Ultrasound-Activated Near-Infrared-II Afterglow Luminescence for Precise Cancer Imaging.

Afterglow fluorescence imaging has been extensively assessed in ultrasensitive bioimaging. Since it eliminates the need for real-time excitation light and thereby circumvents the autofluorescence background of tissue, it holds tremendous potential in accurate biomedical imaging. However, current afterglow probes are rare and emit light only in the visible to near-infrared (NIR) range, which is inadequate for imaging.

Prolonged Immunomodulator Delivery Boosts Monocyte Exosome Secretion and Elevates Cathelicidin/LL-37 Content.

Human cathelicidin LL-37 offers significant benefits to the immune system and in treating various diseases, but its therapeutic potential is hindered by low activity and instability in physiological environments. Here, we introduce a strategy to boost LL-37 levels in exosomes derived from THP-1 monocytes by incubating cells with electrospun nanofibers containing immunomodulators (e.g.

Polyvalent Aptamers Structure-Mediated Fluorescent Aptasensor for the Early Diagnosis of Alzheimer's Disease by Coupling with HCR and CRISPR-Cas System.

The early diagnosis of Alzheimer's disease (AD) plays a vital role in slowing the progression of AD and improving the quality of human life. However, it is still a challenge in the medical field. Herein, an ultrasensitive fluorescent aptasensor was designed for the detection of special phosphorylated tau181 (P-tau181) by coupling with polyvalent aptamers (PAs) structure, hybridization chain reaction (HCR), and the CRISPR-Cas system.

Gender and Age Differences in Corpus Callosum Morphology: High-Altitude Adaptations in Native Tibetan Populations.

Background And Aims: The corpus callosum is recognized as the largest interhemispheric white matter structure, coordinating distinct functions of the brain. High-altitude environments may influence the structure of the corpus callosum. This study aims to evaluate the morphologic characteristics of the corpus callosum in Tibetans residing on the Qinghai-Tibet Plateau while investigating the effects of sex, age, and high-altitude exposure on its morphology.

Novel Device for in Situ and Real-Time Detection of the Acidity of Ambient Aerosols: Laboratory Characterization and Ambient Measurements.

Aerosol acidity, defined as pH, is a critical property that influences the formation, evolution, and health and climate effects of atmospheric aerosol particles. Direct measurement of ambient aerosol pH, however, remains challenging for atmospheric scientists. Here, based on the method of colorimetric analysis on aerosol-loaded pH-indicator papers, we develop a new device that can achieve in situ and real-time measurement of the pH of ambient aerosol droplets at a fixed relative humidity of 90%.

Comparative evaluation of sensititre YeastOne and VITEK2 antifungal susceptibility tests with CLSI broth microdilution method of clinical isolates in Taiwan.

Unlabelled: Commercial antifungal susceptibility tests were available for clinical yeast isolates. However, the updated Sensititre YeastOne (SYO) version YO10C excluded species for susceptibility testing. Uncorrelation of antifungal susceptibility patterns by SYO and therapeutic outcomes had been recently reported.

Development of a Nanobody-Alkaline Phosphatase Fusion Protein for Detection of SARS-CoV-2 Spike Protein in a Fluorescence Enzyme Immunoassay.

The continuous spread and evolution of severe acute respiratory symptom coronavirus 2 (SARS-CoV-2) necessitate the development of convenient and rapid detection methods. In this study, we developed a fluorescence enzyme immunoassay (FEIA) based on a nanobody (Nb)-alkaline phosphatase (ALP) fusion protein for detection of SARS-CoV-2 spike protein. The genetically modified anti-SARS-CoV-2 S-RBD Nb, Nb61, gene was fused with the ALP gene sequences via a flexible linker.

A roller-type triboelectric nanogenerator based on rotational friction between wool and stacked interfaces for omnidirectional wind energy harvesting.

It is urgently desired to develop high-performance wind energy collectors to power numerous microelectronic devices along with the Internet of Things (IoT). A roller-type triboelectric nanogenerator (R-TENG) based on rotational friction between wool and stacked interfaces is proposed and efficiently used for harvesting wind energy. Wool, an electropositive and flexible material, is utilized in the design, effectively reducing abrasion on the contact surface and adjusting the output in response to varying compression levels.

Neddylation drives myofibrillogenesis in the developing heart.

Neddylation is a highly conserved post-translational modification that plays critical roles in various cellular processes through the modulation of cullins and non-cullin substrates. While neddylation is known to be essential for embryonic development, tumor growth, and organogenesis of different tissues, its role in cardiogenesis remains unexplored. Here, we investigated the role of neddylation in early cardiac development by deleting the gene encoding a regulatory subunit of the NEDD8-specific E1 activating enzyme, Nae1, globally and in a heart-specific fashion via Nkx2-5.

Prognostic Value of Serum Interleukin-37 in Patients with Acute Respiratory Distress Syndrome.

Background: Acute respiratory distress syndrome (ARDS) is prominently characterized by uncontrolled inflammation and high mortality. The effect of interleukin-37 (IL-37) on the prognosis of ARDS remains unclear.

Methods: This prospective cohort study detected and analyzed serum IL-37 levels on day 1 (baseline) in 128 patients with ARDS and 40 healthy controls, and on day 7 in patients with ARDS.

Radiation-induced aberrant structural covariance networks in patients with nasopharyngeal carcinoma: a source-based morphometry study.

Background: Radiation-induced brain injury (RBI) is a common complication in patients with nasopharyngeal carcinoma (NPC) who have undergone radiotherapy (RT), which is characterized by significant cognitive and psychological impairments. Although radiation-induced regional structural abnormalities have been well-reported, the effects of RT on the whole brain structural covariance networks are mostly unknown. Here, we performed a source-based morphometry (SBM) study to solve this issue.

Diffusion-weighted imaging as a non-gadolinium alternative for immediate assessing nonperfused area of adenomyosis after magnetic resonance-guided focused ultrasound (MRgFUS) ablation: a potential technique but with slightly overestimate.

Background: It is a technical challenge to monitor ablation outcome during magnetic resonance-guided focused ultrasound (MRgFUS) treatment using non-gadolinium technique. The study aimed to investigate the value of diffusion-weighted imaging (DWI) for immediately assessing nonperfused area of adenomyosis after MRgFUS treatment.

Methods: We retrospectively included patients with adenomyosis who underwent MRgFUS ablation and underwent both DWI (b=800 sec/mm) and contrast-enhanced (CE) magnetic resonance (MR) imaging within 15 minutes after treatment.

Using a two sample Mendelian randomization approach to explore the causal relationship between erectile dysfunction and lung function.

Background: Recently, some observational studies have suggested potential associations between erectile dysfunction (ED) and respiratory function. However, the underlying biological mechanisms and causal relationships between ED and lung function require further investigation. This study aimed to explore the causalities between ED and lung function traits.

Study on the Technical Parameters for Estimating HIV-1 Incidence by Using a Recombinant Antigen-based Capture Enzyme Immunoassay - China.

Introduction: A novel recombinant antigen-based capture enzyme immunoassay (RAg-CEIA) was optimized and used to determine technical parameters for estimating human immunodeficiency virus type 1 (HIV-1) incidence in China.

Methods: We employed orthogonal experimental design to optimize RAg-CEIA by adjusting raw material dilution ratios. The assay was used to measure normalized optical density (ODn) values in 171 longitudinal plasma specimens from 51 HIV-1 seroconverting individuals, plotted against estimated days post-seroconversion.

Diphtheria Toxoid-Derived T-Helper Epitope and α-galactosylceramide Synergistically Enhance the Immunogenicity of Glycopeptide Antigen.

The tumor-associated antigen MUC1 is an attractive target for immunotherapy, however, its weak immunogenicity limits the induction of antitumor immune responses. To overcome this limitation, in this study, MUC1 glycopeptide was covalently linked with a diphtheria toxin-derived T-helper epitope (DT). Subsequently, the resulting DT-MUC1 glycopeptide was physically mixed with natural killer T cell agonist αGalCer to explore their immunomodulatory synergy.

A new species of the jawfish genus from Taiwan, northwestern Pacific Ocean (Perciformes, Opistognathidae).

A new species of jawfish genus is described based on a specimen collected from a beach in the Peng-hu Islands during a cold snap. The new species, , differs from its congeners in having a rigid upper jaw, 10-11 + 1 + 19-22 = 31-33 gill rakers, 55 scale rows in lateral series, 10 + 16 = 26 vertebrae, the terminus of the lateral line at the base of the fourth segmented dorsal-fin ray (15 in total rays), the head, nape, dorsal-fin base above lateral line, throat, chest, and pectoral-fin base naked, dorsal fin with eight blotches along its entire base, body with five horizontal dark stripes, nape with two dark blotches in front of the dorsal-fin origin, and a caudal fin with five narrow, dark bands. A detailed description is provided and compared to its similar congeners.

, a new beardfish from the western Pacific (Teleostei, Polymixiiformes, Polymixiidae).

A new species of beardfish, genus , is described based on three specimens collected in Taiwanese waters and off the Chesterfield Islands of New Caledonia. It can be distinguished from its congeners by the following characters: dorsal-fin rays IV-V, 35-37; gill rakers on outer face of first gill arch 3+1+6=10; scales row between dorsal-fin origin and lateral line vertically 6-8 (S1) and posteriorly 12-14 (S2); pyloric caeca 40; snout rounded, with its surface rough and gelatinous, its tip evidently protrude anterior margin of premaxilla; ctenii on body scales arranged in a wedge-shape, forming three rows; 4 anal-fin spine long, 1.0%-1.

Serum 25-hydroxy vitamin D level is associated with elastography-detected liver fibrosis in patients with type 2 diabetes mellitus in China.

Objective: In this cross-sectional study including patients with type 2 diabetes mellitus (T2DM) we aimed to explore the relationship between serum 25-hydroxy vitamin (25(OH)D) level and liver steatosis and fibrosis in the Chinese population.

Methods: Patients visiting 16 clinical centers with T2DM were recruited. Their liver steatosis and fibrosis status were then assessed using elastography.