Publications by authors named "Xian-Ping Huang"
[The screening and the functional pathway analysis of differential genes correlated with coronary heart disease of blood stasis syndrome].
Zhongguo Zhong Xi Yi Jie He Za Zhi
October 2012
Objective: To explore the function and target pathway of the correlated differential gene of coronary heart disease (CHD) of blood stasis syndrome (BSS).
Methods: Patients of the genealogical CHD of BSS (group A) and the genealogical CHD of non-BSS (group B), the genealogical non-CHD of BSS (group C), the genealogical healthy subjects (group D), the non-genealogical CHD of BSS (group E), the non-genealogical healthy subjects (group F) were recruited in this study. The differential gene expression spectrums were studied using gene chip technique.
[Metabolomics study of the myocardial tissue of rats of cardiac blood stasis syndrome].
Zhongguo Zhong Xi Yi Jie He Za Zhi
April 2012
Objective: To find out the metabolite profile of rats' myocardial tissue of cardiac blood stasis syndrome (CBSS), and to analyze the metabolic pathway of CBSS rats' myocardial tissue by observing the changes of phenotypes intervened by Yangxin Tongmai Recipe (YTR).
Methods: Acute myocardial infarction (AMI) rat model of CBSS was prepared by ligating the left anterior descending coronary artery. Meanwhile, the model was interfered with YTR.
[Detection and analysis on plasma metabolomics in patient with coronary heart disease of Xin-blood stasis syndrome pattern].
Zhongguo Zhong Xi Yi Jie He Za Zhi
June 2010
Objective: To research the plasmic metabolites and metabolic pathway of Xin-blood stasis syndrome (XBSS).
Methods: Plasma metabolic products in patients of coronary heart disease (CHD) with XBSS or non-XBSS and subjects in the control group were identified by gas chromatographic mass spectrometry (GC-MS) type QP2010, the changes of their main elements in different groups were analyzed by principal components analysis (PCA) and partial least squares (PLS) analysis.
Results: PCA showed that as compared with that in the control group, in the CHD-XBSS group, contents of lactic acid, beta-hydroxy butanoic acid, urea, oleic acid, octadecanoic acid and arachidonic acid were higher and that of citric acid was lower.
[Analysis of the function of vascular endothelial cells in coronary heart disease patients of blood-stasis syndrome].
Zhongguo Zhong Xi Yi Jie He Za Zhi
May 2006
Objective: To explore the function of vascular endothelial cell (VEC) in patients with coronary heart disease (CHD) of Xin-blood-stasis syndrome.
Methods: Some vasoactive substances produced by VEC were detected and analyzed in patients with CHD of or without Xin blood stasis syndrome in group A (n=112) and group B (n=108) respectively, also in patients with non-CHD but of Xin-blood-stasis syndrome in group C (n=110), and healthy persons in group D (n=100), including nitric oxide (NO), endothelin (ET), angiotensin H (Ag II), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule -1 (sVCAM-1).
Results: The abnormality degree of ET, Ag II , sICAM-1 and sVCAM-1 in various groups showed such a tendency as group A> group B> group D (P < 0.
[Study on relationship between the polymorphism of angiotensin converting enzyme gene and blood stasis syndrome in patients with coronary heart disease].
Zhongguo Zhong Xi Yi Jie He Za Zhi
September 2004
Article Synopsis
- The study investigates the link between angiotensin converting enzyme (ACE) gene polymorphism and blood stasis syndrome (BSS) in coronary heart disease (CHD) patients.
- Researchers analyzed ACE gene types and measured levels of certain biomarkers (endothelin, angiotensin II, and nitric oxide) in CHD patients with and without BSS, as well as in healthy controls.
- Results show a higher occurrence of the DD genotype of ACE in BSS patients, along with elevated levels of endothelin and angiotensin II, suggesting that this genotype may increase susceptibility to CHD in BSS patients.