Publications by authors named "Xian-fu Sun"
Article Synopsis
- The study aimed to compare the effectiveness of weekly nab-paclitaxel versus the standard treatment of docetaxel plus carboplatin, both combined with trastuzumab and pertuzumab, for patients with HER2-positive early-stage breast cancer.
- HELEN-006 was a phase 3 trial conducted across six hospitals in China, enrolling 689 patients with untreated, confirmed stage II-III HER2-positive breast cancer, who were randomly assigned to one of the two treatment groups.
- The trial's final analysis focused on the primary endpoint of pathological complete response, with ongoing follow-up for the adjuvant phase, and the trial is registered under ClinicalTrials.gov (NCT04547907).
Introduction And Objectives: Hepatocellular carcinoma (HCC) is one of the most common and fatal tumors in the world, ranking third in cancer-related mortality. Chronic HBV infection is one of the major risk factors for hepatocellular carcinoma in China, Korea, and Sub-Saharan Africa. The HBx protein encoded by the X gene of HBV is a broadly regulated protein involved in transcriptional activation, epigenetics, apoptosis, DNA repair, and other regulatory processes.
View Article and Find Full Text PDFBackground: Pathological examination of liver biopsies remains the gold standard for evaluating the stage of hepatic fibrosis, which are a number of disadvantages associated with biopsy. The aim of the present study was to investigate the potential of exosomal microRNA (miR)-155 as a non-invasive biomarker for the diagnosis and progression of hepatic fibrosis.
Methods: Exosomal miR-155 quantity was analyzed by sampling serum exosomes of patients with hepatic fibrosis and a hepatic fibrosis rat model.
Background: Ipsilateral supraclavicular lymph node metastasis (ISLM) with breast cancer patients has always been a hard problem for breast surgery. It is generally believed that radiotherapy can benefit the survival of patients, but whether local surgical resection is needed or not is controversial. The study aims to compare the efficacy between supraclavicular lymph node (SLN) dissection combined with radiotherapy and radiotherapy alone in the treatment of breast cancer with ISLM.
View Article and Find Full Text PDFType 2 diabetes mellitus (T2DM) has been considered to be a risk factor for numerous human cancers. Hyperglycemia is one of the most direct internal environmental changes for patients with T2DM. Increasing evidence reveals that a high concentration of glucose can promote tumor progression, while its role for migration and invasion of invasive ductal breast carcinoma (IDBC) cells remains unclear.
View Article and Find Full Text PDFTamoxifen-resistant breast cancer cells possess cancer stem-like cell properties.
Chin Med J (Engl)
August 2013
Background: Cancer stem cells (CSCs) are the cause of cancer recurrence because they are resistant to conventional therapy and contribute to cancer growth and metastasis. Endocrinotherapy is the most common breast cancer therapy and acquired tamoxifen (TAM) resistance is the main reason for endocrinotherapy failure during such therapy. Although acquired resistance to endocrine treatment has been extensively studied, the underlying mechanisms are unclear.
View Article and Find Full Text PDFBioinformatics analysis of breast cancer bone metastasis related gene-CXCR4.
Asian Pac J Trop Med
September 2013
Article Synopsis
- This study aimed to investigate the role of the gene CXCR4 in breast cancer bone metastasis using high-flux gene chip screening.
- The results showed that out of 396 genes analyzed, CXCR4 was significantly up-regulated in tissues with bone metastasis compared to those without, indicating its crucial involvement in this process.
- The findings suggest that bioinformatics analysis of CXCR4 could help in understanding, diagnosing, and developing targeted gene therapies for breast cancer bone metastasis, as well as predicting patient prognosis.
[Effects of high glucose on in vitro invasiveness of human breast cancer cell line MDA-MB-435].
Zhonghua Yi Xue Za Zhi
January 2013
Article Synopsis
- * Results show that as glucose concentration increases (from 5.5 to 25 mmol/L), the number of invasive cancer cells also rises significantly, along with increased expression of certain proteins (MMP-9/MMP-2) and decreased expression of E-cadherin.
- * The findings suggest that high glucose levels enhance the invasiveness of breast cancer cells by altering the expression of key proteins involved in cell movement and adhesion.
Objective: To investigate the approaches to improve therapeutic effect of stomach cancer by analysis of the long-term results of surgical treatment of this disease.
Methods: Prognostic factors of stomach cancer were analyzed by Cox multivariate regression model based on clinical data of 2561 stomach cancer cases who underwent surgical treatment from 1964 to 2004 at Sun Yat-sen University Cancer Center. Survival rates were calculated by life table method.