Lectin-induced renal local complement activation is involved in tubular interstitial injury in diabetic nephropathy.

Background: Complement has been suggested to be involved in diabetic nephropathy (DN), but the exact significance and underlying mechanisms remain unclear. Data about renal local complement activation in DN patients is scarce. The purpose of the study was to clarify the significance and mechanism of renal local complement activation in DN.

Longikaurin E induces apoptosis of pancreatic cancer cells via modulation of the p38 and PI3K/AKT pathways by ROS.

Pancreatic cancer is a devastating disease with a poor prognosis. It ranks as the fourth or fifth most common cancer in men and women and has the lowest 5-year survival rate. Therefore, there is an urgent need to develop novel therapeutic agents for pancreatic cancer.

[Nephrotic syndrome complicated with intracranial venous thrombosis treated with urokinase: report of 5 cases].

Objective: To explore the effect of urokinase and low molecular weight heparin in children with nephrotic syndrome complicated with intracranial venous thrombosis.

Methods: Urokinase and low molecular weight heparin were administered to the 5 patients intravenously. The initial dose of urokinase was 2000 - 4000 U/(kg.

[Clinical and pathological study of 47 cases with Alport syndrome].

Objective: To analyze the clinical and pathological features of children with Alport syndrome (AS).

Methods: A series of 47 patients with AS from unrelated families hospitalized from Jan. 1990 to Jan.