[Math1 gene therapy for kanamycin and furosemide-induced deaf guinea pigs].

Objective: To observe the morphology and function changes of cochlear hair cells before and after math1 gene injection into the cochlea of deaf guinea pigs which were induced by kanamycin and furosemide. To explore the feasibility of Math1 gene for medicine-induced deafness therapy.

Methods: Kanamycin (500 mg/kg) and furosemide (50 mg/kg) were given to the healthy adult guinea pigs intramuscularly and intravenously to establish the deafness model.

[Surgical management and prognosis of iatrogenic peripheral facial nerve injury following middle ear surgery].

Objective: To discuss the causes, sites, management strategies and curative effects of accidental facial nerve paralysis in the middle ear surgery.

Methods: Forty two cases with peripheral facial nerve paralysis following middle ear surgery who underwent surgical exploration and reanimation were analyzed. Facial nerve decompression, primary end-to-end anastomosis, interpositional nerve grafts with the great auricular nerve and nerve substitution of facial-hypoglossal anastomosis were applied to restoration of the facial nerve function.