Publications by authors named "Xian-Bin Ma"
Article Synopsis
- Glutathione-responsive nanogels (CDNPs) were created using a crosslinker and combined with the BRAF inhibitor dabrafenib and the COX2 inhibitor celecoxib.
- These nanogels effectively trigger pyroptosis in tumor cells, boosting the body's antitumor immune response.
- When used alongside the αPD-1 antibody, CDNPs significantly reduced tumor growth and extended survival in a melanoma mouse model.
Pyroptosis is demonstrated to trigger antitumor immunity and represents a promising new strategy to potentiate cancer immunotherapy. The number of potent pyroptosis inducers, however, is limited and without tumor-targeting capability, which inevitably causes damage in normal tissues. Herein, a small molecular prodrug of paclitaxel-oxaliplatin is rationally synthesized, which can be covalently self-assembled with diselenide-containing cross-linking (Dse11), producing a diselenide nanoprodrug (DSe@POC) to induce pyroptosis for the first time.
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