultural non-point source pollution of N and P and identifying key hydrological processes to be manipulated.

[Seasonal Variation of Colloid Particles in the Shallow Well Water of a Small Watershed of Purple Soil].

Colloids are the major carriers of various contaminants during the downward transport into groundwater.To explore the long-term dynamics of colloid in the groundwater and its influencing factors,a one-year monitoring of colloid concentration and water physicochemical parameters was carried out in the shallow wells in a purple soil dominated watershed in the hilly region of central Sichuan.The results indicated that colloid concentrations within a year had a strong seasonal variation with the coefficient of variation being larger than 0.

Patients with chronically diseased livers have lower incidence of colorectal liver metastases: a meta-analysis.

Background: 70 years ago, it was put forward that the diseased liver was not a favorable soil for metastatic tumor cells. In addition, a few studies have demonstrated that rare occurrence of colorectal liver metastases among patients with fatty liver, cirrhosis or chronic hepatitis B and C virus infection. We performed a meta-analysis to verify the association between the incidences of colorectal liver metastases with chronically diseased livers.