Publications by authors named "Xian-Qi Gao"
Neuroinflammation plays a pivotal role in the pathogenesis of Parkinson's disease. Ginsenoside Rg1, the most active ingredient of ginseng, has been reported to exert neuroprotective effects via estrogen and glucocorticoid receptors. The present study evaluated the involvement of the G protein-coupled estrogen receptor (GPER) in the anti-inflammatory effects of ginsenoside Rg1 against lipopolysaccharide (LPS)-induced microglia activation in the BV2 microglial cell line and ventral mesencephalic primary microglial culture.
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- Chronic neuroinflammation is linked to the death of dopaminergic neurons in Parkinson's disease, and ginsenoside Rg1 from ginseng shows potential for neuroprotection.
- Research indicates that Rg1 can improve behavior in rat models and reduce the loss of important neurons while decreasing harmful inflammatory markers after inducing inflammation with LPS.
- The protective effects of Rg1 may involve the glucocorticoid receptor (GR) signaling pathway, as its efficacy can be diminished by a GR antagonist.