Publications by authors named "Xian-Jing Zhao"
Article Synopsis
- Inhibition of Notch1 signaling enhances the ability of astrocytes to generate new neurons after a stroke.
- A rat stroke model was used to study how blocking Notch1 affects reactive astrocytes, specifically by employing the γ-secretase inhibitor DAPT at various time points post-injury.
- Results indicated that administering DAPT 4 days after the stroke improved neurogenesis and recovery of nerve function, highlighting the significance of timing in promoting brain repair.
Parkinson's disease (PD) is a neurodegenerative disorder that is caused by a loss of dopaminergic (DAergic) neurons in mesencephalic substantia nigra (SN). Human umbilical cord mesenchymal stem cells (hUC-MSCs) are capable of self-renewal and differentiation into multiple cell lineages, including DAergic neurons. Thus, hUC-MSCs could be a promising alternative to compensate for the loss of DAergic neurons in PD.
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