Baseline theta activities in medial prefrontal cortex and deep cerebellar nuclei are associated with the extinction of trace conditioned eyeblink responses in guinea pigs.

It has been shown that both the medial prefrontal cortex (mPFC) and the cerebellum are involved in the extinction of trace conditioned eyeblink responses (CR). However, the neural mechanisms underlying the extinction are still relatively unclear. Theta oscillation in either the mPFC or the cerebellum has been revealed to correlate with the performance of trace CRs during the asymptotic acquisition.

Predictive nature of prefrontal theta oscillation on the performance of trace conditioned eyeblink responses in guinea pigs.

Stimulus-evoked theta oscillations are observed in the medial prefrontal cortex (mPFC) when executing a variety of learning tasks. Here, we aimed to further determine whether spontaneous theta-band (5.0-10.