Publications by authors named "Xian-di Chen"
Emergence of eravacycline heteroresistance in carbapenem-resistant isolates in China.
Front Cell Infect Microbiol
April 2024
Article Synopsis
- Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a challenge to antibiotic treatment, but eravacycline shows promise as a potential treatment option; however, its resistance mechanisms remain unclear.
- A study of 287 CRAB isolates from China identified that approximately 17% exhibited heteroresistance to eravacycline, mainly among strains that also produced the OXA-23 carbapenemase, with a significant correlation to higher expression levels of certain resistance genes.
- The study found that the presence of efflux pump inhibitors could reduce eravacycline resistance, indicating potential avenues for improving treatment strategies against CRAB infections. *