The FSHR G-29A variant is not associated with the ovarian response to exogenous FSH stimulation.

A common genetic variant in the follicle stimulating hormone receptor gene (FSHR) 5'-untranslated region has been previously reported to influence FSHR gene expression. However, studies on the ovarian response to exogenous gonadotropin stimulation are limited. The aim of this study was to evaluate the association of variants at positions -29 of the FSHR gene with the ovarian response to exogenous FSH stimulation in Chinese women.

Sequence variants in FSHR and CYP19A1 genes and the ovarian response to controlled ovarian stimulation.

Objective: To examine whether sequence variants within the FSHR and CYP19A1 genes are related to the ovarian response to controlled ovarian stimulation (COS).

Design: Genetic association study using both single-gene and combined analyses of women with sequence variants undergoing in vitro fertilization treatment.

Setting: Academic research institute hospital.

Roles of mechanical force and CXCR1/CXCR2 in shear-stress-induced endothelial cell migration.

We previously demonstrated that CXCR1 and CXCR2 are novel mechanosensors mediating laminar shear-stress-induced endothelial cell (EC) migration (Zeng et al. in Cytokine 53:42-51, 2011). In the present study, an analytical model was proposed to further analyze the underlying mechanisms, assuming the mechanical force (MF) and mechanosensor-mediated biochemical reactions induce cell migration together.