Publications by authors named "Xian-Qiu Wu"
This study investigated the expression, clinicopathological significance and mechanism of action of TIMELESS, a mammalian homolog of a Drosophila circadian rhythm gene, in nasopharyngeal carcinoma. Quantitative real-time PCR, western blotting and immunohistochemistry revealed TIMELESS was upregulated in NPC cell lines (n = 8 vs. NP69 cells), and freshly-frozen (n = 6) and paraffin-embedded human NPC specimens (n = 108 vs.
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- Kinesin family member 20A (KIF20A) is found to be overexpressed in nasopharyngeal carcinoma (NPC) and is linked to worse patient outcomes and various clinicopathological features.
- KIF20A expression was quantitatively assessed in NPC cell lines and patient samples, revealing high levels in 42.9% of tested specimens, which correlates with factors like clinical stage and survival rates.
- Silence KIF20A reduced the ability of NPC cells to migrate and invade, suggesting that it not only serves as a prognostic biomarker but also as a potential target for therapeutic intervention in NPC.