Publications by authors named "Xian-Bo Wu"
Background And Objectives: Mobility limitations have been linked to cognition. However, little is known about the relationship between mobility decline and cognitive decline. This study investigated the effect of mobility limitations and decline on cognitive decline in a population-based cohort of older adults.
View Article and Find Full Text PDFArticle Synopsis
- Frailty significantly increases the risk of developing chronic liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), cirrhosis, and liver cancer, as well as liver-related mortality.
- A comprehensive study involving over 339,000 participants found that those classified as prefrail or frail had substantially higher risks for these conditions compared to non-frail individuals, based on a follow-up period averaging 11.6 years.
- The findings suggest a need for public health initiatives aimed at reducing the risk of liver diseases in frail populations, emphasizing the importance of addressing frailty in chronic disease management.
Background: It's unclear if excess visceral adipose tissue (VAT) mass in individuals with prediabetes can be countered by adherence to a Mediterranean lifestyle (MEDLIFE). We aimed to examine VAT mass, MEDLIFE adherence, and their impact on type 2 diabetes (T2D) and diabetic microvascular complications (DMC) in individuals with prediabetes.
Methods: 11,267 individuals with prediabetes from the UK Biobank cohort were included.
Background: Healthier lifestyle decreased the risk of mental disorders (MDs) such as depression and anxiety. However, research on the effects of a comprehensive healthy lifestyle on their progression is lacking.
Methods: 385,704 individuals without baseline MDs from the UK Biobank cohort were included.
Background: To assess the roles of diabetic microvascular disease and modifiable risk factors and their combination in the development of arrhythmias.
Methods: We included participants with type 2 diabetes (T2D) who were free of arrhythmias during recruitment in the UK Biobank study. The associations of microvascular disease states (defined by the presence of retinopathy, peripheral neuropathy or chronic kidney disease), four modifiable arrhythmic risk factors (body mass index, smoking, systolic blood pressure and glycosylated haemoglobin) and their joint associations with incident arrhythmias were examined.
Objective: To examine the associations between microvascular disease (MVD) and risk of stroke, dementia, and their major subtypes among individuals with type 2 diabetes mellitus (T2DM).
Methods: We included 26,173 participants with T2DM from the UK Biobank who had no known stroke or dementia at baseline. MVD burden was reflected by the presence of retinopathy, peripheral neuropathy, and chronic kidney disease.
Context: The interplay between cardiovascular health metrics (CVHMs) and microvascular disease (MVD) in relation to the risk of incident coronary heart disease (CHD) among individuals with type 2 diabetes mellitus (T2DM) remains to be evaluated.
Objective: To investigate the role of MVD and CVHMs in the development of CHD among T2DM.
Design: We included 19 664 participants with T2DM from the UK Biobank who had CVHM data and were free of CHD during recruitment.
Article Synopsis
- The study investigates how changes in waist circumference (WC), waist-to-height ratio (WHtR), and weight-adjusted-waist index (WWI) relate to the risk of multimorbidity in older Chinese adults, using data from the Chinese Longitudinal Healthy Longevity Survey.
- A total of 2900 participants aged 65 and above were tracked over several years, revealing that increases in WC and WHtR corresponded with a higher risk of multiple chronic diseases, whereas a decrease in WWI was linked to a lower risk.
- The results underscore significant associations between changes in body measurements and the likelihood of developing multimorbidity, with modest increases in these metrics correlating to increased health risks.
Aims: To assess the impact of long-term visit-to-visit variability in HbA on microvascular outcomes in type 2 diabetes mellitus (T2DM), and its influence on the effects of intensive glycemic control.
Methods: Included were participants with T2DM enrolled in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) who had at least three measurements of HbA prior to new-onset microvascular outcomes, namely nephropathy, retinopathy and neuropathy. Variability in HbA was defined as the coefficient of variation (CV) across HbA measurements obtained from enrollment to the transition from intensive to standard glycemic therapy.
Background: The human gut microbiota (GM) has been recognized as a significant factor in the development of insomnia, primarily through inflammatory pathways, making it a promising target for therapeutic interventions. Considering the principles of primary prediction, targeted prevention, and personalized treatment medicine (PPPM), identifying specific gut microbiota associated with insomnia and exploring the underlying mechanisms comprehensively are crucial steps towards achieving primary prediction, targeted prevention, and personalized treatment of insomnia.
Working Hypothesis And Methodology: We hypothesized that alterations in the composition of specific GM could induce insomnia through an inflammatory response, which postulates the existence of a GM-inflammation-insomnia pathway.
Ethnopharmacological Relevance: Guomin decoction (GMD) is a traditional Chinese medicine commonly used in clinical practice. It has traditionally been used to treat all allergic diseases. Currently, Jiawei Guomin Decoction (JWGMD) is used to treat sensitive skin after initial therapy.
View Article and Find Full Text PDFShift work and risk of incident gastroesophageal reflux disease: the association and mediation.
Front Public Health
September 2023
Introduction: Shift work has become an increasingly common work mode globally. This study aimed to investigate the association between shift work and the risk of incident gastroesophageal reflux disease (GORD), an upward gastrointestinal disorder disease worldwide, and to explore the mediating factors.
Method: A total of 262,722 participants from the UK Biobank free of GORD and related gastrointestinal diseases were included to investigate the association and potential mediators between shift work and incident GORD.
Background To evaluate the sex-specific associations of total and regional fat/muscle mass ratio (FMR) with cardiovascular disease (CVD) incidence and mortality, and to explore the underlying mechanisms driven by cardiometabolites and inflammatory cells. We compared the predictive value of FMRs to body mass index. Methods and Results This population-based, prospective cohort study included 468 885 UK Biobank participants free of CVD at baseline.
View Article and Find Full Text PDFObjective: To evaluate associations of Life's Essential 8 (LE8) score, the recently updated metric for promoting cardiovascular health (CVH), with the risk of incident dementia and its subtypes, cognition, and neuroimaging outcomes and to determine whether these associations differ among apolipoprotein E (APOE)-ε4 genotypes.
Design: Prospective cohort study.
Setting And Participants: A total of 316,669 participants [mean (SD) age, 56.
Background: Arterial stiffness contributes to additional cardiovascular risks in diabetic patients by triggering the loss of vascular and myocardial compliance and promoting endothelial dysfunction. Thus, prevention of arterial stiffness is a public health priority, and the identification of potential biomarkers may provide benefits for early prevention. This study investigates the relationships between serum laboratory tests and pulse wave velocity (PWV) tests.
View Article and Find Full Text PDFBackground: Research on the association of physical activity and sedentary time with dementia is accumulating, though elusive, and the interaction effects of the two remain unclear. We analysed the joint associations of accelerometer-measured physical activity and sedentary time with risk of incident dementia (all-cause dementia, Alzheimer's disease and vascular dementia).
Methods: A total of 90,320 individuals from the UK Biobank were included.
Background: Existing evidence concerning the relationship between daytime napping and type 2 diabetes (T2D) is inconsistent, and whether the effects of napping differ by body fat percentage (BFP) and C-reactive protein (CRP) is unclear. We aimed to investigate the association between daytime napping frequency and T2D risk and whether such an association was modified by BFP and CRP.
Methods: We included 435 342 participants free of diabetes from the UK Biobank.
To examine the association between visit-to-visit blood pressure variability (BPV) and incident diabetes mellitus (DM) risk in a Chinese population. Data comes from China Health and Nutrition Survey ( = 15,084). BPV was estimated as the average real variability (ARV) using at least three BP measurements from the year preceding the event and was divided into quartiles.
View Article and Find Full Text PDFThe Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking.
J Gerontol A Biol Sci Med Sci
December 2023
Background: The influence of overall air pollution on dementia risk and the potential effect modification by other risk factors remain to be clarified.
Methods: We included 459 844 UK residents who were free of dementia and had data on the exposure to particulate matter (PM)2.5, PM2.
Objective: To examine the association between microvascular disease (MVD) and risk of heart failure (HF) among individuals with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM).
Research Design And Methods: We included 1,713 and 28,624 participants with T1DM and T2DM, respectively, from the UK Biobank who were free of HF during enrollment. MVD burden reflected by the presence of retinopathy, peripheral neuropathy, and chronic kidney disease (CKD) at baseline was prospectively evaluated for the association with incidence of HF.
Background: Epidemiological evidence regarding the associations between long-term exposure to air pollution and risk of incident inflammatory bowel disease (IBD) is scant.
Objectives: We examined the associations of various specific air pollutants with the risk of incident ulcerative colitis and Crohn's disease, two subtypes of IBD, among middle and old aged adults in the UK. We also explored potential susceptible subgroups.
Background: Greater lipid variability may cause adverse health events among diabetic patients. We aimed to examine the effect of lipid variability on the risk of diabetic microvascular outcomes among type 2 diabetes mellitus patients.
Methods: We assessed the association between visit-to-visit variability (measured by variability independent of mean) in high-density lipoprotein (HDL) cholesterol, low-density lipoprotein-cholesterol (LDL), triglyceride, and remnant cholesterol (RC) measurements among participants involved in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study and the risk of incident microvascular outcomes, including nephropathy, neuropathy, and retinopathy.