Publications by authors named "Xian-Hua Tang"
Article Synopsis
- The study aimed to compare the effectiveness of reduced intensity conditioning (RIC) versus myeloablative conditioning (MAC) in stem cell transplantation for hematologic malignancies, focusing on survival rates and complications.
- After analyzing data from 29 studies with 6235 patients, results showed that RIC had better overall survival at one year but lower disease-free survival rates after two years compared to MAC.
- While RIC also had fewer instances of severe acute graft-versus-host disease and lower treatment-related mortality, it was associated with a higher relapse rate; overall, RIC was found to be equivalent or better than MAC in terms of overall survival but fell short in disease-free survival in the long run.
The aim of the study was to compare the therapeutic efficacy of total body irradiation (TBI)/cyclophosphamide (CY) versus BU/CY as conditioning regimen for leukemia. We electronically searched the Cochrane Central Register of Controlled Trials, Medline, Embase, CIBMTR and critically appraised all relevant articles (1990.01-2009.
View Article and Find Full Text PDFObjective: The aim of this meta-analysis is to compare the HLA disparities and the outcome of UCBT, i.e. the disease-free survival (DFS), engraftment, graft-versus-host disease, (GVHD), and transplantation related mortality (TRM).
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- * A meta-analysis of 9 clinical trials, involving 3039 patients, was conducted to evaluate factors like stem cell engraftment, complications, and disease-free survival rates between the two treatment groups.
- * Findings show no significant difference in engraftment failure and mortality, but higher complications were observed in both groups; TBI/CY had a lower relapse rate in acute myeloid leukemia (AML) but higher in chronic myeloid leukemia
UCB has been used as an alternative source of HSC. Both unrelated donor BM and UCB are available as potential options for transplantation. However, there have been limited comparisons of the outcomes of unrelated donor UCBT vs.
View Article and Find Full Text PDFThe development of modern molecular biological techniques makes it possible to study minimum DNA from ancient materials. During past decade,a lot of significant achievements on ancient DNA research have been made in many fields especially in molecular evolutionary biology. The nature of degradation and contamination of ancient DNA from ancient biological materials pose a dominating problem in ancient DNA research.
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