Publications by authors named "Xian-Ling Dai"
Background Aims: As a global health threat, NASH has been confirmed to be a chronic progressive liver disease that is strongly associated with obesity. However, no approved drugs or efficient therapeutic strategies are valid, mainly because its complicated pathological processes is underestimated.
Approach Results: We identified the RING-type E3 ubiquitin transferase-tripartite motif-containing protein 31 (TRIM31), a member of the E3 ubiquitin ligases family, as an efficient endogenous inhibitor of transforming growth factor-beta-activated kinase 1 (mitogen-activated protein kinase kinase kinase 7; MAP3K7), and we further confirmed that TRIM31 is an MAP3K7-interacting protein and promotes MAP3K7 degradation by enhancing ubiquitination of K48 linkage in hepatocytes.
Article Synopsis
- Research highlights the link between ambient PM exposure and neurological diseases, focusing on the role of the Rhbdf2 gene in inflammation-related conditions.
- Long-term exposure to particulate matter (PM) led to metabolic disorders in control mice, but Rhbdf2-deficient mice showed improved metabolic parameters.
- The study suggests that Rhbdf2 contributes to hypothalamic injury and neuronal loss, indicating it could be a potential target for mitigating the effects of air pollution on health.