Publications by authors named "Xian-Zhen Liao"
Projection of Premature Cancer Mortality in Hunan, China, Through 2030: Modeling Study.
JMIR Public Health Surveill
March 2023
Background: The United Nations Sustainable Development Goals for 2030 include reducing premature mortality from noncommunicable diseases by one-third. Although previous modeling studies have predicted premature mortality from noncommunicable diseases, the predictions for cancer and its subcategories are less well understood in China.
Objective: The aim of this study was to project premature cancer mortality of 10 leading cancers in Hunan Province, China, based on various scenarios of risk factor control so as to establish the priority for future interventions.
Article Synopsis
- - Lung cancer is the most common cancer and a major cause of cancer deaths in China, prompting a study to assess the direct medical costs associated with its care from 2002 to 2011.
- - The study analyzed data from 15,437 patients across 13 provinces, revealing that the average medical expenditure per lung cancer case in 2011 was 39,015 CNY (about US$6,041), with a 7.55% annual increase over the period.
- - Drug costs constituted the largest share of medical expenses at 54.27%, with treatment and surgical costs following behind; costs varied significantly depending on regional factors and hospital types.
Background: Upper gastrointestinal precancerous lesions (UGPL) is the major preventable disease in non-high-incidence area. A prognostic nomogram was constructed to predict and identity susceptible population of UGPL before endoscope screening.
Methods: We recruited 300 ,016 eligible participants for upper gastrointestinal cancer (UGC) screening aged 40-74 years from two cities in Hunan province from 2012 to 2019.
Purpose: To compare the performance of three-level EuroQol five-dimensions (EQ-5D-3L) and five-level EuroQol five-dimensions (EQ-5D-5L) among common cancer patients in urban China.
Methods: A hospital-based cross-sectional survey was conducted in three provinces from 2016 to 2018 in urban China. Patients with breast cancer, colorectal cancer, or lung cancer were recruited to complete the EQ-5D-3L and EQ-5D-5L questionnaires.
Article Synopsis
- This study examined the health-related quality of life (HRQoL) of colorectal precancer and cancer patients in China, using data collected from a cross-sectional survey conducted from 2012 to 2014 across 12 provinces.* -
- A total of 376 precancer and 2,470 CRC patients participated, with utility scores indicating a significant decline in HRQoL compared to the general population, particularly noting pain and discomfort as major issues.* -
- Multivariate analysis identified various factors influencing utility scores including treatment type, education, income, and geographic location, suggesting the need for tailored interventions and further evaluations in healthcare.*
Article Synopsis
- A cluster-randomized controlled trial was carried out in two urban cities in China to assess the effectiveness of a screening method for upper gastrointestinal cancer (UGC) using questionnaires and endoscopies in areas with low UGC incidence.
- The study involved 75 communities split into a screening group (38 communities) and a control group (37 communities), with a participation rate of 74.3% and over 10,000 individuals recruited.
- Results indicated that while the screening identified a small number of early-stage cancers and precancerous lesions, the overall detection rate was low, suggesting a need for improved community-based screening strategies in such low-incidence areas.
Article Synopsis
- - The study aims to understand how participation in breast cancer screening programs affects health-related quality of life (HRQoL), with data gathered from a survey across 12 provinces in China.
- - Results showed that while utility scores (a measure of HRQoL) for those in the screening group were lower than those of the general population (0.937 vs. 0.953), issues like pain, discomfort, and anxiety/depression were common in both groups.
- - The findings highlight the need for further research, as utility scores decreased temporarily during screening but indicated potential improvements afterward, suggesting that the difference in scores might not be clinically significant.
Background: Most lung cancer patients are diagnosed after the onset of symptoms. However, whether the symptoms of lung cancer were independently associated with the diagnosis of lung cancer is unknown, especially in the Chinese population.
Methods: We conducted a 10 years (2005-2014) nationwide multicenter retrospective clinical epidemiology study of lung cancer patients diagnosed in China.
Background: The study was conducted to examine changes in diagnostic and staging imaging methods for lung cancer in China over a 10-year period and to determine the relationships between such changes and socioeconomic development.
Methods: This was a hospital-based, nationwide, multicenter retrospective study of primary lung cancer cases. The data were extracted from the 10-year primary lung cancer databases at eight tertiary hospitals from various geographic areas in China.
Objectives: This study aimed to explore the clinical profile and its trajectory of lung cancer on clinicopathological characteristics and medical service utilization in China.
Methods: Patients diagnosed with primary lung cancer in tertiary hospitals during 2005-14 were selected from seven geographic regions of China. Data on clinical characteristics and medical service utilization was extracted from medical record, and the ten-year trends were explored.
Article Synopsis
- Stomach cancer is a significant health issue in China, ranking as the third most common cancer and a leading cause of cancer deaths, prompting a study on the medical expenses related to treatment.
- A study involving 14,692 patients revealed that medical expenses for the first course of treatment increased from an average of around 20,000 CNY in 2002 to about 43,249 CNY (6851 USD) in 2011, marking an annual increase of 7.4%.
- The rising costs are primarily attributed to longer hospital stays and more treatment episodes, with drug expenses comprising over half of the total medical costs.
Article Synopsis
- - This study focused on assessing the health-related quality of life and utility scores for patients with breast cancer and precancerous lesions in China, an area with limited existing data.
- - Researchers conducted a survey in 12 provinces over two years (2013-2014) using the EuroQol-5-Dimension instrument, which revealed that breast cancer patients reported an average utility score of 0.887, while precancer patients had a score of 0.781, with pain and discomfort being the most significant issues.
- - The findings indicate that utility scores decrease as the severity of breast cancer increases, highlighting the importance of these scores for future cost-utility analyses in the region.
Article Synopsis
- - This study investigates liver cancer medical costs in urban China from 2002 to 2011, revealing a significant rise in average treatment expenses from ¥21,950 to ¥40,386 over the decade.
- - An analysis of 12,342 patients shows that pharmaceutical expenses constitute the largest portion of costs, rising from 48.01% to 52.96%, while nursing fees remain minimal at about 1%.
- - The findings indicate that liver cancer imposes a heavy economic burden on families, with early diagnosis and treatment potentially reducing costs; expenditures are notably higher in the eastern region compared to the west and central areas.
Purpose: This study aimed to construct two prognostic nomograms to predict survival in patients with non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) using a novel set of clinical parameters.
Patients And Methods: Two nomograms were developed, using a retrospective analysis of 5384 NSCLC and 647 SCLC patients seen during a 10-year period at Xiang Ya Affiliated Cancer Hospital (Changsha, China). The patients were randomly divided into training and validation cohorts.
Background: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated trends.
View Article and Find Full Text PDFAim: We aimed to assess economic burden of breast cancer (BC) diagnosis and treatment in China through a multicenter cross-sectional study, and to obtain theoretical evidence for policy-making.
Methods: This survey was conducted in 37 hospital centers across 13 provinces in China from September 2012 to December 2014. We collected information on the subject characteristics.
Background: The increasing prevalence of colorectal cancer (CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.
Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014.