TP53 loss-of-function causes vulnerability to autophagy inhibition in aggressive prostate cancer.

Objectives: TP53 loss-of-function is commonly found in aggressive prostate cancer. However, a highly-efficient therapy for this tumor subtype is still lacking. In this study, we investigated the relationship between TP53 mutation status and autophagy in prostate cancer and assessed the efficacy of autophagy inhibitors on TP53-deficient tumors.

Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter.

In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-gamma in the liver. Rosiglitazone, PPAR-gamma agonist, activated the GLUT2 mRNA level in the primary cultured hepatocytes and Alexander cells, when these cells were transfected with PPAR-gamma/RXR-alpha. We have localized the peroxisome proliferator response element in the mouse GLUT2 promoter by serial deletion studies and site-directed mutagenesis.

[Identification of six species of Cassia seeds by capillary electrophoresis].

Objective: To identify Cassia seeds of six species by capillary electrophoresis.

Method: The water-soluble extracts of Cassia seeds of six species were analyzed by capillary electrophoresis. The running buffer was 0.