Publications by authors named "Xian-Hui Sun"
Aims: This study aimed to compare the clinical outcomes and safety of endovascular treatment (EVT) in patients with primary versus secondary medium vessel occlusion (MeVO).
Methods: From the endovascular treatment for acute ischemic stroke in the China registry, we collected consecutive patients with MeVO who received EVT. The primary endpoint was a good outcome, defined as a modified Rankin Scale (mRS) 0 to 2 at 90 days.
Article Synopsis
- The study investigates whether using intra-arterial tenecteplase (TNK) during the first attempt at endovascular treatment (EVT) improves outcomes for patients with acute ischemic stroke due to large vessel occlusion (LVO).
- The BRETIS-TNK trial enrolled 26 patients and found that the rate of successful reperfusion was higher in the TNK group compared to a historical control group, especially after adjusting for other factors.
- Additionally, the trial suggests TNK administration is safe, with similar rates of complications, and there's potential for better functional independence at 90 days post-treatment.
Article Synopsis
- The study aimed to create a scoring tool to predict the risk of symptomatic intracranial hemorrhage (sICH) in stroke patients who show contrast enhancement (CE) on brain CT scans after a specific treatment called endovascular thrombectomy (EVT).
- Researchers analyzed data from patients who suffered acute ischemic stroke (AIS) and had CE on their CT scans post-EVT, using multivariable logistic regression and other statistical methods to derive a predictive score.
- Key findings indicated that factors like age over 70, the presence of atrial fibrillation, high serum glucose levels, and specific locations of CE were strong indicators of sICH, and these factors were combined into the CAGA score, which proved to be a reliable
Association between collaterals, cerebral circulation time and outcome after thrombectomy of stroke.
Ann Clin Transl Neurol
February 2023
Article Synopsis
- This study investigates how cerebral circulation time (CCT) and collateral score (CS) relate to functional outcomes in patients with acute ischemic stroke (AIS) after endovascular treatment (EVT).
- Researchers measured CCT and CS in patients with large vessel occlusion and explored the link between these factors using statistical analyses.
- Findings revealed that a higher change in CCT was linked to a lower CS, and the combination of these two factors was a strong predictor of patients' functional outcomes.
Article Synopsis
- Endovascular treatment (EVT) is the preferred method for treating acute ischemic stroke caused by large vessel occlusion (LVO), allowing for analysis of blood contents from the affected areas.
- A study of 45 LVO patients undergoing EVT found notable alterations in blood gas values and electrolytes, particularly K+, Ca2+, and pH levels before and after the procedure, which may help predict patient outcomes.
- Results indicated that specific changes in these blood parameters, especially the proximal/femoral ratios of pH and Na+, correlate with clinical improvements within 72 hours post-treatment, highlighting the potential for these metrics in assessing stroke recovery.
Contrast enhancement (CE) on brain non-contrast computed tomography (NCCT) is common after endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS), but its association with clinical outcomes is not well established. The current study aimed to investigate this relationship. We retrospectively reviewed consecutive patients with acute ischemic stroke who had hyperdensity on NCCT immediately after EVT for anterior circulation large vessel occlusion (LVO) from January 2016 to December 2019.
View Article and Find Full Text PDFBackground Despite successful recanalization, up to half of patients with acute ischemic stroke caused by large-vessel occlusion treated with endovascular treatment (EVT) do not recover to functional independence. We aim to evaluate the role of cerebral circulation time (CCT) as outcome predictor after EVT. Methods and Results We retrospectively enrolled consecutive patients with acute ischemic stroke-large-vessel occlusion undergoing EVT.
View Article and Find Full Text PDFNONCODEV5: a comprehensive annotation database for long non-coding RNAs.
Nucleic Acids Res
January 2018
NONCODE (http://www.bioinfo.org/noncode/) is a systematic database that is dedicated to presenting the most complete collection and annotation of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs).
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