The study investigates the protective effects of total alkaloids (TA) from Coptis chinensis against alcohol-induced gastric lesions in rats, focusing on various gastric damage indicators.
TA demonstrated a dose-dependent reduction in gastric damage caused by ethanol, proving more effective than cimitidine and berberine at specified doses, while also affecting gastric acid secretion.
The findings suggest that TA helps protect the gastric mucosa by inhibiting acid secretion and mitigating oxidative stress markers, emphasizing its potential as a therapeutic agent for gastric damage.