A B7H3-targeting antibody-drug conjugate in advanced solid tumors: a phase 1/1b trial.

Antibody-drug conjugates (ADCs) have emerged as a transformative modality in the treatment of solid tumors. YL201, a novel B7H3-targeting ADC, leverages a tumor microenvironment activable linker-payload platform, coupled with a novel topoisomerase 1 inhibitor via a protease-cleavable linker. Here we report the findings from a large-scale, global, multicenter, phase 1 trial evaluating the safety, pharmacokinetics and preliminary efficacy of YL201 in patients with advanced solid tumors refractory to standard therapies.

Single-cell RNA sequencing revealed changes in the tumor microenvironment induced by radiotherapy for cervical cancer and the molecular mechanism of mast cells in immunosuppression.

Radiotherapy (RT) is an important treatment for cervical cancer (CC), effectively controlling tumor growth and improving survival rates. However, radiotherapy-induced cell heterogeneity and its underlying mechanisms remain unclear, which may potentially impact treatment efficacy. This study aims to investigate tumor microenvironment changes following radiotherapy for CC, hoping to provide evidence to improve the therapeutic effects of radiotherapy.

Nicotinamide mononucleotide supplementation ameliorates testicular damage induced by ischemia-reperfusion through reshaping macrophage and neutrophil inflammatory properties.

Background: Ischemia-reperfusion (I/R) injury is the main pathophysiology of testicular torsion-detorsion (T/D). However, there is no safe and effective treatment for testicular I/R injury.

Methods: The levels of NAD related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).

Skin-Inspired and Self-Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy.

Diabetic wounds are refractory and recurrent diseases that necessitate the development of multifunctional dressings. Inspired by the structure and function of the skin, we herein delicately design a novel swollen hydrophobic hydrogel (QL@MAB) composed of hydrophobic methyl acrylate (MA) and (3-acrylamidophenyl)boronic acid (AAPBA) network and co-loaded with antioxidant quercetin (Q) and antibiotic levofloxacin (L) for efficient diabetic wound therapy. The hydrophobic MA segments undergo phase separation to form a dense "epidermis", ensuring prolonged drug diffusion, long-term water retention, and high water content.

Clinical Manifestations of Ocular Toxoplasmosis in Hubei, China: Case Series.

Objective: The clinical features, disease course and visual outcomes of toxoplasmosis are less commonly reported in China than in other countries. To reduce misdiagnosis and improve visual function, the clinical characteristics, management and visual outcomes of 13 cases of ocular toxoplasmosis (OT) were described.

Methods: This retrospective study included 14 eyes of 13 patients who were diagnosed with OT in Hubei, China.

The transcription factor ClWRKY61 interacts with ClLEA55 to enhance salt tolerance in watermelon.

High salinity can severely inhibit the growth and development of watermelon ( L.). WRKY proteins are believed to mediate the adaptation of plants to abiotic stresses.

Ameboid Microglia as a Scavenger Role in Phagocytosis of Photoreceptor Outer Segment in an Experimental Retinal Detachment Model.

Purpose: Photoreceptor (PR) death is the ultimate cause of irreversible vision loss in retinal detachment (RD). Previous studies have shown that microglia may have a dual role in RD. Nevertheless, the potential protective effects of microglia on PR are largely unknown.

A Keap1-recruiting BRD4 degrader offers a single-molecular polypharmacology approach for the treatment of metabolic dysfunction-associated steatohepatitis.

The pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH) involves multiple pathophysiological processes, including abnormal lipid metabolism, insulin resistance, oxidative stress, endoplasmic reticulum stress, inflammatory response, and fibrosis. These factors interact to form a complex network and the development of synergistic and pleiotropic drug modalities targeting multiple pathogenesis of MASH may have a better therapeutic effect. Herein, the bifunctional proteolytic targeting chimeras (PROTAC) technology was utilized for developing pleiotropic drugs for MASH treatment.

Twisted optical needle array sourced by a circular hyperbolic umbilic beam.

In this Letter, we propose an ultralong twisted optical needle array, derived from a circular hyperbolic umbilic beam (CHUB) array. When propagating within a parabolic potential, the CHUBs periodically focus on optical needles. By extending the Heisenberg equation from quantum mechanics to optics, we theoretically demonstrate that introducing a linear chirp phase and offset modulation causes the optical needles to propagate along spiral trajectories.

Collagen Scaffold Augments the Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells in a Rat Model of Intrauterine Adhesion.

Intrauterine adhesion (IUA) caused by endometrial injury is the most common cause of female uterine infertility. Current treatments offer limited clinical benefits. In this study, we investigated the role of human umbilical cord mesenchymal stem cells (hUCMSCs) loaded collagen scaffold in the regeneration of injured human endometrium in an IUA rat model.

A self-amplifying NO-HS loop mediates melatonin-induced CBF-responsive pathway and cold tolerance in watermelon.

Melatonin is a pivotal bioactive molecule that enhances plant cold stress tolerance, but the precise mechanisms remain enigmatic. Here, we have discovered that overexpressing melatonin biosynthetic gene ClCOMT1 or applying exogenous melatonin activates the C-repeat binding factor (CBF)-responsive pathway and enhances watermelon cold tolerance. This enhancement is accompanied by elevated levels of nitric oxide (NO) and hydrogen sulfide (HS), along with upregulation of nitrate reductase 1 (ClNR1) and L-cysteine desulfhydrase (ClLCD) genes involved in NO and HS generation respectively.

TDP-43/ALKBH5-mediated mA modification of CDC25A mRNA promotes glioblastoma growth by facilitating G1/S cell cycle transition.

Glioblastoma (GBM) exhibits significant intratumor heterogeneity (ITH), indicating the presence of tumor cells with diverse growth rates. Here, we aimed to identify fast-growing cells in GBM and elucidate the underlying mechanisms. Precisely targeting these cells could offer an improved treatment option.

Retraction note to: Shugan Jieyu capsule effects on peripheral blood micro-124, micro-132, and brain-derived neurotrophic factor in patients with mild to moderate depression.

[This retracts the article on p. 1354 in vol. 14, PMID: 39319232.

Reducing exciton binding energy of antimony-based perovskites by improving the phase purity for efficient solar cells.

Antimony-based halide perovskites have attracted significant attention owing to their unique optoelectronic properties and low toxicity. However, the distinct defect physics and high exciton binding energy of antimony-based perovskites compared with their lead-based analogues significantly hinder the photovoltaic performance of antimony-based perovskite solar cells (PSCs). In this work, a feasible strategy by regulating the precursor composition is introduced to mitigate the defects and impurity phases of CsSbClI films.

"Frozen" Ionogels with High and Tunable Toughness for Soft Electronics.

As a promising material, ionogels have garnered increasing interest in various applications including flexible electronics and energy storage. However, most existing ionogels suffer from poor mechanical properties. Herein, an effective and universal strategy is reported to toughen ionogels by freezing the polymer network via network design.

Distinguishing features of microvascular abnormalities in high myopia retinoschisis via multimodal imaging.

Purpose: To report the differences between microvascular abnormalities (MVAs) and retinal vasculitis in patients with high myopia (HM) and retinoschisis and discuss the efficacy of treatments, including corticosteroids, and posterior vitreous detachment (PVD).

Methods: We enrolled seven patients with HM retinoschisis in the Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Multimodal imaging features of MVAs were examined using ultrawide scanning laser ophthalmoscopy, swept-source optical coherence tomography (SS-OCT), SS-OCT angiography (SS-OCTA), and fundus fluorescein angiography (FFA).

Polymerization of beneficial plant height QTLs to develop superior lines which can achieving hybrid performance levels.

Unlabelled: Heterosis, a key technology in modern commercial maize breeding, is limited by the narrow genetic base which hinders breeders from developing superior hybrid varieties. By integrating big data and functional genomics technologies, it becomes possible to create new super maize inbred lines that resemble hybrid varieties through the aggregation of multiple QTL parental advantage loci. In this study, we utilized a combination of resequencing and field selfing selection methods to develop three pyramiding QTL lines (PQLs) (PQL4, 6, and 7), each containing 15, 12, and 12 QTL loci respectively.

Leaf Vein-Inspired Programmable Superstructure Liquid Metal Photothermal Actuator for Soft Robots.

Asymmetric-expansion photothermal actuators have attracted the attention of researchers owing to their simple structure, superior stability, rapid response, and precise controllability. However, their response speed, deformation capacity, and load-carrying capacity are mutually constrained by their thickness. Inspired by the veins and pulp in plant leaves, this study uses laser etching to apply a superstructure of ordered grooves to liquid metal (LM) photothermal actuators.

Clinical efficacy of Tuina therapy combined with traditional Chinese exercises in the treatment of symptomatic lumbar disc herniation: a multicentre randomised controlled trial protocol.

Background: Low back pain and lower extremity sensory and functional abnormalities are common symptoms of lumbar disc herniation (LDH), which can easily cause walking dysfunction and significantly impair the quality of life of patients. Tuina and traditional Chinese exercises (TCEs) are effective in relieving pain and restoring dysfunction, and both are often used in China as a combination of passive therapy and active exercise to ease symptoms in patients with LDH. However, the majority of current clinical trials on the treatment of LDH with Tuina or TCEs are single-centre clinical studies, and the quality of these studies is generally low.

Linoleic acid metabolism is implicated in the anti-obesity effects of actein in C57BL/6 mice.

Natural products are known to be a rich source of potential compounds for metabolic diseases. In this study, we aim to identify the lead compounds with anti-adipogenic and anti-obesity effects in Cimicifuga foetida L. (CF).

Metagenomic insights into the assembly, function, and key taxa of bacterial community in full-scale pesticide wastewater treatment processes.

Pesticide wastewater emerges as a typical refractory wastewater, characterized by complex composition and high toxicity, posing significant treatment challenges. Bacterial communities are responsible for biological treatment of refractory wastewater in full-scale pesticide wastewater treatment plants (PWWTPs), providing important implications for optimizing system performance and improving management strategies. However, the knowledge of their composition, diversity, function, assembly patterns, and biological interactions remains limited.

Mitigating effects of Jiawei Chaihu Shugan decoction on necroptosis and inflammation of hippocampal neurons in epileptic mice.

Jiawei Chaihu Shugan decoction (JWCHSGD) is a traditional Chinese medicine well-known for its beneficial effects in treating epilepsy (Xianzheng in ancient Chinese), but the molecular mechanism of its action remains unclear. To investigate the molecular mechanism of JWCHSGD's prevention of epilepsy-mediated neuron from necroptosis and inflammation via the circRNA-Csnk1g3/Csnk1g3-85aa/ CK1γ3/TNF-α signal pathway. In vitro, murine neuronal HT22 cells were treated in six groups: control, model, carbamazepine, and three JWCHSGD doses (high, medium, low).

Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy.

Background: Glioma, particularly glioblastoma (GBM), is a highly aggressive tumor with limited responsiveness to immunotherapy. PANoptosis, a form of programmed cell death merging pyroptosis, apoptosis, and necroptosis, plays an important role in reshaping the tumor microenvironment (TME) and enhancing immunotherapy effectiveness. This study investigates PANoptosis dynamics in glioma and explores the therapeutic potential of its activation, particularly through natural compounds such as cinobufagin.

Additions to the saprobic fungi (Ascomycota) associated with macadamia trees from the Greater Mekong Subregion.

Macadamia trees, the most economically important Proteaceae perennial crop, are globally renowned for their edible nuts. During our surveys of microfungi associated with macadamia in China and Thailand, we isolated three saprobic fungi from dead macadamia branches. Our multigene phylogenetic analyses (ITS, LSU, SSU, 1-α, 2, and loci), genealogical concordance phylogenetic species recognition (GCPSR) with a pairwise homoplasy index (PHI) test, and morphological characteristics led to the discovery of two new species, and , and one new record, .