Human salivary histatin 1 regulating IP3R1/GRP75/VDAC1 mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) inhibits cell senescence for diabetic wound repair.

Rationale: Difficulty in skin wound healing is a concern for diabetic patients across the world. Impaired mitochondrial dysfunction and aging-related vascular dysfunction in human umbilical vein endothelial cells (HUVECs) caused by oxidative stress are major impediments to diabetic wound healing. However, research on skin repair at the mechanistic level by improving mitochondrial function and inhibiting oxidative stress-induced HUVEC senescence remains lacking.

Bus arrival and departure time updates in the Greater Sydney Area.

Public Transport Authorities generate large quantities of data as part of their daily operations, including vehicle positions, arrival times, and dynamic routing options. This information is essential feedback into the system for planning routes and timetables, modelling passenger demand growth and evaluating operational performance. The General Transit Feed Specification (GTFS) is a data format that allows public transport data to be consumed by a wide variety of software applications.

Identification of a novel protein Hq023 of the hard tick Haemaphysalis qinghaiensis and preliminary evaluation of its analgesic effect in mice model.

Tick saliva contains a range of critical biological molecules which could inhibit host defenses and guarantee their food supply. Hq023, a novel cDNA sequence, was cloned from a cDNA library constructed from salivary glands of partially-engorged Haemaphysalis qinghaiensis. Hq023 has an open reading frame (ORF) of 408 bp coding a protein containing 135 amino acid residues with a molecular mass of 15 kDa.

The YY1-CPT1C signaling axis modulates the proliferation and metabolism of pancreatic tumor cells under hypoxia.

Carnitine palmitoyltransferase 1C (CPT1C) is an enzyme that regulates tumor cell proliferation and metabolism by modulating mitochondrial function and lipid metabolism. Hypoxia, commonly observed in solid tumors, promotes the proliferation and progression of pancreatic cancer by regulating the metabolic reprogramming of tumor cells. So far, the metabolic regulation of hypoxic tumor cells by CPT1C and the upstream mechanisms of CPT1C remain poorly understood.

Ultrasensitive stretchable bimodal sensor based on novel elastomer and ionic liquid for temperature and humidity detection.

In this work, we present a novel stretchable bimodal sensor that can simultaneously detect temperature and humidity changes based on poly-hydroxyethyl acrylate (PHEA) elastomer infused with 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIM-BF4) ionic liquid. The sensor exhibits high transparency, stability, and biocompatibility, as well as excellent mechanical and sensing properties. The sensor can achieve a maximum strain of 761%, a sensitivity of 4.

NIR-Mediated CuO/Au Nanomotors for Synergistically Treating Hepatoma Carcinoma Cells.

We presented a NIR-driven Janus CuO/Au nanomotor. The nanomotor has a truncated octahedral structure. By asymmetric Au evaporation, the light response range of CuO nanomotor is extended to near-infrared range, and the speed of CuO/Au nanomotors under NIR is significantly increased.

Meta-Analysis of the Efficacy and Safety Evaluation of Vandetanib in the Treatment of Medullary Thyroid Cancer.

The aim of the work was to systematically evaluate the efficacy and safety of Vandetanib in the treatment of advanced medullary thyroid carcinoma (MTC). MeSH entries to search for randomized controlled trials and clinical research literature on the application of Vandetanib in the treatment of medullary thyroid cancer from PubMed, Chinese national knowledge infrastructure (CNKI), and Web of Science databases since their establishment until March 2023 were used. In terms of efficacy, the analysis results showed that Vandetanib had a significantly higher objective response rate compared to the control group using placebo (OR=2.

Direct Performance of Triple-Stage Tandem Mass Spectrometry Analysis Using Dual-Direction Dipolar Excitation in a Digital Linear Ion Trap.

The ion trap mass spectrometer offers a unique advantage over other mass spectrometers by enabling multistage tandem mass spectrometry analysis with a single mass analyzer. It is employed to generate fragment ions through collision-induced dissociation (CID) usually by applying alternating current (AC) signals to a pair of electrodes for dipole excitation. The process of achieving double-stage tandem mass spectrometry analysis (MS/MS) in the mass spectrometer involves successive stages of injection, cooling, isolation, excitation, and scanning.

Revealing of long-range soliton interaction induced time and phase dynamics in a mode-locked fiber laser.

By means of the dispersive temporal interferometry technique, we carried out a real-time observation of the time separation and relative phase evolutions of two pulses toward harmonic mode-locking. During the separation stage of the buildup process, the time separation increases, while the relative phase decreases synchronously, and the largest change rates are 0.247 fs/r and -0.

Multifunctional Novel Nanoplatform for Effective Synergistic Chemo-Photodynamic Therapy of Breast Cancer by Enhancing DNA Damage and Disruptions of Its Reparation.

Photodynamic therapy (PDT) is an effective noninvasive therapeutic strategy that has been widely used for anti-tumor therapy by the generation of excessive highly cytotoxic ROS. However, the poor water solubility of the photosensitizer, reactive oxygen species (ROS) depleting by high concentrations of glutathione (GSH) in the tumor microenvironment and the activation of DNA repair pathways to combat the oxidative damage, will significantly limit the therapeutic effect of PDT. Herein, we developed a photosensitizer prodrug (CSP) by conjugating the photosensitizer pyropheophorbide a (PPa) and the DNA-damaging agent Chlorambucil (Cb) with a GSH-responsive disulfide linkage and demonstrated a multifunctional co-delivery nanoplatform ( nanoparticles (NPs)) together with DSPE-PEG and PARP inhibitor Olaparib (Ola).

Non-noble-metal TiC-nanoparticle-promoted charge separation and photocatalytic degradation performance on BiO microrods: degradation pathway and mechanism investigation.

In the present work, a promising binary TiC/BiO photocatalyst was obtained a simple hydrothermal route. In the photodegradation experiment of acid orange 7 (AO7) and tetracycline (TC) irradiated by simulated sunlight, the attachment of TiC nanoparticles on the BiO microrods leads to an obvious improvement in the photocatalytic removal properties of the BiO microrods. The optimal removal efficiency of AO7 was achieved by the 7.

Real-time revealing of Cherenkov radiation evolution in optical fibers.

The generation of Cherenkov radiation (CR) is determined by the phase-matching condition, but the experimental observation on the phase change of its transient process is still incomplete. In this paper, we use the dispersive temporal interferometer (DTI) technique to real-time reveal the buildup and evolution of CR. Experiments show that when the pump power varies, the phase-matching conditions also change, which is mainly affected by the nonlinear phase shift caused by the Kerr effect.

Efficacy of Exenatide Administered Twice Daily in Body Mass Index Reduction in Patients with Type 2 Diabetes Mellitus.

Background: Exenatide is a glucagon-like peptide-1 receptor agonist that can reduce body weight. This study aimed to determine the efficacy of exenatide on body mass index (BMI) reduction in patients with type 2 diabetes mellitus (T2DM) with differing baseline body weight, blood glucose, and atherosclerotic status and to determine if there is a correlation between BMI reduction and cardiometabolic indices in these patients.

Methods: This retrospective cohort study used data from our randomized controlled trial.

Human Embryonic Stem-Cell-Derived Exosomes Repress NLRP3 Inflammasome to Alleviate Pyroptosis in Nucleus Pulposus Cells by Transmitting miR-302c.

Recent studies have shown that the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is extensively activated in the process of intervertebral disc degeneration (IVDD), leading to the pyroptosis of nucleus pulposus cells (NPCs) and the exacerbation of the pathological development of the intervertebral disc (IVD). Exosomes derived from embryonic stem cells (hESCs-exo) have shown great therapeutic potential in degenerative diseases. We hypothesized that hESCs-exo could alleviate IVDD by downregulating NLRP3.

Effect of composted pig manure, biochar, and their combination on antibiotic resistome dissipation in swine wastewater-treated soil.

The prevalence of antibiotic resistance genes (ARGs), owing to irrigation using untreated swine wastewater, in vegetable-cultivated soils around swine farms poses severe threats to human health. Furthermore, at the field scale, the remediation of such soils is still challenging. Therefore, here, we performed field-scale experiments involving the cultivation of Brassica pekinensis in a swine wastewater-treated soil amended with composted pig manure, biochar, or their combination.

Carrier-free nanomedicines self-assembled from palbociclib dimers and Ce6 for enhanced combined chemo-photodynamic therapy of breast cancer.

Palbociclib is the world's first CDK4/6 kinase inhibitor to be marketed. However, it is not effective in the treatment of triple negative breast cancer (TNBC) due to the loss of retinoblastoma protein expression. Thus, combinatorial chemotherapy is indispensable for TNBC treatment.

The Effect of Thunder-Fire Moxibustion on Lumbar Disc Herniation: Study Protocol for a Randomized Controlled Trial.

Background: Lumbar disc herniation (LDH) is a common disease seen in orthopedics; it is caused by nucleus pulposus herniation. Its clinical manifestations are low back pain, radiating pain of the lower limbs, and cauda equina symptoms that seriously affect patients' quality of life. At present, oral analgesics are commonly used in the treatment of LDH; but they can produce gastrointestinal reactions and other side effects.

Comparing the effects of twice-daily exenatide and insulin on renal function in patients with type 2 diabetes mellitus: secondary analysis of a randomized controlled trial.

This is a secondary analysis of a randomized controlled trial (RCT) on the effects of the glucagon-like peptide-1 receptor agonists exenatide and insulin aspartate 30 injection on carotid intima-media thickness. Here, we report the renal outcomes of the intervention in patients with type 2 diabetes mellitus (T2DM). Data from the RCT study was used to evaluate the effect of exenatide or insulin given for 52 weeks on estimated glomerular filtration rate (eGFR) in patients with T2DM.

Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations.

Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in the treatment of burn wounds (BWs). Despite the variety of conventional therapies available, morbidities associated with BWs have not subsided. Therefore, aim of the present study was to design an advanced nanotechnology-composited therapy for effectual management of BWs.

Template-free synthesis of BiOCO hierarchical nanotubes self-assembled from ordered nanoplates for promising photocatalytic applications.

In this study, we have adopted a one-step hydrothermal route to synthesize an interesting type of BiOCO hierarchical nanotubes self-assembled from ordered nanosheets. The effects of reaction time on the morphological and structural evolution, light absorption properties, photoelectrochemical performance, and photocatalytic performance of the prepared hierarchical nanotubes were investigated. Among the products synthesized at different reaction times, the 3-hour-derived BiOCO hierarchical nanotubes were identified to possess the highest photocatalytic performance.

Real-time observation of phase transition of bifurcation evolution in mode-locked lasers.

By using the dispersive temporal holography technology, we observe the real-time dynamics of period-doubling bifurcation evolution in an ultrafast fiber laser. The pulse properties including the phase, polarization state, chirp, pulse width, and pulse energy are fully bifurcated, which embody the bifurcation induced "phase transition." There are two types of bifurcation in the laser buildup: one to many bifurcation towards the chaos and the multiple bifurcated pulses back to the stationary state along the reversed trajectory.

Healing outcomes and predictors among patients with venous leg ulcers treated with compression therapy.

Objective: This study aimed to compare the healing outcomes between three types of compression therapy-two-layer bandage (2LB), four-layer bandage (4LB), and compression stockings, and to identify the predictors of venous leg ulcer (VLU) healing.

Method: A retrospective review of the medical records of patients diagnosed with VLU between 2011 and 2016 in Singapore was conducted. Univariate and multivariate analyses were done between healed and unhealed VLU patients at three and six months, based on potential factors, ranging from demographic profile to comorbidities and treatment-related variables.