Publications by authors named "Xian-Wen Ye"
Article Synopsis
- * Ginsenosides, key compounds found in red ginseng, undergo significant changes during processing, which enhances their pharmacological effects compared to white ginseng.
- * This paper reviews the different ginsenosides, their pharmacological activities, the processing transformations, and clinical trials of red ginseng products, aiming to support the future industrialization of red ginseng.
Background: Alzheimer's Disease (AD) and Type 2 Diabetes Mellitus (DM) have an increased incidence in modern society. Although more and more evidence has supported that DM is prone to AD, the interrelational mechanisms remain fully elucidated.
Purpose: The primary purpose of this study is to explore the shared pathophysiological mechanisms of AD and DM.
Purpose: The possible mechanism of Xiyanping injection treatment COVID-19 is discussed through the network pharmacology.
Methods: Obtaining the chemical structure of Xiyanping injection through the patent application and obtaining control compounds I, II, III, IV, V, Yanhuning injection (VI, VII), Chuanhuning injection (VIII, IX), 10 compounds were analyzed by D3Targets-2019-nCoV. The human anti-COVID-19 gene in COVID-19 DisGeNET was intersected with the CTD Andrographolide target gene and then combined with D3Targets-2019-nCoV, resulting in 93 genes, using the Venny 2.
Background: Alzheimer's disease (AD) is becoming a more prevalent public health issue in today's culture. The experimental study of Coptidis Rhizoma (CR) and its chemical components in AD treatment has been widely reported, but the principle of multi-level and multi-mechanism treatment of AD urgently needs to be clarified.
Objective: This study focuses on network pharmacology to clarify the mechanism of CR's multi-target impact on Alzheimer's disease.
Article Synopsis
- * Researchers identified 45 active components in SQW and 72 potential COVID-19-related targets, highlighting key proteins such as ACE2 and IL-6, and found significant enrichment in 1715 gene ontology (GO) projects and 136 KEGG pathways related to inflammation and cellular response.
- * Molecular docking studies indicated strong binding capabilities of several active compounds like kaempferol and quercetin with important COVID-19 targets, suggesting SQW could be effective in managing the disease.
Article Synopsis
- This study explores how the combination of Platycodonis Radix and Lilii Bulbus might help treat pneumonia using network pharmacology and lab experiments.
- Researchers identified 12 active components from the two plants that target pneumonia-related pathways, focusing on inflammation and cell growth.
- The findings suggest these components effectively bind to key targets, and lab tests confirm they can reduce the expression of important inflammatory markers like MMP9 and TNF-α.
Polygonati Rhizoma(PR), listed as a top-grade medicine, was recorded first in the Mingyi Bielu written by TAO Hongjing. It is a good medicine through the ages to tonify Qi and nourish Yin, strengthen spleen and kidney. PR has a long history of processing and has a variety of processing methods and technologies.
View Article and Find Full Text PDFBackground: Paeoniae Radix Alba, the root of the plant Paeonia lactiflora Pall, is a common blood-enriching drug in traditional Chinese medicine. Its effectiveness in the clinical treatment of anaemia is remarkable, but its potential pharmacologic mechanism has not been clarified.
Methods: In this study, the potential pharmacologic mechanism of Paeoniae Radix Alba in the treatment of iron-deficiency anaemia was preliminarily elucidated through systematic and comprehensive network pharmacology.