[Renal Injury and Its Mechanisms in Mice].

Objective: To study the mechanism of renal injury in mice with the leptin receptor homozygous deficiency.

Methods: Ten male of 28-week-old mice with leptin receptor heterozygous deficiency were selected as control group and ten male mice with leptin receptor homozygous deficiency were used in this study. After fasting for 8 hours, the body mass, fasting blood glucose (FBG) and glycosylated hemoglobulin (HbA1c) of the mice were measured.