The Novel HLA-C*03:681 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.

The HLA-C*03:681 allele differs from HLA-C*03:02:02:01 by a single non-synonymous nucleotide change in exon 3.

An effective treatment and suspicious adverse reaction to Ibrutinib in a patient diagnosed with splenic B-cell lymphoma/leukaemia with prominent nucleoli: A first case report.

Rationale: Splenic B-cell lymphoma/leukemia with prominent nucleoli (SBLPN) is a new classification, which is so rare that it lacks clinical data.

Patient Concerns: An increased proportion of prolymphocytes (84%) in the bone marrow smear. Whole exon sequence analysis revealed a TP53 mutation.

N NMR as a General Tool to Characterize the Nitrogen-Containing Species and Monitor the Nitration Process.

The usefulness of N NMR spectroscopy was highly underestimated compared with N NMR, which usually required tedious and expensive N-labeling manipulations. It is of great significance to make the N NMR spectroscopy convenient and useful considering N nuclei's high natural abundance of 99.6%.

N Solid-State NMR as Bright Eyes to See the Isomerization of the Azo Bond: Revision of Tris(β-hydroxyl-azo)-benzene to Tris(β-keto-hydrazo)-cyclohexane in Porous Organic Polymers.

Porous organic polymers (POPs) have aroused great and wide attention from the materials community, while the identification of their precise structures is still very challenging. The well-defined structures are of great importance in understanding the relationship between the structure and function of the polymer materials, though they are sometimes ignored and do not receive enough attention. In this letter, an efficient N labeling technique and N solid-state NMR (N-SSNMR) were combined to obtain strong evidence for the presence of the azo bond and keto-hydrazone structure in the solid state.

Irreversible tautomerization as a powerful tool to access unprecedented functional porous organic polymers with a tris(β-keto-hydrazo)cyclohexane subunit (TKH-POPs).

Porous organic polymers (POPs) have received much attention, due to their multiple potential applications and flexibility in chemical structure design. Creation of a novel chemical structure has been the central task in the research of POPs, which are usually constructed by direct coupling polymerizations. The fascinating rearrangement/tautomerization could lead to some novel structures, which are hard to access by conventional direct coupling polymerizations.

Distinguishing iron deficiency anemia from thalassemia by the red blood cell lifespan with a simple CO breath test: a pilot study.

Background: Extant indices for distinguishing between iron deficiency anemia (IDA) and thalassemia (Thal) have substantial practical limitations. The aim of this pilot study was to assess the predictive value of red blood cell lifespan (RBCLS), as determined by an automated CO breath test analysis approach, in the differential diagnosis of these two common forms of microcytic hypochromic anemia (MHA).

Methods: RBCLS measurements were conducted in 35 healthy controls (HCs) and 114 patients diagnosed with MHA (IDA, N = 59; and Thal, N = 55) with ELS TESTER that provides a direct RBCLS value read-out.