Publications by authors named "Xian-Hui Jv"
Acta Pharmacol Sin
February 2024
Article Synopsis
- Cell senescence plays a significant role in the development of Parkinson's disease (PD), with α-synuclein aggregation and iron deposition being key factors in this process.
- In a mouse model, overexpression of α-syn-A53T led to increased inflammation, cell senescence markers, and mitochondrial dysfunction, but noticeable neuronal loss was only evident after four weeks.
- Iron overload exacerbated oxidative stress and cell senescence triggered by α-syn-A53T, while reducing iron levels showed promise in improving outcomes, suggesting a potential therapeutic avenue for PD.
