A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation.

Aims: The present study aimed to disclose a potent and selective GPR120 agonist LXT34 and its anti-diabetic effects.

Main Methods: Calcium mobilization assay was used to measure the agonistic potency and selectivity of LXT34 in GPR120 or GPR40-overexpression Chinese hamster ovary (CHO) cells. Glucagon-like peptide-1 (GLP-1) release and glucose-stimulated insulin secretion (GSIS) were evaluated in human colonic epithelial cell line NCI-H716 and mouse insulinoma cell line MIN6 by enzyme-linked immunosorbent assay (ELISA), respectively.